Note

T measurement during first-pass contrast-enhanced cardiac perfusion imaging^†

Corresponding Author

Peter Kellman

[email protected]

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, 10 Center Drive, MSC-1061, Building 10, Room B1D416, Bethesda, MD 20892-1061===Search for more papers by this author

Anthony H. Aletras,

Anthony H. Aletras

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Li-yueh Hsu,

Li-yueh Hsu

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Elliot R. McVeigh,

Elliot R. McVeigh

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Andrew E. Arai,

Andrew E. Arai

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Peter Kellman,

Corresponding Author

Peter Kellman

[email protected]

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

Anthony H. Aletras,

Anthony H. Aletras

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Li-yueh Hsu,

Li-yueh Hsu

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Elliot R. McVeigh,

Elliot R. McVeigh

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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Andrew E. Arai,

Andrew E. Arai

Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA

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First published: 06 October 2006

https://doi.org/10.1002/mrm.21061

Citations: 23

^†

This article is a US Government work and, as such, is in the public domain in the United States of America.

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Abstract

First-pass contrast-enhanced (CE) myocardial perfusion imaging will experience T urn:x-wiley:07403194:media:MRM21061:tex2gif-stack-3 effects at peak concentrations of contrast agent. A reduction in the signal intensity of left ventricular (LV) blood due to T losses may effect estimates of the arterial input function (AIF) used for quantitative perfusion measurement. Imaging artifacts may also result from T urn:x-wiley:07403194:media:MRM21061:tex2gif-stack-5 losses as well as off-resonance due to the bolus susceptibility. We hypothesized that T losses would not be significant for measurement of the AIF in full-dose studies using a short echo time (TE = 0.6 ms). The purpose of this study was to directly measure T urn:x-wiley:07403194:media:MRM21061:tex2gif-stack-7 in the LV cavity during first-pass perfusion. For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T signal intensity loss will be less than 10% using TE = 0.6 ms. Magn Reson Med, 2006. Published 2006 Wiley-Liss, Inc.

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Volume56, Issue5

November 2006

Pages 1132-1134

T measurement during first-pass contrast-enhanced cardiac perfusion imaging^†

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T measurement during first-pass contrast-enhanced cardiac perfusion imaging†

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T measurement during first-pass contrast-enhanced cardiac perfusion imaging^†