Microwave and Optical Technology Letters

Volume 53, Issue 11 pp. 2583-2586

Formation of bowtie-shaped excitation in a photonic–microfluidic integrated devices

Benjamin R. Watts,

Benjamin R. Watts

Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Thomas Kowpak,

Thomas Kowpak

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Zhiyi Zhang,

Corresponding Author

Zhiyi Zhang

[email protected]

Institute for Microstructural Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON, Canada K1A 0R6

Zhiyi Zhang, Institute for Microstructural Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON, Canada K1A 0R6

Chang-Qing Xu, Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Chang-Qing Xu,

Corresponding Author

Chang-Qing Xu

[email protected]

Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

Zhiyi Zhang, Institute for Microstructural Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON, Canada K1A 0R6

Chang-Qing Xu, Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Shiping Zhu,

Shiping Zhu

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Benjamin R. Watts,

Benjamin R. Watts

Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Thomas Kowpak,

Thomas Kowpak

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Zhiyi Zhang,

Corresponding Author

Zhiyi Zhang

[email protected]

Institute for Microstructural Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON, Canada K1A 0R6

Zhiyi Zhang, Institute for Microstructural Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON, Canada K1A 0R6

Chang-Qing Xu, Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Chang-Qing Xu,

Corresponding Author

Chang-Qing Xu

[email protected]

Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

Zhiyi Zhang, Institute for Microstructural Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON, Canada K1A 0R6

Chang-Qing Xu, Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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Shiping Zhu,

Shiping Zhu

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L7

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First published: 19 August 2011

https://doi.org/10.1002/mop.26309

Citations: 2

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Abstract

Narrowly confining the beam intensity in a well-defined region in the center of cell flow is a necessary step to perform reliable flow cytometry testing but has so far not been achieved in a photonic–microfluidic integrated device.We were able to focus the excitation beam to a very narrow bowtie shape with a near uniform intensity across the flow stream for excitation for a flow cytometry application. Beam geometry was achieved by integrating a one-dimensional lens system with planar waveguides and a microfluidic channel on one substrate using one patterning material via a one-shot process. This letter reports the method used to achieve such shaped beams and the performance of the shaped beams. © 2011 National Research Council Canada & Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2583–2586, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26309

