Volume 131, Issue 4 pp. E1209-E1213

Original Report

Soft Tissue Metastases in Head and Neck Cutaneous Squamous Cell Carcinoma

Craig P. Mooney MBBS,

Corresponding Author

Craig P. Mooney MBBS

[email protected]

orcid.org/0000-0003-4200-1610

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Sydney Medical School, University of Sydney, Sydney, Australia

Send correspondence to Craig P. Mooney, MBBS, The Chris O'Brien Lifehouse 119-143 Missenden Road, Camperdown, New South Wales, 2050, Australia. E-mail: [email protected]

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Kan Gao BEng,

Kan Gao BEng

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

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Jonathan R. Clark MBBS, MD,

Jonathan R. Clark MBBS, MD

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Sydney, Australia

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Ruta Gupta MD,

Ruta Gupta MD

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Sydney, Australia

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Kerwin Shannon MBBS,

Kerwin Shannon MBBS

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

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Carsten E. Palme MBBS,

Carsten E. Palme MBBS

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

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Ardalan Ebrahimi MBBS,

Ardalan Ebrahimi MBBS

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Medical School, College of Health and Medicine, Australian National University, Canberra, Australia

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Sydney Ch'ng MD,

Sydney Ch'ng MD

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

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Tsu-Hui (Hubert) Low MBBS,

Tsu-Hui (Hubert) Low MBBS

orcid.org/0000-0001-8958-736X

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

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Craig P. Mooney MBBS,

Corresponding Author

Craig P. Mooney MBBS

[email protected]

orcid.org/0000-0003-4200-1610

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Sydney Medical School, University of Sydney, Sydney, Australia

Send correspondence to Craig P. Mooney, MBBS, The Chris O'Brien Lifehouse 119-143 Missenden Road, Camperdown, New South Wales, 2050, Australia. E-mail: [email protected]

Search for more papers by this author

Kan Gao BEng,

Kan Gao BEng

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Search for more papers by this author

Jonathan R. Clark MBBS, MD,

Jonathan R. Clark MBBS, MD

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Sydney, Australia

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Ruta Gupta MD,

Ruta Gupta MD

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Sydney, Australia

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Kerwin Shannon MBBS,

Kerwin Shannon MBBS

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

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Carsten E. Palme MBBS,

Carsten E. Palme MBBS

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

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Ardalan Ebrahimi MBBS,

Ardalan Ebrahimi MBBS

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Medical School, College of Health and Medicine, Australian National University, Canberra, Australia

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Sydney Ch'ng MD,

Sydney Ch'ng MD

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

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Tsu-Hui (Hubert) Low MBBS,

Tsu-Hui (Hubert) Low MBBS

orcid.org/0000-0001-8958-736X

Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia

Central Clinical School, University of Sydney, Sydney, Australia

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First published: 14 September 2020

https://doi.org/10.1002/lary.29064

Citations: 3

Editor's Note: This Manuscript was accepted for publication on August 11, 2020.

The authors have no funding or conflicts of interest to declare.

The contents of this article were presented as an oral presentation at the Australian Society Otolaryngology, Head and Neck Surgery Annual Scientific Meeting 2019, Brisbane, March 22–24, 2019.

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Abstract

Objective

Soft tissue metastases (STM) in head and neck cutaneous squamous cell carcinoma (HNcSCC) are non-nodal based metastases to the parotid and cervical soft tissues of the head and neck. This is a unique subgroup of regional metastases amongst patients with cSCC and have been shown to be associated with poor prognosis. Detailed studies of this subgroup are lacking in the literature. A retrospective cohort analysis was performed to characterize the prognostic significance of STM in HNcSCC based on individual clinicopathological features.

Methods

Patients with HNcSCC with STM were identified from the Sydney Head and Neck Cancer Institute database. Clinicopathological characteristics were extracted from the histopathological reports. Recurrence and follow-up data were analyzed to determine disease-free and overall survival using the Kaplan–Meier method and Cox proportional hazards models.

Results

After excluding all patients with lymph node metastasis with no STM, there were 200 patients identified (161 parotid, 32 cervical, and seven with concurrent parotid and cervical STM) with a 5-year overall survival of 36%. In univariable analysis, age of patients, size of the deposits, location of the deposits, and patients that were not offered adjuvant radiotherapy have worse overall survival. However, on multivariable analysis, age and the number of STM deposits were independent factors that predict for worse survival.

Conclusion

The presence of STM in patients with HNcSCC is associated with poor prognosis. Increasing number of STM deposits, as well as involved margin of the regional excision, negatively impacted on the overall prognosis.

Level of Evidence

Level III – retrospective cohort study. Laryngoscope, 131:E1209–E1213, 2021

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Volume131, Issue4

April 2021

Pages E1209-E1213

Soft Tissue Metastases in Head and Neck Cutaneous Squamous Cell Carcinoma

Abstract

Objective

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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Soft Tissue Metastases in Head and Neck Cutaneous Squamous Cell Carcinoma

Abstract

Objective

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

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