In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: Application of high-resolution inner-volume black blood 3D FSE
Corresponding Author
Dimitris Mitsouras
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115===Search for more papers by this authorChristopher D. Owens
Harvard Medical School, Boston, Massachusetts
Division of Vascular Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts
Search for more papers by this authorMichael S. Conte
Harvard Medical School, Boston, Massachusetts
Division of Vascular Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts
Search for more papers by this authorHale Ersoy
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Search for more papers by this authorMark A. Creager
Harvard Medical School, Boston, Massachusetts
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
Search for more papers by this authorFrank J. Rybicki
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Search for more papers by this authorRobert V. Mulkern
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Department of Radiology, Children's Hospital, Boston, Massachusetts
Search for more papers by this authorCorresponding Author
Dimitris Mitsouras
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115===Search for more papers by this authorChristopher D. Owens
Harvard Medical School, Boston, Massachusetts
Division of Vascular Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts
Search for more papers by this authorMichael S. Conte
Harvard Medical School, Boston, Massachusetts
Division of Vascular Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts
Search for more papers by this authorHale Ersoy
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Search for more papers by this authorMark A. Creager
Harvard Medical School, Boston, Massachusetts
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts
Search for more papers by this authorFrank J. Rybicki
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Search for more papers by this authorRobert V. Mulkern
Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Medical School, Boston, Massachusetts
Department of Radiology, Children's Hospital, Boston, Massachusetts
Search for more papers by this authorAbstract
Lower extremity peripheral vein bypass grafts (LE-PVBG) imaged with high-resolution black blood three-dimensional (3D) inner-volume (IV) fast spin echo (FSE) MRI at 1.5 Tesla possess a two-layer appearance in T1W images while only the inner layer appears visible in the corresponding T2W images. This study quantifies this difference in six patients imaged 6 months after implantation, and attributes the difference to the T2 relaxation rates of vessel wall tissues measured ex vivo in two specimens with histologic correlation. The visual observation of two LE-PVBG vessel wall components imaged in vivo is confirmed to be significant (P < 0.0001), with a mean vessel wall area difference of 6.8 ± 2.7 mm2 between contrasts, and a ratio of T1W to T2W vessel wall area of 1.67 ± 0.28. The difference is attributed to a significantly (P < 0.0001) shorter T2 relaxation in the adventitia (T2 = 52.6 ± 3.5 ms) compared with the neointima/media (T2 = 174.7 ± 12.1 ms). Notably, adventitial tissue exhibits biexponential T2 signal decay (P < 0.0001 vs monoexponential). Our results suggest that high-resolution black blood 3D IV-FSE can be useful for studying the biology of bypass graft wall maturation and pathophysiology in vivo, by enabling independent visualization of the relative remodeling of the neointima/media and adventitia. Magn Reson Med, 2009. © 2009 Wiley-Liss, Inc.
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