Volume 62, Issue 11 pp. 2011-2014

Brief Report

Ovary preservation in the treatment of childhood Meigs syndrome

Corresponding Author

Michael A. Fremed BA

Albert Einstein College of Medicine, Bronx, New York

Correspondence to: Michael A. Fremed, Ullman 813, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. E-mail: [email protected]

Search for more papers by this author

Terry L. Levin MD,

Terry L. Levin MD

Department of Radiology, Division of Pediatric Radiology, Montefiore Medical Center, Bronx, New York

Search for more papers by this author

Katherine Y. Sun MD, PhD,

Katherine Y. Sun MD, PhD

Department of Pathology, Montefiore Medical Center, Bronx, New York

Search for more papers by this author

Daniel A. Weiser MD,

Daniel A. Weiser MD

Departments of Pediatrics and Genetics, Albert Einstein College of Medicine, Bronx, New York

Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Bronx, New York

Search for more papers by this author

Michael A. Fremed BA,

Corresponding Author

Michael A. Fremed BA

Albert Einstein College of Medicine, Bronx, New York

Correspondence to: Michael A. Fremed, Ullman 813, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. E-mail: [email protected]

Search for more papers by this author

Terry L. Levin MD,

Terry L. Levin MD

Department of Radiology, Division of Pediatric Radiology, Montefiore Medical Center, Bronx, New York

Search for more papers by this author

Katherine Y. Sun MD, PhD,

Katherine Y. Sun MD, PhD

Department of Pathology, Montefiore Medical Center, Bronx, New York

Search for more papers by this author

Daniel A. Weiser MD,

Daniel A. Weiser MD

Departments of Pediatrics and Genetics, Albert Einstein College of Medicine, Bronx, New York

Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Bronx, New York

Search for more papers by this author

First published: 22 May 2015

https://doi.org/10.1002/pbc.25586

Citations: 9

Conflict of interest: Nothing to declare.

Share a link

Email
Wechat
Bluesky

Abstract

Meigs syndrome, the combination of benign ovarian tumor, ascites, and pleural effusion, is present in a small percentage of ovarian fibromas and is infrequently reported in children. When associated with elevated CA-125 suspicion is raised for malignancy, often prompting aggressive surgical intervention. We present a case of childhood Meigs syndrome and review the relevant literature with emphasis on ovary preservation. Out of nine identified pediatric cases, one involved ovary sparing treatment and none recurred or progressed to malignancy. Our report highlights the importance of presurgical identification of Meigs syndrome in order to curtail salpingo-oophorectomy when feasible. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.

