Aluminum NMR is proposed as a new imaging and spectroscopy modality. Its potential is exemplified by in vivo studies of the human stomach. The dissolution kinetics of aluminum-containing drugs at physiological doses and their removal from the human stomach have been followed by ²⁷Al magnetic resonance spectroscopy (MRS). Aluminum concentrations as low as 0.5 mg Al³⁺ in the human stomach can be detected. The time course of gastric emptying has been visualized with ²⁷Al magnetic resonance imaging (MRI) under normal conditions and in the presence of an antimuscarinic agent, which reduces the gastric motor function. ²⁷Al MRI is the only direct method to visualize the gastric pH. ²⁷Al MRI opens new possibilities for medical and pharmaceutical science.

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Volume36, Issue2

August 1996

Pages 177-182

Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen

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Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen

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