An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the assessment of sexual health of women with pelvic floor dysfunction
Corresponding Author
Rebecca G. Rogers MD
Dell Medical School, University of Texas, Austin, Texas
Correspondence
Rebecca G. Rogers, Department of Women's Health, 1301 W 38th Street, Suit705, Dell Medical School, University of Texas, Austin, TX 78705.
Email: [email protected]
Search for more papers by this authorRachel N. Pauls MD
TriHealth Good Samaritan Hospital, Cincinnati, Ohio
Search for more papers by this authorRanee Thakar MD
Croydon University Hospital Croydon, London, United Kingdom
Search for more papers by this authorMelanie Morin PhD
Universite de Sherbrooke, Montreal, Quebec, Canada
Search for more papers by this authorAnnette Kuhn MD
University Teaching Hospital Berne (Inselspital), Bern, Switzerland
Search for more papers by this authorEckhard Petri Dd, PhD
University of Greifswald, Schwerin, Germany
Search for more papers by this authorBrigitte Fatton MD
University Hospital Nîmes, Nimes, Languedoc-Roussillon, France
Search for more papers by this authorKristene Whitmore MD
Drexel University College of Medicine, Philadelphia, Pennsylvania
Search for more papers by this authorSheryl Kinsberg PhD
Case Western Reserve University, Cleveland, Ohio
Search for more papers by this authorJoseph Lee MBChB, FRANZCOG
University of New South Wales, St Vincents Hospital, Sydney, New South Wales, Australia
Search for more papers by this authorCorresponding Author
Rebecca G. Rogers MD
Dell Medical School, University of Texas, Austin, Texas
Correspondence
Rebecca G. Rogers, Department of Women's Health, 1301 W 38th Street, Suit705, Dell Medical School, University of Texas, Austin, TX 78705.
Email: [email protected]
Search for more papers by this authorRachel N. Pauls MD
TriHealth Good Samaritan Hospital, Cincinnati, Ohio
Search for more papers by this authorRanee Thakar MD
Croydon University Hospital Croydon, London, United Kingdom
Search for more papers by this authorMelanie Morin PhD
Universite de Sherbrooke, Montreal, Quebec, Canada
Search for more papers by this authorAnnette Kuhn MD
University Teaching Hospital Berne (Inselspital), Bern, Switzerland
Search for more papers by this authorEckhard Petri Dd, PhD
University of Greifswald, Schwerin, Germany
Search for more papers by this authorBrigitte Fatton MD
University Hospital Nîmes, Nimes, Languedoc-Roussillon, France
Search for more papers by this authorKristene Whitmore MD
Drexel University College of Medicine, Philadelphia, Pennsylvania
Search for more papers by this authorSheryl Kinsberg PhD
Case Western Reserve University, Cleveland, Ohio
Search for more papers by this authorJoseph Lee MBChB, FRANZCOG
University of New South Wales, St Vincents Hospital, Sydney, New South Wales, Australia
Search for more papers by this authorAbstract
Aims
The terminology in current use for sexual function and dysfunction in women with pelvic floor disorders lacks uniformity, which leads to uncertainty, confusion, and unintended ambiguity. The terminology for the sexual health of women with pelvic floor dysfunction needs to be collated in a clinically-based consensus report.
Methods
This report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA), and the International Continence Society (ICS), assisted at intervals by many external referees. Internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Importantly, this report is not meant to replace, but rather complement current terminology used in other fields for female sexual health and to clarify terms specific to women with pelvic floor dysfunction.
Results
A clinically based terminology report for sexual health in women with pelvic floor dysfunction encompassing over 100 separate definitions, has been developed. Key aims have been to make the terminology interpretable by practitioners, trainees, and researchers in female pelvic floor dysfunction. Interval review (5-10 years) is anticipated to keep the document updated and as widely acceptable as possible.
Conclusion
A consensus-based terminology report for female sexual health in women with pelvic floor dysfunction has been produced aimed at being a significant aid to clinical practice and a stimulus for research.
CONFLICTS OF INTEREST
RG Rogers, Royalties from UPTODATE; R Pauls, no disclosures; R Thakar, Vice President of the International Urogynecological Association, Honorariums from Astellas and Pfizer for lectures; M Morin, no disclosures; A Kuhn, no disclosures; E Petri, no disclosures; B Fatton, consultant for Astellas, Allergan, Boston Scientific; K Whitmore: Clinical Research, Coloplast, Allergan; S Kingsberg, Paid consultant to: Apricus, Emotional Brain, Sprout, Teva, SST, Pfizer, Shionogi, Novo Nordisk, Viveve, Palatin, Metagenenics; Stock options, Viveve; J Lee, Research Grant from AMS/BSCI for investigator led clinical trials.
Supporting Information
Additional Supporting Information may be found online in the supporting information tab for this article.
Filename | Description |
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nau23508-0001-SupTab-S1.docx60.6 KB |
Table S1. Psychometric properties of the measurement of physiologic changes. |
nau23508-0002-SupTab-S2.docx66.2 KB |
Table S2. Representative clinical research for treatment of female sexual dysfunction. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1 Haylen BT, de Ridder D, Freeman RM, et al. An international urogynecological association (IUGA)/International continence society (ICS) joint report on the terminology for female pelvic floor dysfunction. Int Urogynecol J. 2010; 21: 5–26.
