Determination of regional blood volume and intra-extracapillary water exchange in human myocardium using Feruglose: First clinical results in patients with coronary artery disease
Corresponding Author
Christian M. Wacker
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Dept. of Cardiology, University of Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany===Search for more papers by this authorFrank Wiesmann
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorMichael Bock
Research program “Radiological Diagnostics and Therapy,” German Cancer Research Center (DKFZ), Heidelberg, Germany
Search for more papers by this authorPeter Jakob
Department of Biophysics (EP V), University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorJörn J.W. Sandstede
Department of Radiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorGeorg Ertl
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorLothar R. Schad
Research program “Radiological Diagnostics and Therapy,” German Cancer Research Center (DKFZ), Heidelberg, Germany
Search for more papers by this authorAxel Haase
Department of Biophysics (EP V), University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorWolfgang R. Bauer
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorCorresponding Author
Christian M. Wacker
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Dept. of Cardiology, University of Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany===Search for more papers by this authorFrank Wiesmann
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorMichael Bock
Research program “Radiological Diagnostics and Therapy,” German Cancer Research Center (DKFZ), Heidelberg, Germany
Search for more papers by this authorPeter Jakob
Department of Biophysics (EP V), University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorJörn J.W. Sandstede
Department of Radiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorGeorg Ertl
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorLothar R. Schad
Research program “Radiological Diagnostics and Therapy,” German Cancer Research Center (DKFZ), Heidelberg, Germany
Search for more papers by this authorAxel Haase
Department of Biophysics (EP V), University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorWolfgang R. Bauer
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany
Search for more papers by this authorAbstract
The aim of this pilot study in humans was to investigate the effect of an intravascular contrast agent (CA) on relaxation rate in myocardium (R1,myo) in the steady state. The dependence of R1,myo on R1,blood was characterized and compared with a theoretical model which allowed determination of the intra- extracapillary water proton exchange frequency (f = 0.48 s−1) and the intracapillary blood volume (RBV = 12.9 %). A linear response range of ΔR1,myo on ΔR1,blood was estimated which in future studies will allow the determination of RBV with intravascular CA. Magn Reson Med 47:1013–1016, 2002. © 2002 Wiley-Liss, Inc.
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