Changes in the expression of meteorin-like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery
Corresponding Author
Mohammad H. Jamal
Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Department of Organ Transplant, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Department of Surgery, Jaber Al-Ahmed Hospital, Kuwait City, Kuwait
Correspondence
Mohammad H. Jamal, Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Safat 13110 Kuwait City, Kuwait.
Email: [email protected]
Search for more papers by this authorFatemah AlOtaibi
Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorCarol Dsouza
Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorSuleiman Al-Sabah
Department of Pharmacology and Toxicology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorGhanim Al-Khaledi
Department of Pharmacology and Toxicology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorWaleed Al-Ali
Department of Pathology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorHamad Ali
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorPreethi Cherian
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorIrina Al-Khairi
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorSriraman Devarajan
Special Service Facility, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorMohamed Abu-Farha
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorFahd Al-Mulla
Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorJehad Abubaker
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorCorresponding Author
Mohammad H. Jamal
Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Department of Organ Transplant, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Department of Surgery, Jaber Al-Ahmed Hospital, Kuwait City, Kuwait
Correspondence
Mohammad H. Jamal, Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Safat 13110 Kuwait City, Kuwait.
Email: [email protected]
Search for more papers by this authorFatemah AlOtaibi
Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorCarol Dsouza
Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorSuleiman Al-Sabah
Department of Pharmacology and Toxicology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorGhanim Al-Khaledi
Department of Pharmacology and Toxicology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorWaleed Al-Ali
Department of Pathology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Search for more papers by this authorHamad Ali
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait
Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorPreethi Cherian
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorIrina Al-Khairi
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorSriraman Devarajan
Special Service Facility, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorMohamed Abu-Farha
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorFahd Al-Mulla
Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorJehad Abubaker
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait
Search for more papers by this authorFunding information: Kuwait Foundation for the Advancement of Sciences (KFAS) (Project No-P116-13MM-06)
Abtract
Objective
Bariatric surgery is currently the most effective treatment for severe obesity. This study aims to investigate the changes in expression levels of meteorin-like protein (METRNL), irisin (FNDC5), and uncoupling proteins (UCP) 1/2/3 following bariatric surgery to understand their involvement in enhancing metabolism after surgery.
Method
A total of 40 participants were enrolled in this interventional study, 20 with obesity BMI ≥ 35 kg/m2 and 20 with BMI ≤ 25 kg/m2. Bariatric surgery (laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass) was performed. The levels of various molecules of interest were analyzed before and after surgery.
Results
Gene expression analysis revealed significantly higher levels of METRNL, UCP1, and UCP3 in individuals with obesity when compared with healthy individuals before surgery (p < 0.05). Gene expression levels of METRNL and UCP2 showed a significant increase after bariatric surgery (p < 0.05). METRNL plasma level was significantly higher in individuals with obesity before surgery (mean [SEM], 55,222.6 [1,421.1] pg/mL, p = 0.0319), as well as at 6 and 12 months (57,537.3 [1,303.9] pg/mL, p = 0.0005; 59,334.9 [1,214.3] pg/mL, p < 0.0001) after surgery.
Conclusion
The changes in the levels of various molecules of interest support their possible involvement in the inflammatory and thermogenic responses following bariatric surgery.
CONFLICT OF INTEREST
The authors declared no conflict of interest.
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