Drug-Loaded Mitochondrial Targeted Nanoparticles for Tumor Imaging and PDT/PTT Combined Chemotherapy in Muscle-Invasive Bladder Cancer
Yuandi Huang
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorZeyu Li
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorHeping Qiu
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorChongxing Shen
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorJianwu Wang
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorBenhuang Yan
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorJinjin Li
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorQiang Fang
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorCorresponding Author
Weibing Li
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Chunmeng Shi
Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400038 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Yi Zhi
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorYuandi Huang
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorZeyu Li
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorHeping Qiu
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorChongxing Shen
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorJianwu Wang
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorBenhuang Yan
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorJinjin Li
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorQiang Fang
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
Search for more papers by this authorCorresponding Author
Weibing Li
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Chunmeng Shi
Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400038 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Yi Zhi
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Neoadjuvant chemotherapy combined with radical cystectomy is the standard treatment for muscle-invasive bladder cancer (MIBC). While cisplatin-based regimens reduce postoperative recurrence, their severe toxicity often limits clinical application. Moreover, the need for urinary diversion after radical cystectomy significantly impacts quality of life, leading to reluctance toward surgery. Therefore, developing tumor-targeted therapies and alternative treatment strategies for MIBC is of great clinical significance. In this study, the IR780 iodide multifunctional dye is conjugated to alginate polysaccharide and developed a novel cisplatin-loaded nanoparticle. Then, the tumor targeting and antitumor effects of the nanoparticles are evaluated in vitro and in vivo. The results show that the nanoparticles have sufficient drug loading, enhanced tumor targeting, and good photothermal effect. Furthermore, they shows potential for tumor imaging and diagnostic applications in a mouse model of MIBC. This study proposes a potentially effective treatment for MIBC by combining near-infrared localized phototherapy with systemic chemotherapy to eliminate malignant tissue.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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