- 2 Shifren JL, Monz BU, Russo PA, Segretti A, Johannes CB. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008; 112: 970–997.
- 3 Basson R, Berman J, Burnett A, et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol. 2000; 163: 888–893.
- 4 Rupesh R, Pahlajani G, Khan S, Gupta S, Agarwal A, Zippe CD. Female sexual dysfunction: classification, pathophysiology and management. Fertil Steril. 2007; 88: 1273–1284.
- 5 Basson R, Althof S, Davis S, et al. Summary of the recommendations on sexual dysfunctions in women. J Sex Med. 2004; 1: 24–34.
- 6 Fashokun TB, Harvie HS, Schimpf MO, et al. Sexual activity and function in women with and without pelvic floor disorders. Int Urogynecol J. 2013; 24: 91–97.
- 7 Handa VL, Cundiff G, Chang HH, Helzlsouer KJ. Female sexual function and pelvic floor disorders. Obstet Gynecol. 2008; 111: 1045–1052.
- 8 Rogers RG. Sexual function in women with pelvic floor disorders. Can Urol Assoc J. 2013; 7: S199–S201.
- 9 Salonia A, Zanni G, Nappi RE, et al. Sexual dysfunction is common in women with lower urinary tract symptoms and urinary incontinence: results of a cross-sectional study. Eur Urol. 2004; 45: 642–648.
- 10 Lowenstein L, Gamble T, Sanses TV, et al. Sexual function is related to body image perception in women with pelvic organ prolapse. J Sex Med. 2009; 6: 2286–2291.
- 11 Jelovsek JE, Barber MD. Women seeking treatment for advanced pelvic organ prolapse have decreased body image and quality of life. Am J Obstet Gynecol. 2006; 194: 1455–1461.
- 12 Zielinski R, Miller J, Low LK, Sampselle C, DeLancey JO. The relationship between pelvic organ prolapse, genital body image, and sexual health. Neurourol Urodyn. 2012; 31: 1145–1148.
- 13 Lowenstein L, Pierce K, Pauls R. Urogynecology and sexual function research. How are we doing? J Sex Med. 2009; 6: 199–204.
- 14 Cichowski SB, Komesu YM, Dunivan GC, Rogers RG. The association between fecal incontinence and sexual activity and function in women attending a tertiary referral center. Int Urogynecol J. 2013; 24: 1489–1494.
- 15 Kingsberg SA, Knudson G. Female sexual disorders: assessment, diagnosis, and treatment. CNS Spectr. 2011; 16: 49–62.
- 16 Bortolami A, Vanti C, Banchelli F, Gruccione AA, Pillastrini P. Relationship between female pelvic floor dysfunction and sexual dysfunction: an observational study. J Sex Med. 2015; 12: 1233–1241.
- 17 Kanter G, Rogers RG, Pauls RN, Kammerer-Doak D, Thakar R. A strong pelvic floor is associated with higher rates of sexual activity in women with pelvic floor disorders. Int Urogynecol J. 2015; 26: 991–996.
- 18 Jha S, Ammenbal M, Metwally M. Impact of incontinence surgery on sexual function: a systematic review and meta-analysis. J Sex Med. 2012; 9: 34–43.
- 19 Lonnee-Hoffmann RA, Salvesen O, Morkved S, Schei B. What predicts improvement of sexual function after pelvic floor surgery? A follow-up study. Acta Obstet Gynecol Scand. 2013; 92: 1304–1312.
- 20 Jha S, Gray T. A systematic review and meta-analysis of the impact of native tissue repair for pelvic organ prolapse on sexual function. Int Urogynecol J. 2015; 26: 321–327.
- 21 Shaw C. A systematic review of the literature on the prevalence of sexual impairment in women with urinary incontinence and the prevalence of urinary leakage during sexual activity. Eur Urol. 2002; 42: 432–440.
- 22 Serati M, Salvatore S, Cattoni E, et al. Female urinary incontinence at orgasm: a possible marker of a more severe form of detrusor overactivity. Can ultrasound measurement of bladder wall thickness explain it? J Sex Med. 2011; 8: 1710–1716.
- 23 El-Azab AS, Yousef HA, Seifeldein GS. Coital incontinence: relation to detrusor overactivity and stress incontinence. Neurourol Urodyn. 2011; 30: 520–524.
- 24 Pastor Z. Female ejaculation orgasm vs. coital incontinence: a systematic review. J Sex Med. 2013; 10: 1682–1691.
- 25 Serati M, Cattoni E, Braga A, Siesto G, Salvatore S. Coital incontinence: relation to detrusor overactivity and stress incontinence. A controversial topic. Neurourol Urodyn. 2011; 30: 1415.
- 26 Serati M, Salvatore S, Uccella S, et al. Urinary incontinence at orgasm: relation to detrusor overactivity and treatment efficacy. Eur Urol. 2008; 54: 911–915.
- 27 Di Denato V, Manci N, Palaia I, et al. Urethral coitus in a patient with a microperforate hymen. JMIG. 2008; 15: 642–643.
- 28 Sultan AH, Monga A, Lee J, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female anorectal dysfunction. Int Urogynecol J. 2015; 28: 5–31.
