Volume 130, Issue 12 pp. 2847-2852

Laryngology

Therapeutic Efficacy of Basic Fibroblast Growth Factor in Patients With Vocal Fold Atrophy

Ayako Okui MD,

Corresponding Author

Ayako Okui MD

[email protected]

orcid.org/0000-0002-0836-4875

Tokyo Voice Center, International University of Health and Welfare, Tokyo

Graduate School of Medicine, International University of Health and Welfare Graduate School, Tokyo

Send correspondence to Ayako Okui, MD, Tokyo Voice Center, International University of Health and Welfare, 8-10-16 Akasaka, Minato-ku, Tokyo 107-0052, Japan. E-mail: [email protected]Search for more papers by this author

Ujimoto Konomi MD, PhD,

Ujimoto Konomi MD, PhD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Takeharu Kanazawa MD, PhD,

Takeharu Kanazawa MD, PhD

orcid.org/0000-0002-3735-684X

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Daigo Komazawa MD,

Daigo Komazawa MD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Kazuhiro Nakamura MD, PhD,

Kazuhiro Nakamura MD, PhD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

Department of Otolaryngology–Head and Neck Surgery, Nihon University, Itabashi Hospital, Tokyo

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Koji Matsushima MD, PhD,

Koji Matsushima MD, PhD

orcid.org/0000-0002-6739-3289

Tokyo Voice Center, International University of Health and Welfare, Tokyo

Department of Otolaryngology–Head and Neck Surgery, Toho University, Omori Medical Center, Tokyo, Japan

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Yusuke Watanabe MD, PhD,

Yusuke Watanabe MD, PhD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Ayako Okui MD,

Corresponding Author

Ayako Okui MD

[email protected]

orcid.org/0000-0002-0836-4875

Tokyo Voice Center, International University of Health and Welfare, Tokyo

Graduate School of Medicine, International University of Health and Welfare Graduate School, Tokyo

Ujimoto Konomi MD, PhD,

Ujimoto Konomi MD, PhD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Takeharu Kanazawa MD, PhD,

Takeharu Kanazawa MD, PhD

orcid.org/0000-0002-3735-684X

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Daigo Komazawa MD,

Daigo Komazawa MD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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Kazuhiro Nakamura MD, PhD,

Kazuhiro Nakamura MD, PhD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

Department of Otolaryngology–Head and Neck Surgery, Nihon University, Itabashi Hospital, Tokyo

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Koji Matsushima MD, PhD,

Koji Matsushima MD, PhD

orcid.org/0000-0002-6739-3289

Tokyo Voice Center, International University of Health and Welfare, Tokyo

Department of Otolaryngology–Head and Neck Surgery, Toho University, Omori Medical Center, Tokyo, Japan

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Yusuke Watanabe MD, PhD,

Yusuke Watanabe MD, PhD

Tokyo Voice Center, International University of Health and Welfare, Tokyo

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First published: 08 February 2020

https://doi.org/10.1002/lary.28541

Citations: 16

Editor's Note: This Manuscript was accepted for publication on January 13, 2020.

The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives/Hypothesis

In recent years, basic fibroblast growth factor (bFGF) injection has been used in the treatment of aging-related vocal fold atrophy. This injection not only improves closure by increasing the mass of the vocal fold but also improves its viscoelasticity. However, it has been reported that fibroblasts targeted by bFGF treatment decrease in number with age. The purpose of this study was to examine the effects of local injection of bFGF on age-related vocal atrophy as well as the influence of age on phonological outcomes.

Study Design

Retrospective chart review.

Methods

Fifty-three patients with age-related vocal fold atrophy underwent single injections of bFGF in their vocal folds. Phonological outcomes were evaluated 3 and 6 months after injection by acoustic and aerodynamic measurements.

Results

Voice Handicap Index (VHI), maximum phonation time (MPT), jitter, shimmer, and pitch range improved after injection, and the effects continued for 6 months. In those over 70 years of age, VHI and MPT showed improvement at 3 and 6 months after injection. In addition, the degree of improvement in VHI and MPT did not differ significantly between those older than 70 years and those younger than 70 years.

Conclusions

Regenerative treatments dependent on bFGF single injection was safe and effective for both early and late elderly patients suffering of vocal fold atrophy.

