Should ovarian cryopreservation be offered to girls with cancer†
Corresponding Author
Michael Weintraub MD
Pediatric Hematology-Oncology unit, Hadassah University Medical Center, Jerusalem, Israel
Pediatric Hematology-Oncology, Hadassah University Medical Center, Kiryat Hadassah, P.O. 12000 Jerusalem 91120, Israel.===Search for more papers by this authorEitan Gross MD
Pediatric Surgery Department, Hadassah University Medical Center, Jerusalem, Israel
Search for more papers by this authorAvishag Kadari MD
Department of Anaesthesiology, Hadassah University Medical Center, Jerusalem, Israel
Search for more papers by this authorVardit Ravitsky PhD
Graduate Program in Bioethics, Bar Ilan University, Ramat Gan, Israel
Search for more papers by this authorAnat Safran PhD
Department of Obstetrics and Gynecology, Hadassah University Medical, Center, Jerusalem, Israel
Search for more papers by this authorNeri Laufer MD
Department of Obstetrics and Gynecology, Hadassah University Medical, Center, Jerusalem, Israel
Search for more papers by this authorAriel Revel MD
Department of Obstetrics and Gynecology, Hadassah University Medical, Center, Jerusalem, Israel
Search for more papers by this authorCorresponding Author
Michael Weintraub MD
Pediatric Hematology-Oncology unit, Hadassah University Medical Center, Jerusalem, Israel
Pediatric Hematology-Oncology, Hadassah University Medical Center, Kiryat Hadassah, P.O. 12000 Jerusalem 91120, Israel.===Search for more papers by this authorEitan Gross MD
Pediatric Surgery Department, Hadassah University Medical Center, Jerusalem, Israel
Search for more papers by this authorAvishag Kadari MD
Department of Anaesthesiology, Hadassah University Medical Center, Jerusalem, Israel
Search for more papers by this authorVardit Ravitsky PhD
Graduate Program in Bioethics, Bar Ilan University, Ramat Gan, Israel
Search for more papers by this authorAnat Safran PhD
Department of Obstetrics and Gynecology, Hadassah University Medical, Center, Jerusalem, Israel
Search for more papers by this authorNeri Laufer MD
Department of Obstetrics and Gynecology, Hadassah University Medical, Center, Jerusalem, Israel
Search for more papers by this authorAriel Revel MD
Department of Obstetrics and Gynecology, Hadassah University Medical, Center, Jerusalem, Israel
Search for more papers by this authorPresented at the Israeli Fertility Society Meeting, Tel Aviv, 2003, and at the Israeli Society for Pediatric Hematology-Oncology, Tel Aviv, 2004
Abstract
Current therapy of childhood cancer makes long-term survival a realistic outcome for most patients. However, some treatment regimens entail a significant risk of infertility. No established method for preservation of female fertility is currently available. Ovarian cryopreservation is an experimental technology that is being offered with increasing frequency to women undergoing cancer therapy. It has not yet been reported in children and adolescent girls. The aim of this review is to stimulate discussion on the possibility of performing ovarian cryopreservation in pre-menarcheal girls in advance of therapies that may induce ovarian failure. We present a multi-disciplinary discussion of the risks and benefits associated with the procedure and propose guidelines for its implementation. We propose that all girls about to receive treatment that has a high risk for infertility be offered consultation about the possibility of ovarian cryopreservation. Pediatr Blood Cancer 2007;48:4–9. © 2006 Wiley-Liss, Inc.
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