Effect of constitutive inactivation of the myostatin gene on the gain in muscle strength during postnatal growth in two murine models
Amalia Stantzou PhD
Université de Versailles Saint-Quentin, Unité de formation et de recherche des sciences de la santé des sciences, Montigny-le-Bretonneux, France
Search for more papers by this authorVanessa Ueberschlag-Pitiot PhD
Université de Strasbourg, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
Search for more papers by this authorRemi Thomasson PhD
Université Paris Descartes, Institut de Recherche bio-Médicale et d'Epidémiologie du Sport, Sorbonne Paris Cité, Paris, France
Search for more papers by this authorDenis Furling PhD
Sorbonne Universités CNRS, Centre de Recherche en Myologie, Paris, France
Search for more papers by this authorAnne Bonnieu PhD
INRA, Université Montpellier, Dynamique Musculaire et Métabolisme, Montpellier, France
Search for more papers by this authorHelge Amthor PhD
Université de Versailles Saint-Quentin, Unité de formation et de recherche des sciences de la santé des sciences, Montigny-le-Bretonneux, France
Search for more papers by this authorCorresponding Author
Arnaud Ferry PhD
Sorbonne Universités CNRS, Centre de Recherche en Myologie, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Correspondence to: A. Ferry; G.H. Pitié-Salpétrière, 47, bld de l'Hôpital, Bâtiment Babinski, Centre de Recherche en myoLogie, 75651 Paris cedex 13, France. e-mail: [email protected]Search for more papers by this authorAmalia Stantzou PhD
Université de Versailles Saint-Quentin, Unité de formation et de recherche des sciences de la santé des sciences, Montigny-le-Bretonneux, France
Search for more papers by this authorVanessa Ueberschlag-Pitiot PhD
Université de Strasbourg, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
Search for more papers by this authorRemi Thomasson PhD
Université Paris Descartes, Institut de Recherche bio-Médicale et d'Epidémiologie du Sport, Sorbonne Paris Cité, Paris, France
Search for more papers by this authorDenis Furling PhD
Sorbonne Universités CNRS, Centre de Recherche en Myologie, Paris, France
Search for more papers by this authorAnne Bonnieu PhD
INRA, Université Montpellier, Dynamique Musculaire et Métabolisme, Montpellier, France
Search for more papers by this authorHelge Amthor PhD
Université de Versailles Saint-Quentin, Unité de formation et de recherche des sciences de la santé des sciences, Montigny-le-Bretonneux, France
Search for more papers by this authorCorresponding Author
Arnaud Ferry PhD
Sorbonne Universités CNRS, Centre de Recherche en Myologie, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Correspondence to: A. Ferry; G.H. Pitié-Salpétrière, 47, bld de l'Hôpital, Bâtiment Babinski, Centre de Recherche en myoLogie, 75651 Paris cedex 13, France. e-mail: [email protected]Search for more papers by this authorABSTRACT
Introduction: The effect of constitutive inactivation of the gene encoding myostatin on the gain in muscle performance during postnatal growth has not been well characterized. Methods: We analyzed 2 murine myostatin knockout (KO) models, (i) the Lee model (KOLee) and (ii) the Grobet model (KOGrobet), and measured the contraction of tibialis anterior muscle in situ. Results: Absolute maximal isometric force was increased in 6-month-old KOLee and KOGrobet mice, as compared to wild-type mice. Similarly, absolute maximal power was increased in 6-month-old KOLee mice. In contrast, specific maximal force (relative maximal force per unit of muscle mass was decreased in all 6-month-old male and female KO mice, except in 6-month-old female KOGrobet mice, whereas specific maximal power was reduced only in male KOLee mice. Conclusions: Genetic inactivation of myostatin increases maximal force and power, but in return it reduces muscle quality, particularly in male mice. Muscle Nerve 55: 254–261, 2017
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