Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI
Corresponding Author
Niranjan Balu
Department of Radiology, University of Washington, Seattle, Washington, USA
Vascular Imaging Laboratory, 815, Mercer Street, Box 358050, Seattle, Washington 98019===Search for more papers by this authorVasily L. Yarnykh
Department of Radiology, University of Washington, Seattle, Washington, USA
Search for more papers by this authorBaocheng Chu
Department of Radiology, University of Washington, Seattle, Washington, USA
Search for more papers by this authorJinnan Wang
Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, New York, USA
Search for more papers by this authorThomas Hatsukami
Department of Surgery, University of Washington, Seattle, Washington, USA
Search for more papers by this authorChun Yuan
Department of Radiology, University of Washington, Seattle, Washington, USA
Search for more papers by this authorCorresponding Author
Niranjan Balu
Department of Radiology, University of Washington, Seattle, Washington, USA
Vascular Imaging Laboratory, 815, Mercer Street, Box 358050, Seattle, Washington 98019===Search for more papers by this authorVasily L. Yarnykh
Department of Radiology, University of Washington, Seattle, Washington, USA
Search for more papers by this authorBaocheng Chu
Department of Radiology, University of Washington, Seattle, Washington, USA
Search for more papers by this authorJinnan Wang
Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, New York, USA
Search for more papers by this authorThomas Hatsukami
Department of Surgery, University of Washington, Seattle, Washington, USA
Search for more papers by this authorChun Yuan
Department of Radiology, University of Washington, Seattle, Washington, USA
Search for more papers by this authorAbstract
Black-blood MRI is a promising tool for carotid atherosclerotic plaque burden assessment and compositional analysis. However, current sequences are limited by large slice thickness. Accuracy of measurement can be improved by moving to isotropic imaging but can be challenging for patient compliance due to long scan times. We present a fast isotropic high spatial resolution (0.7 × 0.7 × 0.7 mm3) three-dimensional black-blood sequence (3D-MERGE) covering the entire cervical carotid arteries within 2 min thus ensuring patient compliance and diagnostic image quality. The sequence is optimized for vessel wall imaging of the carotid bifurcation based on its signal properties. The optimized sequence is validated on patients with significant carotid plaque. Quantitative plaque morphology measurements and signal-to-noise ratio measures show that 3D-MERGE provides good blood suppression and comparable plaque burden measurements to existing MRI protocols. 3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque. Magn Reson Med, 2011. © 2010 Wiley-Liss, Inc.
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