Vasculitic neuropathy in a patient with cryoglobulinemia and anti-MAG IGM monoclonal gammopathy
Corresponding Author
Dr. Florian P. Thomas MD
Department of Pathology, Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York, New York
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada, H2W 1R7Search for more papers by this authorDr. Robert E. Lovelace MD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Xin-Sheng Ding MD
Department of Pathology, Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Saud A. Sadiq MD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. George W. Petty MD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. William H. Sherman MD
Department of Internal Medicine, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Norman Latov MD, PhD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Arthur P. Hays MD
Department of Pathology, Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorCorresponding Author
Dr. Florian P. Thomas MD
Department of Pathology, Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York, New York
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada, H2W 1R7Search for more papers by this authorDr. Robert E. Lovelace MD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Xin-Sheng Ding MD
Department of Pathology, Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Saud A. Sadiq MD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. George W. Petty MD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. William H. Sherman MD
Department of Internal Medicine, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Norman Latov MD, PhD
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorDr. Arthur P. Hays MD
Department of Pathology, Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York, New York
Search for more papers by this authorAbstract
A patient with sensorimotor mononeuritis multiplex had a type II cryoglobulin with an IgM kappa M-protein that appeared to contain monoclonal anti-MAG antibodies of the same isotype. A sural nerve biopsy demonstrated necrotizing arteritis and features of both axonal degeneration and demyelination. IgM kappa and C3 deposits were present on the myelin sheath of some residual nerve fibers. The findings suggest that the anti-MAG antibodies contributed to the myelin damage, while cryoprecipitates may have caused the vasculitis and axonal degeneration. © 1992 John Wiley & Sons, Inc.
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