REFERENCES

1 Fallat ME, Ignacio Jr RC. Ovarian tumors. In: P Puri, M Hollwarth, editors. Pediatric surgery: Diagnosis and management. Springer 2009.
Google Scholar
2 Lass A. The fertility potential of women with a single ovary. Hum Reprod Update 1999; 5: 546–550.
10.1093/humupd/5.5.546
CAS PubMed Web of Science® Google Scholar
3 Eskander RN, Bristow RE, Saenz NC, Saenz CC. A retrospective review of the effect of surgeon specialty on the management of 190 benign and malignant pediatric and adolescent adnexal masses. J Pediatr Adolesc Gynecol 2011; 24: 282–285.
10.1016/j.jpag.2011.03.012
PubMed Web of Science® Google Scholar
4 Gibbs RS, Danforth DN. Danforth's obstetrics and gynecology. 10th ed Philadelphia: Lippincott Williams & Wilkins. xvi 2008. 1136 p. 8 p. of plates.
Google Scholar
5 Chechia A, Attia L, Temime RB, Makhlouf T, Koubaa A. Incidence, clinical analysis, and management of ovarian fibromas and fibrothecomas. Am J Obstet Gynecol 2008; 199: 473.e1–e4. doi: 10.1016/j.ajog.2008.03.053.
10.1016/j.ajog.2008.03.053
PubMed Web of Science® Google Scholar
6 Templeman C, Fallat ME, Blinchevsky A, Hertweck SP. Noninflammatory ovarian masses in girls and young women. Obstet Gynecol 2000; 96: 229–233.
10.1016/S0029-7844(00)00929-7
CAS PubMed Web of Science® Google Scholar
7 Meigs JV, Cass JW. Fibroma of the ovary with ascites and hydrothorax; with a report of 7 cases. Am J Obstet Gynecol 1937; 33.
Google Scholar
8 Meigs JV. Fibroma of the ovary with ascites and hydrothorax; Meigs' syndrome. Am J Obstet Gynecol 1954; 67: 962–985.
10.1016/0002-9378(54)90258-6
CAS PubMed Web of Science® Google Scholar
9 Sugiyama A, Urushihara N, Fukumoto K, Fukuzawa H, Nagae H, Watanabe K, Mitsunaga M, Hasegawa S, Koyama M. Ovarian fibroma with marked ascites and elevated serum levels of CA-125 in a young girl. J Pediatr Surg 2011; 46: 1001–1004.
10.1016/j.jpedsurg.2011.02.054
Google Scholar
10 Slovin I, Nealon J. Meigs' Syndrome; a case report. Del Med J 1951; 23: 8–10.
Google Scholar
11 Latta RJ, Lee PD. Meigs' syndrome in a young woman. J Adolesc Health Care 1981; 1: 313–315.
10.1016/S0197-0070(81)80012-5
Google Scholar
12 Chan CY, Chan SM, Liauw L. A large abdominal mass in a young girl. Br J Radiol 2000; 73: 913–914.
10.1259/bjr.73.872.11026873
CAS PubMed Web of Science® Google Scholar
13 Bildirici K, Yalcin OT, Ozalp SS, Peker B, Ozden H. Sclerosing stromal tumor of the ovary associated with Meigs' syndrome: A case report. Eur J Gynaecol Oncol 2004; 25: 528–529.
CAS PubMed Web of Science® Google Scholar
14 Liou JH, Su TC, Hsu JC. Meigs' syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor. Taiwan J Obstet Gynecol 2011; 50: 196–200.
10.1016/j.tjog.2011.01.011
Google Scholar
15 Monteiro SB, Costa A, Paiva V. Mitotically active cellular ovarian fibroma with Meigs' syndrome and elevated CA-125: Towards fertility preservation. J Pediatr Adolesc Gynecol 2012; 25: e107–e109.
10.1016/j.jpag.2012.05.012
Google Scholar
16 Gomes Sobrinho DB, Vasconcelos RG, Carvalho BR, Furtado VM, Ramos FA, Silva Netto JP, Freitas MA. Sclerosing stromal tumor of the ovary associated with a Meigs' syndrome and pregnancy: A case report Rev Bras Ginecol Obstet 2013; 35 331–335.
Google Scholar
17 Kitajima K, Kaji Y, Sugimura K. Usual and unusual MRI findings of ovarian fibroma: Correlation with pathologic findings. Magn Reson Med Sci 2008; 7: 43–48.
10.2463/mrms.7.43
PubMed Google Scholar
18 Tanaka YO, Nishida M, Yamaguchi M, Kohno K, Saida Y, Itai Y. MRI of gynaecological solid masses. Clin Radiol 2000; 55: 899–911.
10.1053/crad.2000.0600
CAS PubMed Web of Science® Google Scholar
19 Yen P, Khong K, Lamba R, Corwin MT, Gerscovich EO. Ovarian fibromas and fibrothecomas: sonographic correlation with computed tomography and magnetic resonance imaging: A 5-year single-institution experience. J Ultrasound Med 2013; 32: 13–18.
10.7863/jum.2013.32.1.13
PubMed Web of Science® Google Scholar
20 Jacobs I, Bast RC, Jr. The CA 125 tumour-associated antigen: A review of the literature. Hum Reprod 1989; 4: 1–12.
10.1093/oxfordjournals.humrep.a136832
CAS PubMed Web of Science® Google Scholar
21 Cho YJ, Lee HS, Kim JM, Lee SY, Song T, Seong SJ, Kim ML. Ovarian-sparing local mass excision for ovarian fibroma/fibrothecoma in premenopausal women. Eur J Obstet Gynecol Reprod Biol 2015; 185: 78–82.
10.1016/j.ejogrb.2014.11.042
Google Scholar
22 Papic JC, Finnell SM, Slaven JE, Billmire DF, Rescorla FJ, Leys CM. Predictors of ovarian malignancy in children: Overcoming clinical barriers of ovarian preservation. J Pediatr Surg 2014; 49: 144–147. discussion 147-8.
10.1016/j.jpedsurg.2013.09.068
Google Scholar

Citing Literature

Volume62, Issue11

November 2015

Pages 2011-2014

Ovary preservation in the treatment of childhood Meigs syndrome

Abstract

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Ovary preservation in the treatment of childhood Meigs syndrome

Abstract

REFERENCES

Citing Literature

References

Related

Information