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Blood γδ T cells, Campylobacter jejuni, and GM1 titers in Guillain–Barré syndrome
Stephen N. Scelsa MD,
Violette Ghali MD,
Steven Herskovitz MD,
Phyllis Bieri MD,
Deborah L. Shank MS,
Daniel D. J. MacGowan MD,
Sally Liau MS,
Corresponding Author
Stephen N. Scelsa MD
Department of Neurology, Beth Israel Medical Center, New York, New York, USA
Albert Einstein College of Medicine, Bronx, New York, USA
Beth Israel Medical Center, Phillips Ambulatory Care Center, 10 Union Square, Suite 2Q, New York, New York 10003Search for more papers by this authorViolette Ghali MD
Department of Immunology, Beth Israel Medical Center, New York, New York, USA
Search for more papers by this authorSteven Herskovitz MD
Department of Neurology, Montefiore Medical Center, Bronx, New York, USA
Search for more papers by this authorPhyllis Bieri MD
Department of Neurology, Montefiore Medical Center, Bronx, New York, USA
Search for more papers by this authorDeborah L. Shank MS
Department of Immunology, Beth Israel Medical Center, New York, New York, USA
Search for more papers by this authorDaniel D. J. MacGowan MD
Department of Neurology, Beth Israel Medical Center, New York, New York, USA
Albert Einstein College of Medicine, Bronx, New York, USA
Search for more papers by this authorSally Liau MS
Department of Immunology, Beth Israel Medical Center, New York, New York, USA
Search for more papers by this authorStephen N. Scelsa MD,
Violette Ghali MD,
Steven Herskovitz MD,
Phyllis Bieri MD,
Deborah L. Shank MS,
Daniel D. J. MacGowan MD,
Sally Liau MS,
Corresponding Author
Stephen N. Scelsa MD
Department of Neurology, Beth Israel Medical Center, New York, New York, USA
Albert Einstein College of Medicine, Bronx, New York, USA
Beth Israel Medical Center, Phillips Ambulatory Care Center, 10 Union Square, Suite 2Q, New York, New York 10003Search for more papers by this authorViolette Ghali MD
Department of Immunology, Beth Israel Medical Center, New York, New York, USA
Search for more papers by this authorSteven Herskovitz MD
Department of Neurology, Montefiore Medical Center, Bronx, New York, USA
Search for more papers by this authorPhyllis Bieri MD
Department of Neurology, Montefiore Medical Center, Bronx, New York, USA
Search for more papers by this authorDeborah L. Shank MS
Department of Immunology, Beth Israel Medical Center, New York, New York, USA
Search for more papers by this authorDaniel D. J. MacGowan MD
Department of Neurology, Beth Israel Medical Center, New York, New York, USA
Albert Einstein College of Medicine, Bronx, New York, USA
Search for more papers by this authorSally Liau MS
Department of Immunology, Beth Israel Medical Center, New York, New York, USA
Search for more papers by this authorAbstract
The γδ T cells participate in microbial defense, are prevalent in intestinal epithelia, and are activated in autoimmune diseases. We studied whether peripheral blood γδ cells and γδ subsets are increased in Guillain–Barré syndrome (GBS) and whether elevations are associated with Campylobacter jejuni infection or GM1 elevations. In 20 GBS patients, we performed serial flow cytometry studies of blood γδ, Vδ1, and Vδ2 cells (±CD8+), C jejuni, and ganglioside titers. There was no significant difference in median γδ T-cell percentages between GBS patients and controls at onset and at convalescence. However, 5 patients had marked Vδ1/CD8+ elevations. Elevated Vδ1 or Vδ1/CD8+ cells occurred in 3 of 6 patients with C jejuni or GM1 titer elevations. A minority of GBS patients have elevations of Vδ1/CD8+ cells, possibly associated with elevated C jejuni or GM1 titers. The γδ T cells may have a cytotoxic (or suppressor) role in the disease. Muscle Nerve 30: 423–432, 2004
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