- 29 Barber MD, Visco AG, Wyman JF, Fantl JA, Bump RC. Sexual function in women with urinary incontinence and pelvic organ prolapse. Obstet Gynecol. 2002; 99: 281–289.
- 30 Weber AM, Walters MD, Piedmonte MR. Sexual function and vaginal anatomy in women before and after surgery for pelvic organ prolapse and urinary incontinence. Am J Obstet Gynecol. 2000; 182: 1610–1615.
- 31 Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet. 2007; 369: 1027–1038.
- 32 Weber AM, Walters MD, Schover LR, Mitchinson A. Sexual Function in women with uterovaginal prolapse and urinary incontinence. Obstet Gynecol. 1995; 85: 483–487.
- 33 Pauls RN, Fellner AN, Davila GW. Vaginal laxity: a poorly understood quality of life problem; a survey of physician members of the International Urogynecological Association (IUGA). Int Urogynecol J. 2012; 23: 1435–1448.
- 34 Spector IP, Carey MP. Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav. 1990; 19: 389–408.
- 35 Basson R, Leiblum S, Brotto L, et al. Revised definitions of women's sexual dysfunction. J Sex Med. 2004; 1: 40–48.
- 36American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: Author; 2013.
- 37 Bornstein J, Goldstein AT, Stockdale CK, et al. 2015 ISSVD, ISSWSH, and IPPS consensus terminology and classification of persistent vulvar pain and vulvodynia. J Sex Med. 2016; 13: 607–612.
- 38 Brubaker L. Editorial: partner dyspareunia (Hispareunia). Int Urogynecol J Pelvic Floor Dysfunct. 2006; 17: 311.
- 39 Toozs-Hobson P, Freeman R, Barber M, et al. International Urogynecological Association, International Continence Society. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for reporting outcomes of surgical procedures for pelvic organ prolapse. Int Urogynecol J. 2012; 23: 527–535.
- 40 Haylen BT, Freeman RM, Swift SE, et al. An international urogynecological association (IUGA)/international continence society (ICS) joint terminology and classification of the complications related directly to the insertion of protheses (meshes, implants, tapes) and grafts in female pelvic floor surgery. Int Urogynecol J. 2011; 22: 3–15.
- 41 Devreese A, Staes F, De Weerdt W, et al. Clinical evaluation of pelvic floor muscle function in continent and incontinent women. Neurourol Urodyn. 2004; 23: 190–197.
- 42 Reissing ED, Brown C, Lord MJ, Binik YM, Khalifé S. Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. J Psychosom Obstet Gynaecol. 2005; 26: 107–113.
- 43 Messelink B, Benson T, Berghmans B, et al. Standardization of terminology of pelvic floor muscle function and dysfunction: report from the Pelvic Floor Clinical Assessment Group of the International Continence Society. Neurourol Urodyn. 2005; 24: 374–380.
- 44
Laycock J,
Jerwood D. Pelvic floor muscle assessment: the PERFECT scheme.
Physiotherapy.
2001;
87: 631–642.
10.1016/S0031-9406(05)61108-X Google Scholar
- 45 Brink CA, Wells TJ, Sampselle CM, Taillie ER, Mayer R. A digital test for pelvic muscle strength in women with urinary incontinence. Nurs Res. 1994; 43: 352–356.
- 46 Dietz HP, Moegni F, Shek KL. Diagnosis of levator avulsion injury: a comparison of three methods. Ultrasound Obstet Gynecol. 2012; 40: 693–698.
- 47 Simons DG, Mense S. Understanding and measurement of muscle tone as related to clinical muscle pain. Pain. 1998; 75: 1–17.
- 48 Bo K, Frawley H, Haylen B, et al. International (IUGA)/International continence society (ICS) joint report on the terminology for the conservative and non-Pharmacological management of female pelvic floor dysfunction. Int Urogynecol J. 2017; 28: 191–213.
- 49 Montenegro ML, Mateus-Vasconcelos EC, Rosa e Silva JC, Nogueira AA, Dos Reis FJ, Poli Neto OB. Importance of pelvic muscle tenderness evaluation in women with chronic pelvic pain. Pain Med. 2010; 11: 224–228.
- 50 Masi AT, Hannon JC. Human resting muscle tone (HRMT): narrative introduction and modern concepts. J Body Mov Ther. 2008; 12: 320–332.
- 51 Bottomley J. Quick reference dictionary for physical therapy. 3rd ed. New Jersey: SLACK Incorporated; 2013.
- 52 Howley ET. Type of activity: resistance, aerobic and leisure versus occupational physical activity. Med Sci Sports Exerc. 2001; 33: S364–S369.
- 53
Komi PV. Strength and power in sport. In:
Encyclopaedia of sports medicine. 2nd edn.
Oxford:
Blackwell Science Ltd;
2003.
10.1002/9780470757215 Google Scholar
- 54 Wilmore JH, Costill DL. Neuromuscular adaptations to resistance training. Physiology of sport and exercise. 2nd Ed. Chapter 3, USA: Human Kinetics; 1999. 82–111.
- 55 Basson R, Leiblum S, Brotto L, et al. Definitions of women's sexual dysfunction reconsidered: advocating expansion and revision. J Psychosom Obstet Gynaecol. 2003; 24: 221–229.
- 56 Kingsberg SA, Althof SE. Satisfying sexual events as outcome measures in clinical trial of female sexual dysfunction. Behav Res Ther. 2011; 49: 352–360.
- 57 Brookes ST, Donovan JL, Wright M, Jackson S, Abrams P. A scored form of the Bristol Female Lower Urinary Tract Symptoms Questionnaire: data from a randomized controlled trial of surgery for women with stress incontinence. Am J Obstet Gynecol. 2004; 191: 73–82.
- 58 Rust J, Golombok S. The colombok-Rust inventory of sexual satisfaction (GRISS). Br J Clin Psychol. 1985; 24: 63–64.
- 59 Price N, Jackson SR, Avery K, Brookes ST, Abrams P. Development and psychometric evaluation of the ICIQ vaginal symptoms questionnaire: the ICIQ-VS. BJOG. 2006; 113: 700–712.
- 60 Rogers RG, Kammerer-Doak D, Villarreal A, Coates K, Qualls C. A new instrument to measure sexual function in women with urinary incontinence or pelvic organ prolapse. Am J Obstet Gynecol. 2001; 184: 552–558.
- 61 Rogers RG, Coates KW, Kammerer-Doak D, Khalsa S, Qualls C. A short form of the pelvic organ prolapse/urinary incontinence sexual questionnaire (PISG-12). Int Urogynocol J Pelvic Floor Dysfunct. 2003; 14: 164–168.
- 62 Rosen RC, Brown C, Heman J, et al. The female sexual function index (FSFI): a multi-centered self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000; 26: 191–208.
- 63 Quirk FH, Heiman JR, Rosen RC, et al. Development of a sexual function questionnaire for clinical trials of female sexual dysfunction. J Womens Health Gend Based Med. 2002; 11: 277–289.
- 64 Berman JR. Physiology of female sexual function and dysfunction. Int J Impot Res. 2005; 17: S44–S51.
- 65 Park K, Goldstein I, Andry C, Siroky MB, Krane RJ, Azadzoi KM. Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res. 1997; 9: 27–37.
- 66 Ottesen B, Pedersen B, Nielsen J, Dalgaard D, Wagner G, Fahrenkrug J. Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women. Peptides. 1987; 8: 797–800.
- 67 Laan E, Everaerd W, Evers A. Assessment of female sexual arousal: response specificity and construct validity. Psychophysiology. 1995; 32: 476–485.
- 68 Rosen RC. Assessment of female sexual dysfunction: review of validated methods. Fertil Steril. 2002; 77: S89–S93.
- 69 Prause N, Cerny J, Janssen E. The labial photoplethysmograph: a new instrument for assessing genital hemodynamic changes in women. J Sex Med. 2005; 2: 58–65.
- 70 Gerritsen J, van der Made F, Bloemers J, et al. The clitoral photoplethysmograph: a new way of assessing genital arousal in women. J Sex Med. 2009; 6: 1678–1687.
- 71 Garcia S, Talakoub L, Maitland S, Dennis A, Goldstein I, Munarriz R. Genital duplex doppler ultrasonography before and after sexual stimulation in women with sexual dysfunction: gray scale, volumetric, and hemodynamic findings. Fertil Steril. 2005; 83: 995–999.
- 72 Khalife S, Binik YM, Cohen DR, Amsel R. Evaluation of clitoral blood flow by color Doppler ultrasonography. J Sex Marital Ther. 2000; 26: 187–189.
- 73 Kukkonen TM, Paterson L, Binik YM, Amsel R, Bouvier F, Khalife S. Convergent and discriminant validity of clitoral color Doppler ultrasonography as a measure of female sexual arousal. J Sex Marital Ther. 2006; 32: 281–287.
- 74 Berman JR, Berman LA, Lin H, et al. Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder. J Sex Marital Ther. 2001; 27: 411–420.
- 75 Waxman SE, Pukall CF. Laser Doppler imaging of genital blood flow: a direct measure of female sexual arousal. J Sex Med. 2009; 6: 2278–2285.
- 76 Bohm-Starke N, Hilliges M, Blomgren B, Flaconer C, Rylander E. Increased blood flow and erythema in the posterior vestibular mucosa in vulvar vestibulitis (1). Obstet Gynecol. 2001; 98: 1067–1074.
- 77 Maravilla KR, Yang CC. Magnetic resonance imaging and the female sexual response: overview of techniques, results, and future directions. J Sex Med. 2008; 5: 1559–1571.
- 78 Sommer F, Caspers HP, Esders K, Klotz T, Engelmann U. Measurement of vaginal and minor labial oxygen tension for the evaluation of female sexual function. J Urol. 2001; 165: 1181–1184.
- 79 Levin RJ, Wagner G. Haemodynamic changes of the human vagina during sexual arousal assessed by a heated oxygen electrode [proceedings]. J Physiol. 1978; 275: 23P–24P.
- 80 Prause N, Heiman JR. Assessing female sexual arousal with the labial thermistor: response specificity and construct validity. Int J Psychophysiol. 2009; 72: 115–122.
- 81 Payne KA, Binik YM. Reviving the labial thermistor clip. Arch Sex Behav. 2006; 35: 111–113.
- 82 Kukkonen TM, Binik YM, Amsel R, Carrier S. Thermography as a physiological measure of sexual arousal in both men and women. J Sex Med. 2007; 4: 93–105.
