Note
Regional effects of magnetization dispersion on quantitative perfusion imaging for pulsed and continuous arterial spin labeling
Mustafa Çavuşoğlu,
Rolf Pohmann,
Harold Christopher Burger,
Kâmil Uludağ,
Corresponding Author
Mustafa Çavuşoğlu
Max-Planck Institute for Biological Cybernetics, High Field Magnetic Resonance Center, Tübingen, Germany
Faculty of Mathematics and Physics, Universität Tübingen, Tübingen, Germany
Max-Planck Institute for Biological Cybernetics, Spemannstr 41, 72076 Tübingen, Germany===Search for more papers by this authorRolf Pohmann
Max-Planck Institute for Biological Cybernetics, High Field Magnetic Resonance Center, Tübingen, Germany
Search for more papers by this authorHarold Christopher Burger
Max-Planck Institute for Biological Cybernetics, Empirical Inference Center, Tübingen, Germany
Search for more papers by this authorKâmil Uludağ
Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
Search for more papers by this authorMustafa Çavuşoğlu,
Rolf Pohmann,
Harold Christopher Burger,
Kâmil Uludağ,
Corresponding Author
Mustafa Çavuşoğlu
Max-Planck Institute for Biological Cybernetics, High Field Magnetic Resonance Center, Tübingen, Germany
Faculty of Mathematics and Physics, Universität Tübingen, Tübingen, Germany
Max-Planck Institute for Biological Cybernetics, Spemannstr 41, 72076 Tübingen, Germany===Search for more papers by this authorRolf Pohmann
Max-Planck Institute for Biological Cybernetics, High Field Magnetic Resonance Center, Tübingen, Germany
Search for more papers by this authorHarold Christopher Burger
Max-Planck Institute for Biological Cybernetics, Empirical Inference Center, Tübingen, Germany
Search for more papers by this authorKâmil Uludağ
Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
Search for more papers by this authorAbstract
Most experiments assume a global transit delay time with blood flowing from the tagging region to the imaging slice in plug flow without any dispersion of the magnetization. However, because of cardiac pulsation, nonuniform cross-sectional flow profile, and complex vessel networks, the transit delay time is not a single value but follows a distribution. In this study, we explored the regional effects of magnetization dispersion on quantitative perfusion imaging for varying transit times within a very large interval from the direct comparison of pulsed, pseudo-continuous, and dual-coil continuous arterial spin labeling encoding schemes. Longer distances between tagging and imaging region typically used for continuous tagging schemes enhance the regional bias on the quantitative cerebral blood flow measurement causing an underestimation up to 37% when plug flow is assumed as in the standard model. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
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