Reply to “Intravenous saline may not be a placebo in patients with small fiber neuropathy”
Corresponding Author
Christopher H. Gibbons MD
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Correspondence
Christopher H. Gibbons, Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA.
Email: [email protected]
Contribution: Writing - original draft, Writing - review & editing
Search for more papers by this authorSharika Rajan MD
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorKatherine Senechal BA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorErin Hendry BA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorBrady McCallister BA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorTodd D. Levine MD
Honorhealth Neurology, Phoenix, Arizona, USA
Contribution: Writing - review & editing
Search for more papers by this authorCorresponding Author
Christopher H. Gibbons MD
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Correspondence
Christopher H. Gibbons, Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA.
Email: [email protected]
Contribution: Writing - original draft, Writing - review & editing
Search for more papers by this authorSharika Rajan MD
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorKatherine Senechal BA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorErin Hendry BA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorBrady McCallister BA
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Contribution: Writing - review & editing
Search for more papers by this authorTodd D. Levine MD
Honorhealth Neurology, Phoenix, Arizona, USA
Contribution: Writing - review & editing
Search for more papers by this authorCONFLICT OF INTEREST STATEMENT
C.H.G. and T.D.L. have received institutional research support from Grifols to conduct this study. The remaining authors declare no potential conflicts of interest.
REFERENCES
- 1Hrobjartsson A, Gotzsche PC. Placebo interventions for all clinical conditions. Cochrane Database Syst Rev. 2010; 2010:CD003974.
- 2Kaptchuk TJ, Hemond CC, Miller FG. Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice. BMJ. 2020; 370:m1668.
- 3Williams EL, Raj SR, Schondorf R, Shen WK, Wieling W, Claydon VE. Salt supplementation in the management of orthostatic intolerance: vasovagal syncope and postural orthostatic tachycardia syndrome. Auton Neurosci. 2022; 237:102906.
- 4Ruzieh M, Baugh A, Dasa O, et al. Effects of intermittent intravenous saline infusions in patients with medication-refractory postural tachycardia syndrome. J Interv Card Electrophysiol. 2017; 48: 255-260.
- 5Trevino JA, Novak P. TS-HDS and FGFR3 antibodies in small fiber neuropathy and dysautonomia. Muscle Nerve. 2021; 64: 70-76.
- 6Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010; 68: 888-898.
- 7Singleton JR, Marcus RL, Lessard MK, Jackson JE, Smith AG. Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients. Ann Neurol. 2015; 77: 146-153.