REFERENCES

1 J.V. Giorgi, J.L. Fahey, D.C. Smith, L.E. Hultin, H.L. Cheng, R.T. Mitsuyasu, and R. Detels, Early effects of HIV on CD4 Lymphocytesin vivo, J Immunol 138 ( 1987), 3725–3730.
PubMed Web of Science® Google Scholar
2 D. Campana and F.G. Behm, Immunophenotyping of leukemia, J Immunol Meth 243 ( 2000), 59–75.
10.1016/S0022-1759(00)00228-3
CAS PubMed Web of Science® Google Scholar
3 R.G. Ashcroft and P.A. Lopez, Commercial high speed machines open new opportunities in high throughput flow cytometry (HTFC), J Immunol Meth 243 ( 2000), 13–24.
10.1016/S0022-1759(00)00219-2
CAS PubMed Web of Science® Google Scholar
4 F.W. Kuckuck, B.S. Edwards, and L.A. Sklar, High throughput flow cytometry, Cytom 44 ( 2001), 83–90.
10.1002/1097-0320(20010501)44:1<83::AID-CYTO1085>3.0.CO;2-O
CAS PubMed Web of Science® Google Scholar
5 S.P. Perfetto, P.K. Chattopadhyay, and M. Roederer, Seventeen-colour flow cytometry: Unravelling the immune system, Nat Rev Immunol 4 ( 2004), 648–655.
10.1038/nri1416
CAS PubMed Web of Science® Google Scholar
6 M.A. McClain, C.T. Culbertson, S.C. Jacobson, and J.M. Ramsey, Flow cytometry of Escherichia coli on microfluidic devices, Anal Chem 73 ( 2001), 5334–5338.
10.1021/ac010504v
CAS PubMed Web of Science® Google Scholar
7 N. Pamme, R. Koyama, and A. Manz, Counting and sizing of particles and particle agglomerates in a microfluidic device using laser light scattering: application of particle-enhanced immunoassay, Lab Chip 3 ( 2003), 187–192.
10.1039/b300876b
CAS PubMed Web of Science® Google Scholar
8 A. Wolff, I.R. Perch-Nielsen, U.D. Larsen, P. Friis, G. Goranovic, C.R. Poulsen, J.P. Kutter, and P. Telleman, Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter, Lab Chip 3 ( 2003), 22–27.
10.1039/b209333b
CAS PubMed Web of Science® Google Scholar
9 K.B. Mogensen, J. El-Ali, A. Wolff, and J.P. Kutter, Integration of polymer waveguides for optical detection in microfabricated chemical analysis systems, App Opt 42 ( 2003), 4072–4079.
10.1364/AO.42.004072
CAS PubMed Web of Science® Google Scholar
10 O. Hofmann, X. Wang, A. Cornwell, S. Beecher, A. Raja, D.D. C. Bradley, A.J. deMello, and J.C. deMello, Monolithically integrated dye-doped PDMS long-pass filters for disposable on-chip fluorescence detection, Lab Chip 6 ( 2006), 981–987.
10.1039/b603678c
CAS PubMed Web of Science® Google Scholar
11 S. Balslev, A.M. Jorgensen, B. Bilenberg, K.B. Mogensen, D. Snakenborg, O. Geschke, J.P. Kutter, and A. Kristensen, Lab-on-a-chip with integrated optical transducers, Lab Chip 6 ( 2006), 213–217.
10.1039/B512546D
CAS PubMed Web of Science® Google Scholar
12 K.W. Ro, K. Lim, B.C. Shim, and J.H. Hahn, Integrated light collimating system for extended optical-path-length absorbance detection in microchip-based capillary electrophoresis, Anal Chem 77 ( 2005), 5160–5166.
10.1021/ac050420c
CAS PubMed Web of Science® Google Scholar
13 C.L. Bliss, J.N. McMullin, and C.J. Backhouse, Integrated wavelength-selective optical waveguide for microfluidic-based laser-induced fluorescence detection, Lab Chip 8 ( 2008), 143–151.
10.1039/B711601B
CAS PubMed Web of Science® Google Scholar
14 S. Camou, H. Fujita, and T. Fujii, PDMS 2D optical lens integrated with microfluidic channels: Principle and characterization, Lab Chip 3 ( 2003), 40–45.
10.1039/b211280a
CAS PubMed Web of Science® Google Scholar
15 S-K. Hsiung, C-H. Lin, and G-B. Lee, A microfabricated capillary electrophoresis chip with multiple buried optical fibres and microfocusing lens for multiwavelength detection, Electrophor 5 ( 2005), 1122–1129.
10.1002/elps.200410034
CAS Web of Science® Google Scholar
16 J. Seo and L.P. Lee, Disposable integrated microfluidics with self-aligned planar microlenses, Sens Act B 99 ( 2004), 615–622.
10.1016/j.snb.2003.11.014
CAS Web of Science® Google Scholar
17 Z. Wang, J. El-Ali, M. Engelund, T. Gotsaed, I.R. Perch-Nielsen, K.B. Mogensen, D. Snakenborg, J.P. Kutter, and A. Wolff, Measurements of scattered light on a microchip flow cytometer with integrated polymer based optical elements, Lab Chip 4 ( 2004), 372–377.
10.1039/B400663A
CAS PubMed Web of Science® Google Scholar

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Volume53, Issue11

November 2011

Pages 2583-2586

Formation of bowtie-shaped excitation in a photonic–microfluidic integrated devices

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Formation of bowtie-shaped excitation in a photonic–microfluidic integrated devices

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