Research Article

Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia^†

Corresponding Author

Amanda M. Termuhlen MD

[email protected]

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

ED 554, Education Building, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205.===Search for more papers by this author

Kathryn Klopfenstein MD,

Kathryn Klopfenstein MD

Department of Pediatrics, East Tennessee State University, Johnson City, Tennessee

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Randall Olshefski MD,

Randall Olshefski MD

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Robin Rosselet MSN, FNP,

Robin Rosselet MSN, FNP

Nationwide Children's Hospital, Columbus, Ohio

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Nicholas D. Yeager MD,

Nicholas D. Yeager MD

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Sandeep Soni MBBS,

Sandeep Soni MBBS

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Thomas G. Gross MD, PhD,

Thomas G. Gross MD, PhD

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Amanda M. Termuhlen MD,

Corresponding Author

Amanda M. Termuhlen MD

[email protected]

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

ED 554, Education Building, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205.===Search for more papers by this author

Kathryn Klopfenstein MD,

Kathryn Klopfenstein MD

Department of Pediatrics, East Tennessee State University, Johnson City, Tennessee

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Randall Olshefski MD,

Randall Olshefski MD

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Robin Rosselet MSN, FNP,

Robin Rosselet MSN, FNP

Nationwide Children's Hospital, Columbus, Ohio

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Nicholas D. Yeager MD,

Nicholas D. Yeager MD

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Sandeep Soni MBBS,

Sandeep Soni MBBS

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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Thomas G. Gross MD, PhD,

Thomas G. Gross MD, PhD

Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

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First published: 20 May 2008

https://doi.org/10.1002/pbc.21614

Citations: 10

^†

Presented in abstract form at the American Society for Blood and Marrow Transplantation Annual Meeting, Keystone, Colorado, February 2007.

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Abstract

Background

Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown.

Procedure

Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg × 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning.

Results

All five patients remain in molecular remission a median of 20 months post-transplant.

Conclusion

Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation. Pediatr Blood Cancer 2008;51:521–524. © 2008 Wiley-Liss, Inc.

REFERENCES

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Citing Literature

Volume51, Issue4

October 2008

Pages 521-524

Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia^†

Abstract

Background

Procedure

Results

Conclusion

REFERENCES

Citing Literature

References

Information

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Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia†

Abstract

Background

Procedure

Results

Conclusion

REFERENCES

Citing Literature

References

Related

Information

Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia^†