- 83 Kukkonen TM, Binik YM, Amsel R, Carrier S. An evaluation of the validity of thermography as a physiological measure of sexual arousal in a non-university adult sample. Arch Sex Behav. 2010; 39: 861–873.
- 84 Romanzi LJ, Groutz A, Feroz F, Blaivas JG. Evaluation of female external genitalia sensitivity to pressure/touch: a preliminary prospective study using Semmes-Weinstein monofilaments. Urology. 2001; 57: 1145–1150.
- 85 Leedom L, Feldman M, Procci W, Zeidler A. Symptoms of sexual dysfunction and depression in diabetic women. J Diabet Complications. 1991; 5: 38–41.
- 86 Sipski ML, Alexander CJ. Sexual activities, response and satisfaction in women pre- and post-spinal cord injury. Arch Phys Med Rehabil. 1993; 74: 1025–1029.
- 87 Vardi Y, Gruenwald I, Sprecher E, Gertman I, Yartnitsky D. Normative values for female genital sensation. Urology. 2000; 56: 1035–1040.
- 88 Cordeau D, Belanger M, Beaulieu-Prevost D, Courtois F. The assessment of sensory detection thresholds on the perineum and Breast compared with control body sites. J Sex Med. 2014; 11: 1741–1748.
- 89 Lundberg PO, Ertekin C, Ghezzi A, Swash M, Vodusek D. Neurosexology: guidelines for neurologists. European Journal of Neurology. 2001; 8: 2–24.
- 90 Tas I, On Yagiz, Altay B, Ozdedeli K. Electrophysiological assessment of sexual dysfunction in spinal cord injured patients. Spinal Cord. 2007; 45: 298–303.
- 91 Messe MR, Geer JH. Voluntary vaginal musculature contractions as an enhancer of sexual arousal. Arch Sex Behav. 1985; 14: 13–28.
- 92 Graber B, Kline-Graber G. Female orgasm: role of pubococcygeus muscle. J Clin Psychiatry. 1979; 40: 348–351.
- 93 Shafik A. The role of the levator ani muscle in evacuation, sexual performance and pelvic floor disorders. Int Urogynecol J Pelvic Floor Dysfunct. 2000; 11: 361–376.
- 94 Puppo V. Embryology and anatomy of the vulva: the female orgasm and women's sexual health. Eur J Obstet Gynecol Reprod Biol. 2011; 154: 3–8.
- 95 Martinez CS, Ferreira FV, Castro AA, Gomide LB. Women with greater pelvic floor muscle strength have better sexual function. Acta Obstet Gynecol Scand. 2014; 93: 497–502.
- 96 Lowenstein L, Gruenwald I, Gartman I, Vardi Y. Can stronger pelvic muscle floor improve sexual function? Int Urogynecol J. 2010; 21: 553–556.
- 97 Rosenbaum TY, Owens A. The role of pelvic floor physical therapy in the treatment of pelvic and genital pain-related sexual dysfunction (CME). J Sex Med. 2008; 5: 513–523. quiz 524–5.
- 98 Morin M, Bergeron S, Khalife S, Mayrand MH, Binik YM. Morphometry of the pelvic floor muscles in women with and without provoked vestibulodynia using 4D ultrasound. J Sex Med. 2014; 11: 776–785.
- 99 Bo K, Sherburn M. Evaluation of female pelvic-floor muscle function and strength. Phys Ther. 2005; 85: 269–282.
- 100 Dumoulin C, Bourbonnais D, Lemieux MC. Development of a dynamometer for measuring the isometric force of the pelvic floor musculature. Neurourol Urodyn. 2003; 22: 648–653.
- 101 Morin M, Gravel D, Bourbonnais D, Dumoulin C, Ouellet S, Pilon JF. Application of a new method in the study of pelvic floor muscle passive properties in continent women. J Electromyogr Kinesiol. 2010; 20: 795–803.
- 102 Morin M, Gravel D, Bourbonnais D, Dumoulin C, Ouellet S. Reliability of dynamometric passive properties of the pelvic floor muscles in postmenopausal women with stress urinary incontinence. Neurourol Urodyn. 2008; 27: 819–825.
- 103 Dietz HP, Haylen BT, Broome J. Ultrasound Obstet Gynecol. 2001; 18: 511–514.
- 104 Beer-Gabel M, Teshler M, Barzilai N, et al. Dynamic transperineal ultrasound in the diagnosis of pelvic floor disorders: a pilot study. Dis Colon Rectum. 2002; 45: 239–245. Discussion 245-8.
- 105 Majida M, Braekken IH, Umek W, Bo K, Saltyte Benth J, Ellstrom Engh M. Interobserver repeatability of three- and four-dimensional transperineal ultrasound assessment of pelvic floor muscle anatomy and function. Ultrasound Obstet Gynecol. 2009; 33: 567–573.
- 106 Sandhu KS, Melman A, Mikhail MS. Impact of hormones on female sexual function and dysfunction. Female Pelvic Med Reconstr Surg. 2011; 17: 8–16.
- 107 Stuckey BG. Female sexual function and dysfunction in the reproductive years: the influence of endogenous and exogenous sex hormones. J Sex Med. 2008; 5: 2282–2290.
