inhomogeneity correction of volumetric brain NOEMTR via high permittivity dielectric padding at 7 T
Paul S. Jacobs
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorBlake Benyard
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorQuy Cao
Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorAnshuman Swain
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorNeil Wilson
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorRavi Prakash Reddy Nanga
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorM. Dylan Tisdall
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorJohn Detre
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMark A. Elliott
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMohammad Haris
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorCorresponding Author
Ravinder Reddy
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Correspondence
Ravinder Reddy, Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Email: [email protected]
Search for more papers by this authorPaul S. Jacobs
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorBlake Benyard
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorQuy Cao
Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorAnshuman Swain
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorNeil Wilson
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorRavi Prakash Reddy Nanga
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorM. Dylan Tisdall
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorJohn Detre
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMark A. Elliott
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMohammad Haris
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorCorresponding Author
Ravinder Reddy
Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Correspondence
Ravinder Reddy, Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Purpose
Nuclear Overhauser effect magnetization transfer ratio (NOEMTR) is a technique used to investigate brain lipids and macromolecules in greater detail than other techniques and benefits from increased contrast at 7 T. However, this contrast can become degraded because of inhomogeneities present at ultra-high field strengths. High-permittivity dielectric pads (DP) have been used to correct for these inhomogeneities via displacement currents generating secondary magnetic fields. The purpose of this work is to demonstrate that dielectric pads can be used to mitigate inhomogeneities and improve NOEMTR contrast in the temporal lobes at 7 T.
Methods
Partial 3D NOEMTR contrast images and whole brain field maps were acquired on a 7 T MRI across six healthy subjects. Calcium titanate DP, having a relative permittivity of 110, was placed next to the subject's head near the temporal lobes. Pad corrected NOEMTR images had a separate postprocessing linear correction applied.
Results
DP provided supplemental to the temporal lobes while also reducing the magnitude across the posterior and superior regions of the brain. This resulted in a statistically significant increase in NOEMTR contrast in substructures of the temporal lobes both with and without linear correction. The padding also produced a convergence in NOEMTR contrast toward approximately equal mean values.
Conclusion
NOEMTR images showed significant improvement in temporal lobe contrast when DP were used, which resulted from an increase in homogeneity across the entire brain slab. DP-derived improvements in NOEMTR are expected to increase the robustness of the brain substructural measures both in healthy and pathological conditions.
Supporting Information
Filename | Description |
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mrm29739-sup-0001-Figures.docxWord 2007 document , 2.7 MB | Figure S1. Histogram distributions of NOEMTR contrast value without linear correction (A), NOEMTR contrast values with linear correction (B), and relative strength (C) concatenated across all six subjects. Distribution narrowing can be seen in all data acquired with pads, reflecting an increase in homogeneity of maps and contrast in resulting NOEMTR images. It should be noted that histograms show data across the entire 3D slab of each subject dataset, with the first and last slices being omitted. Figure S2. Illustration of segmented subcortical regions viewed in orthogonal space. The subcortical regions that can be seen are left hippocampus (yellow), right hippocampus (light green), left amygdala (light blue), right amygdala (dark blue), left thalamus (dark green), and right thalamus (pink). Figure S3. Histogram comparisons for NOEMTR brain segmentations showing distribution narrowing and shifting when pads were used versus absent, reflecting an increase in contrast and homogenization on a regional level. Data in these histograms acquired across all slices from all subjects where the corresponding segmentations were present. Figure S4. Volumetric representation of maps acquired without (A) and with (B) dielectric pads. A volume rendering of the difference values across the whole brain (C) showing the increase is localized to the temporal lobes while the decrease is present across the posterior of the brain and majority of superior slices. It should be noted that difference values close to 0 were filtered out of the image to show the larger numeric differences more clearly. An MPRAGE acquisition across the same whole brain volume can be seen (D) as an anatomic reference. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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