Level of Evidence

2c Laryngoscope, 2020

BIBLIOGRAPHY

1Roy N, Stemple J, Merrill RM, Thomas L. Epidemiology of voice disorders in the elderly: preliminary findings. Laryngoscope 2007; 117: 628-633.
10.1097/MLG.0b013e3180306da1
PubMed Web of Science® Google Scholar
2Sato K, Hirano M, Nakashima T. Age-related changes of collagenous fibers in the human vocal fold mucosa. Ann Otol Rhinol Laryngol 2002; 111: 15-20.
10.1177/000348940211100103
PubMed Web of Science® Google Scholar
3Sato T. Age changes in human vocal muscle. Mech Ageing Dev 1982; 18: 67-74.
10.1016/0047-6374(82)90031-8
CAS PubMed Web of Science® Google Scholar
4Ford CN, Bless DM, Loftus JM. Role of injectable collagen in the treatment of glottic insufficiency: a study of 119 patients. Ann Otol Rhinol Laryngol 1992; 101: 237-247.
10.1177/000348949210100307
CAS PubMed Web of Science® Google Scholar
5Young VN, Gartner-Schmidt J, Rosen CA. Comparison of voice outcomes after trial and long-term vocal fold augmentation in vocal fold atrophy. Laryngoscope 2015; 125: 934-940.
10.1002/lary.25043
PubMed Web of Science® Google Scholar
6Hsiung MW, Lin YS, Su WF, Wang HW. Autogenous fat injection for vocal fold atrophy. Eur Arch Otorhinolaryngol 2003; 260: 469-474.
10.1007/s00405-003-0622-y
PubMed Web of Science® Google Scholar
7Isshiki N, Shoji K, Kojima H, Hirano S. Vocal fold atrophy and its surgical treatment. Ann Otol Rhinol Laryngol 1996; 105: 182-188.
10.1177/000348949610500303
CAS PubMed Web of Science® Google Scholar
8Gartner-Schmidt J, Rosen C. Treatment success for age-related vocal fold atrophy. Laryngoscope 2011; 121: 585-589.
10.1002/lary.21122
PubMed Web of Science® Google Scholar
9Hirano S, Nagai H, Tateya I, Tateya T, Ford CN, Bless DM. Regeneration of aged vocal folds with basic fibroblast growth factor in a rat model: a preliminary report. Ann Otol Rhinol Laryngol 2005; 114: 304-308.
10.1177/000348940511400409
PubMed Web of Science® Google Scholar
10Hirano S, Bless DM, del Río AM, Connor NP, Ford CN. Therapeutic potential of growth factors for aging voice. Laryngoscope 2004; 114: 2161-2167.
10.1097/01.mlg.0000149450.37640.db
CAS PubMed Web of Science® Google Scholar
11Hirano S, Kishimoto Y, Suehiro A, Kanemaru S, Ito J. Regeneration of aged vocal fold: first human case treated with fibroblast growth factor. Laryngoscope 2008; 118: 2254-2259.
10.1097/MLG.0b013e3181845720
PubMed Web of Science® Google Scholar
12Suzuki H, Makiyama K, Hirai R, Matsuzaki H, Furusaka T, Oshima T. Efficacy of a single dose of basic fibroblast growth factor: clinical observation for 1 year. J Voice 2016; 30: 761.e11-761.e17.
10.1016/j.jvoice.2015.09.018
Web of Science® Google Scholar
13Ohno S, Hirano S, Yasumoto A, Ikeda H, Takebayashi S, Miura M. Outcome of regenerative therapy for age-related vocal fold atrophy with basic fibroblast growth factor. Laryngoscope 2016; 126: 1844-1848.
10.1002/lary.25578
CAS PubMed Web of Science® Google Scholar
14Woo P. Hyaluronidase injection in the vocal folds for vocal hemorrhage, Reinke edema, and hyaluronic acid overinjection: a novel application in the larynx. J Voice 2018; 32: 492-498.
10.1016/j.jvoice.2017.07.004
PubMed Web of Science® Google Scholar
15Karpenko AN, Dworkin JP, Meleca RJ, Stachler RJ. Cymetra injection for unilateral vocal fold paralysis. Ann Otol Rhinol Laryngol 2003; 112: 927-934.
10.1177/000348940311201103
PubMed Web of Science® Google Scholar
16M Dominguez L, Villarreal R, Simpson CB. Voice outcomes of lipoinjection versus medialization laryngoplasty for nonparalytic glottic insufficiency. Laryngoscope 2018; 129: 1164-1168.
10.1002/lary.27573
PubMed Web of Science® Google Scholar
17van den Broek EMJM, Heijnen BJ, Hendriksma M, et al. Bilateral vocal fold injection with autologous fat in patients with vocal fold atrophy with or without sulcus. Eur Arch Otorhinolaryngol 2019; 276: 2007-2013.
10.1007/s00405-019-05479-5
PubMed Web of Science® Google Scholar
18van den Broek EMJM, Heijnen BJ, Hendriksma M, Langeveld APM, van Benthem PPG, Sjögren EV. Bilateral trial vocal fold injection with hyaluronic acid in patients with vocal fold atrophy with or without sulcus. Eur Arch Otorhinolaryngol 2019; 276: 1413-1422.
10.1007/s00405-019-05347-2
PubMed Web of Science® Google Scholar
19Kimura M, Nito T, Sakakibara K, Tayama N, Niimi S. Clinical experience with collagen injection of the vocal fold: a study of 155 patients. Auris Nasus Larynx 2008; 35: 67-75.
10.1016/j.anl.2007.07.005
PubMed Web of Science® Google Scholar
20Suehiro A, Hirano S, Kishimoto Y, Rousseau B, Nakamura T, Ito J. Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor: a canine study. Acta Otolaryngol 2010; 130: 844-850.
10.3109/00016480903426618
CAS PubMed Web of Science® Google Scholar
21Kaneko M, Tsuji T, Kishimoto Y, Sugiyama Y, Nakamura T, Hirano S. Regenerative effects of basic fibroblast growth factor on restoration of thyroarytenoid muscle atrophy caused by recurrent laryngeal nerve transection. J Voice 2018; 32: 645-651.
10.1016/j.jvoice.2017.09.019
PubMed Web of Science® Google Scholar
22Hirano S, Tateya I, Kishimoto Y, Kanemaru S, Ito J. Clinical trial of regeneration of aged vocal folds with growth factor therapy. Laryngoscope 2012; 122: 327-331.
10.1002/lary.22393
CAS PubMed Web of Science® Google Scholar
23Sato K, Hirano M. Age-related changes of the macula flava of the human vocal fold. Ann Otol Rhinol Laryngol 1995; 104: 839-844.
10.1177/000348949510401102
CAS PubMed Web of Science® Google Scholar
24Hirano M, Sato K, Nakashima T. Fibroblasts in human vocal fold mucosa. Acta Otolaryngol 1999; 119: 271-276.
10.1080/00016489950181800
CAS PubMed Web of Science® