Short Reports

Flaviviruses in motor neuron disease

Corresponding Author

Roger Pamphlett MD

[email protected]

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, AustraliaSearch for more papers by this author

Stephen Kum-Jew,

Stephen Kum-Jew

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

Search for more papers by this author

Nicholas J. C. King PhD, MB, ChB,

Nicholas J. C. King PhD, MB, ChB

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

Search for more papers by this author

Roger Pamphlett MD,

Corresponding Author

Roger Pamphlett MD

[email protected]

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, AustraliaSearch for more papers by this author

Stephen Kum-Jew,

Stephen Kum-Jew

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

Search for more papers by this author

Nicholas J. C. King PhD, MB, ChB,

Nicholas J. C. King PhD, MB, ChB

Department of Pathology, D06, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

Search for more papers by this author

First published: 18 March 2005

https://doi.org/10.1002/mus.20320

Citations: 3

Share a link

Email
Wechat
Bluesky

Abstract

Sporadic motor neuron disease (MND) causes a progressive loss of motor neurons. West Nile virus can attack motor neurons, so we examined whether flavivirus infection could be detected in MND cases. Spinal cord sections from 22 MND cases were stained immunohistochemically with a flavivirus-specific antibody. No staining for flavivirus was seen in any case. Sporadic MND does not appear to arise from a recent infection with a flavivirus. Muscle Nerve, 2005

REFERENCES

1 Arnold SJ, Osvath SR, Hall RA, King NJ, Sedger LM. Regulation of antigen processing and presentation molecules in West Nile virus-infected human skin fibroblasts. Virology 2004; 324: 286–296.
10.1016/j.virol.2004.03.036
CAS PubMed Web of Science® Google Scholar
2 Berger MM, Kopp N, Vital C, Redl B, Aymard M, Lina B. Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS. Neurology 2000; 54: 20–25.
10.1212/WNL.54.1.20
CAS PubMed Web of Science® Google Scholar
3 Besselaar TG, Blackburn NK. Antigenic analysis of West Nile virus strains using monoclonal antibodies. Arch Virol 1988; 99: 75–88.
10.1007/BF01311025
CAS PubMed Web of Science® Google Scholar
4 Bodian D. Poliomyelitis. Neuropathologic observations in relation to motor symptoms. JAMA 1947; 134: 1148–1154.
10.1001/jama.1947.02880310006002
CAS PubMed Web of Science® Google Scholar
5 Fratkin JD, Leis AA, Stokic DS, Slavinski SA, Geiss RW. Spinal cord neuropathology in human West Nile virus infection. Arch Pathol Lab Med 2004; 128: 533–537.
PubMed Web of Science® Google Scholar
6 Gadoth N, Weitzman S, Lehmann EE. Acute anterior myelitis complicating West Nile fever. Arch Neurol 1979; 36: 172–173.
10.1001/archneur.1979.00500390090012
CAS PubMed Web of Science® Google Scholar
7 Giraud P, Beaulieux F, Ono S, Shimizu N, Chazot G, Lina B. Detection of enteroviral sequences from frozen spinal cord samples of Japanese ALS patients. Neurology 2001; 56: 1777–1778.
10.1212/WNL.56.12.1777
CAS PubMed Web of Science® Google Scholar
8 Glass JD, Samuels O, Rich MM. Poliomyelitis due to West Nile virus. N Engl J Med 2002; 347: 1280–1281.
10.1056/NEJM200210173471616
PubMed Web of Science® Google Scholar
9 Guarner J, Shieh WJ, Hunter S, Paddock CD, Morken T, Campbell GL, et al. Clinicopathologic study and laboratory diagnosis of 23 cases with West Nile virus encephalomyelitis. Hum Pathol 2004; 35: 983–990.
10.1016/j.humpath.2004.04.008
PubMed Web of Science® Google Scholar
10 Leis AA, Stokic DS, Polk JL, Dostrow V, Winkelmann M. A poliomyelitis-like syndrome from West Nile virus infection. N Engl J Med 2002; 347: 1279–1280.
10.1056/NEJM2002c021587
PubMed Web of Science® Google Scholar
11 Nix WA, Berger MM, Oberste MS, Brooks BR, McKenna-Yasek DM, Brown RH Jr, et al. Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method. Neurology 2004; 62: 1372–1377.
10.1212/01.WNL.0000123258.86752.51
CAS PubMed Web of Science® Google Scholar
12 Rice S, Pamphlett R. Study linking enteroviral infection with motor neurone disease is not confirmed. Br Med J 1997; 315: 1380.
10.1136/bmj.315.7119.1380
CAS PubMed Web of Science® Google Scholar
13 Saunderson R, Yu B, Trent RJ, Pamphlett R. A polymorphism in the poliovirus receptor gene differs in motor neuron disease. Neuroreport 2004; 15: 383–386.
10.1097/00001756-200402090-00034
PubMed Web of Science® Google Scholar
14 Shaw PJ. Motor neurone disease. Br Med J 1999; 318: 1118–1121.
10.1136/bmj.318.7191.1118
CAS PubMed Web of Science® Google Scholar
15 Walker MP, Schlaberg R, Hays AP, Bowser R, Lipkin WI. Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients. Ann Neurol 2001; 49: 249–253.
10.1002/1531-8249(20010201)49:2<249::AID-ANA46>3.0.CO;2-3
CAS PubMed Web of Science® Google Scholar
16 Woodall CJ, Riding MH, Graham DJ, Clements GB. Sequences specific for enterovirus detected in spinal cord from patients with motor neurone disease. Br Med J 1994; 308: 1541–1543.
10.1136/bmj.308.6943.1541
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume32, Issue1

July 2005

Pages 108-109

Flaviviruses in motor neuron disease

Abstract

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Flaviviruses in motor neuron disease

Abstract

REFERENCES

Citing Literature

References

Related

Information