Insights into the Excited State Dynamics of Donor–Acceptor Organic Photosensitizer for Precise Deep-Brain Two-Photon Photodynamic Therapy
Hui Zhao
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072 China
Search for more papers by this authorMubin He
State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorTingchao He
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China
Search for more papers by this authorZizi Wu
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
Search for more papers by this authorYonghui Pan
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
Search for more papers by this authorJia Gao
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
Search for more papers by this authorXiaofei Miao
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China
Search for more papers by this authorJunzi Li
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China
Search for more papers by this authorCorresponding Author
Huili Ma
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorWei Huang
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072 China
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
Search for more papers by this authorCorresponding Author
Wenbo Hu
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Quli Fan
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorHui Zhao
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072 China
Search for more papers by this authorMubin He
State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorTingchao He
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China
Search for more papers by this authorZizi Wu
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
Search for more papers by this authorYonghui Pan
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
Search for more papers by this authorJia Gao
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
Search for more papers by this authorXiaofei Miao
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China
Search for more papers by this authorJunzi Li
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060 China
Search for more papers by this authorCorresponding Author
Huili Ma
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorWei Huang
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072 China
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211816 China
Search for more papers by this authorCorresponding Author
Wenbo Hu
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Quli Fan
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023 China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Organic photosensitizer with both large two-photon absorption (σ) and efficient intersystem crossing (ISC) offers incomparable advantages in precise two-photon photodynamic therapy. However, the current design strategy cannot achieve efficient ISC without compromising σ. Here, very efficient ISC and ultrahigh σ in organic photosensitizer (PFBT) for precise cerebrovascular two-photon photodynamic therapy is simultaneously achieved. A hybridized local and charge-transfer (1HLCT) excited state in PFBT, formed by incorporating benzothiadiazole into a typical polyfluorene (PF), is the key to initiating efficient ISC while bringing substantial σ enhancement (25 000 GM vs 10 000 GM) compared to PF. Mechanism studies identify that 1HLCT produces large spin-orbit coupling and tiny singlet-triplet energy gaps, together generating efficient ISC. These properties afford PFBT nanophotosensitizer a ≈2000-fold increase in two-photon photodynamic therapy efficiency than clinically-used Photofrin, enabling in vivo deep-brain cerebrovascular imaging and closure with unprecedented precision.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| lpor202300917-sup-0001-SuppMat.pdf2.4 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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