- 108 Jha S, Thaker R. Female sexual dysfunction. Eur J Obstetrics, Gynecol Reprod Biol. 2010; 153: 117–123.
- 109 Tuntiviriyapun P, Panyakhamlerd K, Triatamachat S, et al. Newly developed vaginal atrophy symptoms II and vaginal pH: a better correlation in vaginal atrophy? Climacteric. 2015; 18: 246–251.
- 110American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 5th edn. American Psychiatric Publishing, Danvers; 2013.
- 111 Sarin S, Amsel RM, Binik YM. Disentangling desire and arousal: a classificatory conundrum. Arch Sex Behav. 2013; 42: 1079–1100.
- 112 McCabe MP, Sharlip ID, Atalla E, et al. Definition of sexual dysfunction in women and men: a consensus statement from the fourth international consultation of sexual medicine. J Sex Med. 2015; 13: 135–143.
- 113 Portman DJ, Gass ML. Vulvovaginal atrophy terminology consensus conference panel. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the international society for the study of women's sexual health and the north american menopause society. Menopause. 2014; 21: 1063–1068.
- 114 Kingsberg SA, Woodward T. Female sexual dysfunction: focus on low desire. Obstet Gynecol. 2015; 125: 477–486.
- 115 Halis F, Yildirim P, Kocaaslan R, Cecen K, Gokce A. Pilates for better sex: changes in sexual functioning in healthy turkish women after pilates exercise. J Sex Marital Ther. 2015; 31: 1–7.
- 116 Aversa A, Bruzziches R, Francomano D, et al. Weight loss by multidisciplinary intervention improves endothelial and sexual function in obese fertile women. J Sex Med. 2013; 10: 1024–1033.
- 117 Pauls RN, Kleeman SD, Karram MM. Female sexual dysfunction: principles of diagnosis and therapy. Obstet Gynecol Surv. 2005; 60: 196–205.
- 118 Kalmbach DA, Arnedt JT, Pillai V, Ciesla JA. The impact of sleep on female sexual response and behavior: a pilot study. J Sex Med. 2015; 12: 1221–1232.
- 119 Farrell J, Cacchioni T. The medicalization of women's sexual pain. J Sex Res. 2012; 49: 328–336.
- 120 De Andres J, Sanchis-Lopez N, Asensio-Samper JM, et al. Vulvodynia-an evidence-based literature review and proposed treatment algorithm. Pain Pract. 2016; 16: 204–236.
- 121 O'Hare PG, 3rd, Hoffmann AR, Allen P, Gordon B, Salin L, Whitmore K. Interstitial cystitis patients' use and rating of complementary and alternative medicine therapies. Int Urogynecol J. 2013; 24: 977–982.
- 122 Wehbe SA, Fariello JY, Whitmore K. Minimally invasive therapies for chronic pelvic pain syndrome. Curr Urol Rep. 2010; 11: 276–185.
- 123 Balzer AM, Mintz LB. Comparing two books and establishing probably efficacious treatment for low sexual desire. J Couns Psychol. 2015; 62: 321–328.
- 124 Mintz LB, Balzer AM, Zhao X, Bush HE. Bibliotherapy for low sexual desire: evidence for effectiveness. J Couns Psychol. 2012; 59: 471–478.
- 125 Herbenick D, Reece M, Schick V, Sanders SA, Fortenberry JD. Women's use and perceptions of commercial lubricants: prevalence and characteristics ion a nationally representative sample of American adults. J Sex Med. 2014; 11: 642–652.
- 126 Sutton KS, Boyer SC, Goldfinger C, Ezer P, Pukall CF. To lube or not to lube: experiences and perceptions of lubricant use in women with and without dyspareunia. J Sex Med. 2012; 9: 240–250.
- 127 Goldstein I. Current management strategies of the postmenopausal patient with sexual health problems. J Sex Med. 2007; 4: 235–253.
- 128 Ferguson DM, Hosmane B, Heiman JR. Randomized, placebo-controlled, double-blind, parallel design trial of the efficacy and safety of zestra in women with mixed Desire/Interest/Arousal/Orgasm disorders. J Sex Marital Ther. 2010; 36: 66–86.
- 129 Ferguson DM, Steidle CP, Singh GS, Alexander JS, Weihmiller MK, Crosby MG. Randomized, placebo-controlled, double blind, crossover design trial of the efficacy and safety of zestra for women in women with and without female sexual arousal disorder. J Sex Marital Ther. 2003; 29: 33–44.
- 130 Donders GG, Bellen G. Cream with cutaneous fibroblast lysate for the treatment of provoked vestibulodynia: a double-blind randomized placebo-controlled crossover study. J Low Genit Tract Dis. 2012; 16: 427–436.
- 131 Islam A, Mitchel J, Rosen R, et al. Topical alprostadil in the treatment of female sexual arousal disorder: a pilot study. J Sex Marital Ther. 2001; 27: 531–540.
- 132 Kielbasa LA, Daniel KL. Topical alprostadil treatment of female sexual arousal disorder. Ann Pharmacother. 2006; 40: 1369–1376.
- 133 Belkin ZR, Krapf JM, Goldstein AT. Drugs in early clinical development for the treatment of female sexual dysfunction. Expert Opin Investig Drugs. 2015; 24: 159–167.
- 134 Kao A, Binik YM, Amsel R, Funaro D, Leroux N, Khalife S. Biopsychosocial predictors of postmenopausal dyspareunia: the role of steroid hormones, vulvovaginal atrophy, cognitive emotional factors, and dyadic adjustment. J Sex Med. 2012; 9: 2066–2076.
- 135 Brotto LA, Basson R, Luria M. A mindfulness-based group psychoeducational intervention targeting sexual arousal disorder in women. J Sex Med. 2008; 5: 1646–1659.
- 136 Brotto LA, Erskine Y, Carey M, et al. A brief mindfulness-based cognitive behavioral intervention improves sexual functioning versus wait-list control in women treated for gynecologic cancer. Gynecol Oncol. 2012; 125: 320–325.
- 137 Billups KL. The role of mechanical devices in treating female sexual dysfunction and enhancing the female sexual response. World J Urol. 2002; 20: 137–141.
- 138 Billups KL, Berman L, Berman J, Metz ME, Glennon ME, Goldstein I. A new non-pharmacological vacuum therapy for female sexual dysfunction. J Sex Marital Ther. 2001; 27: 435–441.
- 139 Bakker RM, Ter Kuile MM, Vermeer WM, et al. Sexual rehabilitation after pelvic radiotherapy and vaginal dilator use: consensus using the delphi method. Int J Gynecol Cancer. 2014; 24: 1499–1506.
- 140 Miles T, Johnson N. Vaginal dilator therapy for women receiving pelvic radiotherapy. Cochrane Database Syst Rev. 2014; 9: CD007291.
- 141 Antosh DD, Gutman RE, Park AJ, et al. Vaginal dilators for prevention of dyspareunia after prolapse surgery: a randomized controlled trial. Obstet Gynecol. 2013; 121: 1273–1280.
- 142 Idama TO, Pring DW. Vaginal dilator therapy- an outpatient gynaecological option in the management of dyspareunia. J Obstet Gynaecol. 2000; 20: 303–305.
- 143 Herbenick D, Reece M, Sanders S, Dodge B, Ghassemi A, Fortenberry JD. Prevalence and characteristics of vibrator use by women in the United States: results from a nationally representative study. J Sex Med. 2009; 6: 1857–1866.
- 144 Herbenick D, Reece M, Schick V, et al. Beliefs about women's vibrator use: results from a nationally representative probability survey in the United States. J Sex Marital Ther. 2011; 37: 329–345.
- 145 Klapilova K, Brody S, Krejcova L, Husarova B, Binter J. Sexual satisfaction, sexual compatibility, and relationship adjustment in couples: the role of sexual behaviors, orgasm, and men's discernment of women's intercourse orgasm. J Sex Med. 2015; 12: 667–675.
- 146 Zerbinati N, Serati M, Origoni M, et al. Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment. Lasers Med Sci. 2015; 30: 429–436.
- 147 Salvatore S, Nappi RE, Parma M, et al. Sexual function after fractional microablative CO2 Laser in women with vulvovaginal atrophy. Climacteric. 2015; 18: 219–225.
- 148 Hutchinson-Colas J, Segal S. Genitourinary syndrome of menopause and the use of laser therapy. Maturitas. 2015; 82: 342–345.
- 149 Perino A, Calligaro A, Forlani F, et al. Vulvo-vaginal atrophy: a new treatment modality using thermo-ablative fractional CO2 laser. Maturitas. 2015; 80: 296–301.
- 150 Salvatore S, Nappi RE, Zerbinati N, et al. A 12-week treatment with fractional CO2 laser for vulvovaginal atrophy: a pilot study. Climacteric. 2014; 17: 363–369.
- 151 Schlaeger JM, Xu N, Mejta CL, Park CG, Wilkie DJ. Acupuncture for the treatment of vulvodynia: a randomized wait-list controlled pilot study. J Sex Med. 2015; 12: 1019–1027.
- 152
Oakley S,
Walther-Liu J,
Crisp CC,
Pauls RN. Acupuncture in premenopausal women with hypoactive sexual desire disorder: a prospective cohort study.
J Minimal Invasive Gynecol.
2015;
22: S37–S38.
10.1016/j.jmig.2014.12.078 Google Scholar
- 153 Dumoulin C, Hay-Smith EJ, Mac Habee-Sequin G. Pelvic floor muscle training versus treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev. 2014; 5: CD005654.
- 154 Sacomori C, Cardoso FL. Predictors of improvement in sexual function of women with urinary incontinence after treatment with pelvic floor exercises: a secondary analysis. J Sex Med. 2015; 12: 746–755.
- 155 Gentilcore-Saulnier E, McLean L, Goldfinger C, Pukall CF, Chamberlain S. Pelvic floor muscle assessment outcomes in women with and without provoked vestibulodynia and the impact of a physical therapy program. J Sex Med. 2010; 7: 1003–1022.
- 156 Kamanli A, Kaya A, Ardicoglu O, et al. Comparison of lidocaine injection, botulinum toxin injection, and dry needling to trigger points in myofascial pain syndrome. Rheumatol Int. 2005; 25: 604–611.
- 157 Zoorob D, South M, Karram M, et al. A pilot randomized trial of levator injections versus physical therapy for treatment of pelvic floor myalgia and sexual pain. Int Urogynecol J. 2015; 26: 845–852.
