β-Carotene-reinforced Poly(methyl methacrylate): A step forward in bioactive bone cements
Corresponding Author
Elia Marin
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Correspondence
Elia Marin, Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8585 Kyoto, Japan.
Email: [email protected]
Search for more papers by this authorDaniel Muhammad Bin Idrus
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Search for more papers by this authorFrancesco Boschetto
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, Kyoto, Japan
Search for more papers by this authorTaigi Honma
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, Kyoto, Japan
Search for more papers by this authorTetsuya Adachi
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Search for more papers by this authorAlex Lanzutti
Department Polytechnic of Engineering and Architecture, University of Udine, Udine, Italy
Search for more papers by this authorAlfredo Rondinella
Department Polytechnic of Engineering and Architecture, University of Udine, Udine, Italy
Search for more papers by this authorWenliang Zhu
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Search for more papers by this authorTatsuro Morita
Department of Mechanical Engineering, Kyoto Institute of Technology, Kyoto, Japan
Search for more papers by this authorNarisato Kanamura
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Search for more papers by this authorToshiro Yamamoto
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Search for more papers by this authorGiuseppe Pezzotti
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, Kyoto, Japan
The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan
Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Elia Marin
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Correspondence
Elia Marin, Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8585 Kyoto, Japan.
Email: [email protected]
Search for more papers by this authorDaniel Muhammad Bin Idrus
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Search for more papers by this authorFrancesco Boschetto
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, Kyoto, Japan
Search for more papers by this authorTaigi Honma
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, Kyoto, Japan
Search for more papers by this authorTetsuya Adachi
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Search for more papers by this authorAlex Lanzutti
Department Polytechnic of Engineering and Architecture, University of Udine, Udine, Italy
Search for more papers by this authorAlfredo Rondinella
Department Polytechnic of Engineering and Architecture, University of Udine, Udine, Italy
Search for more papers by this authorWenliang Zhu
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Search for more papers by this authorTatsuro Morita
Department of Mechanical Engineering, Kyoto Institute of Technology, Kyoto, Japan
Search for more papers by this authorNarisato Kanamura
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Search for more papers by this authorToshiro Yamamoto
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Search for more papers by this authorGiuseppe Pezzotti
Ceramic Physics Laboratory, Kyoto Institute of Technology, Kyoto, Japan
Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kamigyo-ku, Kyoto, Japan
The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan
Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan
Search for more papers by this authorAbstract
By making use of the outstanding osteoinductive effects of β-carotene, in this innovative research, we investigate the potential for application of β-carotene-reinforced PMMA resins. Different amounts of β-carotene, from 0% to 5%, have been mixed with standard bone cements and characterized by various spectroscopic and microscopic techniques before testing with KUSA-A1 murine mesenchymal cells. In vitro results showed that not only the amount of bone produced by the cells on the composite is comparable if not superior to modern bioglasses but also both adhesion and cellular proliferation are strongly promoted by the presence of β-carotene. The increased biological properties came at the price of a small loss in elastic modulus, but it was observed that the presence of β-carotene leads to an increase of ultimate strength, reaching an increase of about 30% at a concentration of about 2.5%. The enhanced bioactivity and mechanical strength make β-carotene-reinforced PMMA a promising, innovative material for biomedical applications.
CONFLICT OF INTEREST STATEMENT
The authors declare that they have no competing interests.
Open Research
DATA AVAILABILITY STATEMENT
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| pat6500-sup-0001-Supinfo.docxWord 2007 document , 2.1 MB | Data S1. Supporting Information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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