Volume 131, Issue 4 pp. E1125-E1129

Original Report

Significance of Nodal Metastasis in Parotid Gland Acinar Cell Carcinoma

Peter Moon BS,

Peter Moon BS

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

These authors contributed equally to this work.

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Mahbuba Tusty BS,

Mahbuba Tusty BS

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

These authors contributed equally to this work.

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Vasu Divi MD,

Vasu Divi MD

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

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Uchechukwu C. Megwalu MD, MPH,

Corresponding Author

Uchechukwu C. Megwalu MD, MPH

[email protected]

orcid.org/0000-0001-5132-8864

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

Send correspondence to Uchechukwu Megwalu, MD, MPH, Department of Otolaryngology–Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305. E-mail: [email protected]Search for more papers by this author

Peter Moon BS,

Peter Moon BS

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

These authors contributed equally to this work.

Search for more papers by this author

Mahbuba Tusty BS,

Mahbuba Tusty BS

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

These authors contributed equally to this work.

Search for more papers by this author

Vasu Divi MD,

Vasu Divi MD

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

Search for more papers by this author

Uchechukwu C. Megwalu MD, MPH,

Corresponding Author

Uchechukwu C. Megwalu MD, MPH

[email protected]

orcid.org/0000-0001-5132-8864

Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Stanford University, Palo Alto, CA, U.S.A.

First published: 08 August 2020

https://doi.org/10.1002/lary.28966

Citations: 11

Editor's Note: This Manuscript was accepted for publication on June 30, 2020.

The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives

To evaluate the rate of lymph node metastasis in parotid gland acinar cell carcinoma, to identified factors associated with increased risk of metastasis, and to evaluate the effect of nodal metastasis on survival.

Methods

This is a retrospective cohort study utilizing data from a large population-based cancer database. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 database. The study cohort included patients with parotid gland acinar cell carcinoma diagnosed between 2000 and 2015.

Results

The overall rate of lymph node metastasis was 6.8%. T3/T4 (OR 6.17, 95% CI, 3.03 to 13.16) disease along with High Grade (OR 15.95) disease were associated with increased risk of nodal metastasis. Non-white, non-Black race was associated with decreased risk. Age and sex were not associated with nodal metastasis. Nodal metastasis was associated with worse OS (HR 6.27, 95% CI, 3.85 to 10.20) and DSS (HR 6.96, 95% CI, 3.81 to 12.73) after adjusting for covariates.

Conclusion

Parotid gland acinar cell carcinoma carries a low risk of nodal metastasis. Both advanced T stage and high grade are associated with increased risk of nodal metastasis. Nodal metastasis is associated with decreased overall survival.

Level of Evidence

3 Laryngoscope, 131:E1125–E1129, 2021

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Volume131, Issue4

April 2021

Pages E1125-E1129

Significance of Nodal Metastasis in Parotid Gland Acinar Cell Carcinoma

Abstract

Objectives

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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Significance of Nodal Metastasis in Parotid Gland Acinar Cell Carcinoma

Abstract

Objectives

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

Information