Development of natural product (1 → 3)-β-D-glucan polymers as immune-stimulating pharmaceuticals
David L. Williams PhD
Glucan Research Laboratory, Department of Surgery, James H. Quillen College of Medicine, Box 70, 575, East Tennessee State University, Johnson City, Tennessee 37604-0575, USA
Search for more papers by this authorI. William Browder Md
Glucan Research Laboratory, Department of Surgery, James H. Quillen College of Medicine, Box 70, 575, East Tennessee State University, Johnson City, Tennessee 37604-0575, USA
Search for more papers by this authorDavid L. Williams PhD
Glucan Research Laboratory, Department of Surgery, James H. Quillen College of Medicine, Box 70, 575, East Tennessee State University, Johnson City, Tennessee 37604-0575, USA
Search for more papers by this authorI. William Browder Md
Glucan Research Laboratory, Department of Surgery, James H. Quillen College of Medicine, Box 70, 575, East Tennessee State University, Johnson City, Tennessee 37604-0575, USA
Search for more papers by this authorAbstract
Glucan phosphate is a water-soluble, yeast-derived, (1 → 3)-β-D-glucopyranose polymer that has been demonstrated to be a potent immune stimulant. Glucan phosphate administration is associated with stimulation of immunity and a concomitant increase in resistance to a variety of experimentally induced disease states. Preclinical safety evaluation indicates that glucan phosphate does not induce mortality or significant toxicity over a wide dose range. Phase I clinical data indicate that glucan phosphate will ameliorate immunosuppression, stimulate immunity, decrease susceptibility to infection and alter ultimate outcome in trauma patients following laparotomy or thoracotomy. This work reviews the development, characterization, preclinal and clinical evaluation of glucan phosphate.
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