Quality of life in young patients after bone tumor surgery around the knee joint and comparison with healthy controls†
Corresponding Author
W. Peter Bekkering PT
Department of Physical Therapy of the Leiden University Medical Center, Leiden, the Netherlands
Department of Physical Therapy, HO-Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.===Search for more papers by this authorTheodora P.M. Vliet Vlieland PhD
Department of Orthopaedics of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorHendrik M. Koopman PhD
Department of Medical Psychology of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorGerard R. Schaap MD, PhD
Department of Orthopedics of the Academic Medical Center University of Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorH.W. Bart Schreuder MD, PhD
Department of Orthopaedics of the Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Search for more papers by this authorAuke Beishuizen MD, PhD
Department of Pediatric Oncology/Hematology of the Erasmus MC University Medical Center/Sophia Children's Hospital, Rotterdam, the Netherlands
Search for more papers by this authorWim J.E. Tissing MD, PhD
Dept of Pediatric Oncology/Hematology, Beatrix Children's Hospital, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands
Search for more papers by this authorPeter M. Hoogerbrugge MD, PhD
Department of Paediatric Haemato-Oncology of the Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Search for more papers by this authorJacob K. Anninga MD
Department of Pediatric Hemato-Oncology of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorAntonie H.M. Taminiau MD, PhD
Department of Orthopaedics of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorCorresponding Author
W. Peter Bekkering PT
Department of Physical Therapy of the Leiden University Medical Center, Leiden, the Netherlands
Department of Physical Therapy, HO-Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.===Search for more papers by this authorTheodora P.M. Vliet Vlieland PhD
Department of Orthopaedics of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorHendrik M. Koopman PhD
Department of Medical Psychology of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorGerard R. Schaap MD, PhD
Department of Orthopedics of the Academic Medical Center University of Amsterdam, Amsterdam, the Netherlands
Search for more papers by this authorH.W. Bart Schreuder MD, PhD
Department of Orthopaedics of the Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Search for more papers by this authorAuke Beishuizen MD, PhD
Department of Pediatric Oncology/Hematology of the Erasmus MC University Medical Center/Sophia Children's Hospital, Rotterdam, the Netherlands
Search for more papers by this authorWim J.E. Tissing MD, PhD
Dept of Pediatric Oncology/Hematology, Beatrix Children's Hospital, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands
Search for more papers by this authorPeter M. Hoogerbrugge MD, PhD
Department of Paediatric Haemato-Oncology of the Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Search for more papers by this authorJacob K. Anninga MD
Department of Pediatric Hemato-Oncology of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorAntonie H.M. Taminiau MD, PhD
Department of Orthopaedics of the Leiden University Medical Center, Leiden, the Netherlands
Search for more papers by this authorConflict of interest: The authors have no conflicts of interest to declare.
Abstract
Background
This study aimed to compare the health related quality of life (HRQoL) of children and adolescents after malignant bone tumor surgery of the leg with healthy controls.
Procedure
Patients between 8 and 25 years old were cross-sectional recruited. Patients under 16 years of age received the TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Center) Children's Quality of Life Questionnaire (TACQOL), patients aged 16 years and older received the TNO-AZL Questionnaire for Adult's Quality of Life (TAAQOL) and the Short Form-36 (SF-36). Three age- and sex-matched normative random samples, drawn from large, nationwide studies, were used for the comparison with healthy controls. Patients were interviewed regarding their most important problems related to the disease and its treatment.
Results
Eighty-one patients with a mean age of 16.9 years (SD 4.2) were included (41 female). Limb sparing surgery was executed in 38 patients, ablative surgery in 43 patients. In comparison with healthy controls, patients had significantly poorer HRQoL within the domains autonomy and motor function of the TACQOL, gross motor function, cognitive functioning, daily functioning and sexuality of the TAAQOL, and physical functioning, role physical, general health, and the physical and mental component summary scales of the SF-36. Patients reported limitations in physical activities, participation in sports, and cosmetic aspects as the most detrimental consequences of their disease and its treatment.
Conclusion
In children and adolescents who underwent surgery for a malignant tumor of the leg physical, functioning was significantly impaired as compared to healthy controls. Pediatr Blood Cancer 2010;54:738–745. © 2010 Wiley-Liss, Inc.
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