Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking
Corresponding Author
Susumu Mori
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
Dept. of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Bldg., 720 Rutland Ave., Baltimore, MD 21205===Search for more papers by this authorWalter E. Kaufmann
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorChristos Davatzikos
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorBram Stieltjes
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
Search for more papers by this authorLaura Amodei
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorKim Fredericksen
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorGodfrey D. Pearlson
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorElias R. Melhem
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorMeiyappan Solaiyappan
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorGerald V. Raymond
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorHugo W. Moser
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorPeter C.M. van Zijl
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
Search for more papers by this authorCorresponding Author
Susumu Mori
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
Dept. of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Bldg., 720 Rutland Ave., Baltimore, MD 21205===Search for more papers by this authorWalter E. Kaufmann
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorChristos Davatzikos
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorBram Stieltjes
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
Search for more papers by this authorLaura Amodei
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorKim Fredericksen
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorGodfrey D. Pearlson
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorElias R. Melhem
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorMeiyappan Solaiyappan
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorGerald V. Raymond
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorHugo W. Moser
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorPeter C.M. van Zijl
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
Search for more papers by this authorAbstract
Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated. Magn Reson Med 47:215–223, 2002. © 2002 Wiley-Liss, Inc.
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