Systematic Review

Utility of Ultrasonography for Diagnosis of Salivary Gland Sialolithiasis: A Meta-Analysis

Do Hyun Kim MD, PhD

orcid.org/0000-0002-9248-5572

Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Do Hyun Kim and Jun Myung Kang are co-first authors.

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Jun Myung Kang MD, PhD,

Jun Myung Kang MD, PhD

orcid.org/0000-0003-1850-1439

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Do Hyun Kim and Jun Myung Kang are co-first authors.

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Sung Won Kim MD, PhD,

Sung Won Kim MD, PhD

orcid.org/0000-0002-8981-2536

Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

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So-Hyun Kim MD,

So-Hyun Kim MD

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

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Jae Hoon Jung MD,

Jae Hoon Jung MD

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

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Se Hwan Hwang MD, PhD,

Corresponding Author

Se Hwan Hwang MD, PhD

[email protected]

orcid.org/0000-0002-2838-7820

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Send correspondence to Se Hwan Hwang, MD, PhD, Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 327 Sosa-ro, Bucheon-si, Gyeonggi-do, 14647, South Korea. E-mail: [email protected]

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Do Hyun Kim MD, PhD,

Do Hyun Kim MD, PhD

orcid.org/0000-0002-9248-5572

Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Do Hyun Kim and Jun Myung Kang are co-first authors.

Search for more papers by this author

Jun Myung Kang MD, PhD,

Jun Myung Kang MD, PhD

orcid.org/0000-0003-1850-1439

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Do Hyun Kim and Jun Myung Kang are co-first authors.

Search for more papers by this author

Sung Won Kim MD, PhD,

Sung Won Kim MD, PhD

orcid.org/0000-0002-8981-2536

Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Search for more papers by this author

So-Hyun Kim MD,

So-Hyun Kim MD

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Search for more papers by this author

Jae Hoon Jung MD,

Jae Hoon Jung MD

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Search for more papers by this author

Se Hwan Hwang MD, PhD,

Corresponding Author

Se Hwan Hwang MD, PhD

[email protected]

orcid.org/0000-0002-2838-7820

Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Search for more papers by this author

First published: 19 January 2022

https://doi.org/10.1002/lary.30020

Citations: 1

Editor's Note: This Manuscript was accepted for publication on January 01, 2022

d.h.k. and j.m.k. contributed equally to this work.

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01051844) and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (2019M3A9H2032424, 2019M3E5D5064110). The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives

We hypothesized that ultrasonography for salivary gland stone detection would have a diagnostic accuracy similar to that confirmed by sialendoscopy, sialography, or surgery. Therefore, we evaluated the diagnostic characteristics of ultrasonography in terms of submandibular and parotid stone detection compared to confirmatory methods.

Methods

We searched PubMed, Embase, the Web of Science, SCOPUS, and the Cochrane database to October 31, 2021. The risk of bias was evaluated using the QADAS-2 tool.

Results

Ten studies involving 1393 patients were included in the analysis. The diagnostic odds ratio of ultrasonography was 162.6013 (95% confidence interval [CI] [53.9883; 489.7208] and I² value 81.0%). The area under the summary receiver operating characteristic curve was 0.963. The sensitivity, specificity, negative predictive value, and positive predictive value were 0.8992 (95% CI [0.8534; 0.9318]; I² = 79.9%), 0.9664 (95% CI [0.9290; 0.9844], I² = 65.6%), 0.8076 (95% CI [0.7256; 0.8694]; I² = 80.4%), and 0.9853 (95% CI [0.9629; 0.9943]; I² = 77.4%), respectively. However, high-level among-study heterogeneity (I² ≥ 50%) was evident, attributable to the inclusion of different glands. On subgroup analysis, significant differences in the negative predictive values (parotid gland only [0.9392], submandibular gland only [0.6718], and parotid and submandibular glands [0.8105]) were apparent. We found no significant among-study difference in the sensitivity, specificity, positive predictive value, or diagnostic odds ratio (P > .05).

Conclusion

Ultrasonography usefully detects submandibular and parotid gland stones. Ultrasonography of the parotid gland was associated with the highest diagnostic accuracy, but further clinical studies are needed.

Level of Evidence

NA Laryngoscope, 132:1785–1791, 2022

Supporting Information

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Citing Literature

Volume132, Issue9

September 2022

Pages 1785-1791

Filename	Description
lary30020-sup-0001-Table 1.docxWord 2007 document , 19.7 KB	Supporting Table 1 Search terms and queries.
lary30020-sup-0002-Table 2.docxWord 2007 document , 17.6 KB	Supporting Table 2 Characteristics of included studies.
lary30020-sup-0003-Table 3.docxWord 2007 document , 14.8 KB	Supporting Table 3 Methodological qualities of the studies.

Utility of Ultrasonography for Diagnosis of Salivary Gland Sialolithiasis: A Meta-Analysis

Abstract

Objectives

Methods

Results

Conclusion

Level of Evidence

Supporting Information

BIBLIOGRAPHY

Citing Literature

References

Information

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Utility of Ultrasonography for Diagnosis of Salivary Gland Sialolithiasis: A Meta-Analysis

Abstract

Objectives

Methods

Results

Conclusion

Level of Evidence

Supporting Information

BIBLIOGRAPHY

Citing Literature

References

Related

Information