- 158 Morrissey D, El-khawand D, Ginzburg N, Wehbe S, O”Hare P, 3rd, Whitmore K. Botulinum toxin A injections into pelvic floor muscles under electromyographic guidance for women with refractory high-tone pelvic floor dysfunction: a 6 month prospective pilot study. Female Pelvic Med Reconstr Surg. 2015; 21: 277–282.
- 159 Modelska K, Cummings S. Female sexual dysfunction in postmenopausal women: systematic review of placebo-controlled trials. Am J Obstet Gynecol. 2003; 188: 286–293.
- 160 Hammett J, Peters A, Trowbridge E, Hullfish K. Short-term surgical outcomes and characteristics of patients with mesh complications from pelvic organ prolapse and stress urinary incontinence surgery. Int Urogynecol J. 2014; 25: 465–470.
- 161 Wurz GT, Kao CJ, DeGregorio MW. Safety and efficacy of ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy due to menopause. Clin Interv Aging. 2014; 9: 1939–1950.
- 162 Constantine GD, Goldstein SR, Archer DF. Endometrial safety of ospemifene: results of the phase 2/3 clinical development program. Menopause. 2015; 22: 36–43.
- 163 Constantine G, Graham S, Portman DJ, Rosen RC, Kingsberg SA. Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy: results of a randomized, placebo-controlled trial. Climacteric. 2015; 18: 226–232.
- 164 Labrie F, Archer DF, Martel C, Vaillancourt M, Montesino M. Combined data of intravaginal prasterone against vulvovaginal atrophy of menopause. Menopause. 2017; 24: 1246–1256.
- 165 Safarinejad MR. Evaluation of the safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study. J Sex Med. 2008; 5: 887–897.
- 166 Simon JA, Kingsberg SA, Shumel B, Hanes V, Garcia M, Jr, Sand M. Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder: results of the SNOWDROP trial. Menopause. 2014; 21: 633–640.
- 167 Katz M, DeRogatis LR, Ackerman R, et al. Efficacy of flibanserin in women with hypoactive sexual desire disorder: results from the BEGONIA trial. J Sex Med. 2013; 10: 1807–1815.
- 168 Poels S, Bloemers J, van Rooij K, et al. Toward personalized sexual medicine (part 2): testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues. J Sex Med. 2013; 10: 810–823.
- 169 Perelman MA. The sexual tipping point: a mind/body model for sexual medicine. J Sex Med. 2009; 6: 629–632.
- 170 Van Rooij K, Poels S, Bloemers J, et al. Toward personalized sexual medicine (part 3): testosterone combined with a Serotonin1A receptor agonist increases sexual satisfaction in women with HSDD and FSAD, and dysfunctional activation of sexual inhibitory mechanisms. J Sex Med. 2013; 10: 824–837.
- 171 Bloemers J, van Rooij K, Poels S, et al. Toward personalized sexual medicine (Part 1): integrating the “Dual control model” into differential drug treatments for hypoactive sexual desire disorder and female sexual arousal disorder. J Sex Med. 2013; 10: 791–809.
- 172 Bechara A, Bertolino MV, Casabe A, Fredotovich N. A double-blind randomized placebo control study comparing the objective and subjective changes in female sexual response using sublingual apomorphine. J Sex Med. 2004; 1: 209–214.
- 173 Segraves RT, Croft H, Kavoussi R, et al. Bupropion sustained release (SR) for the treatment of hypoactive sexual desire disorder (HSDD) in nondepressed women. J Sex Marital Ther. 2001; 27: 303–316.
- 174 Pauls RN, Marinkovic SP, Silva WA, Rooney CM, Kleeman SD, Karram MM. Effects of sacral neuromodulation on female sexual function. Int Urogynecol J Pelvic Floor Dysfunct. 2007; 18: 391–395.
- 175 Urwitz-Lane T, Ozel B. Sexual function in women with urodynamic stress incontinence, detrusor overactivity, and mixed urinary incontinence. Am J Obstet Gynecol. 2006; 195: 1758–1761.
- 176 Rogers RG, Kammerer-Doak D, Darrow A, et al. Does sexual function change after surgery for stress urinary incontinence and/or pelvic organ prolapse? A multicenter prospective study. Am J Obstet Gynecol. 2006; 195: e1–e4.
- 177 Lukacz ES, Warren LK, Richter HE, et al. Quality of life and sexual function 2 years after vaginal surgery for prolapse. Obstet Gynecol. 2016; 127: 1071–1079.
- 178 Clavien PA, Barkun J, de Oliveira ML. The clavien-dindo classification of surgical complications: 5 years’ experience. Ann Surg. 2009; 250: 187–196.
- 179 Haylen BT, Freeman RM, Lee J, et al. An international urogynecological association (IUGA)/International continence society (ICS) joint terminology and classification of the complications related to native tissue female pelvic floor surgery. Int Urogynecol J. 2012; 23: 515–526.
- 180 McCabe MP, Sharlip ID, Atalla E, et al. Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J Sex Med. 2016; 13: 135–143.
- 181 Parish SJ, Goldstein AT, Goldstein SW, et al. Toward a more evidence-Based nosology and nomenclature for female sexual dysfunctions-Part II. J Sex Med. 2016; 13: 1888–1906.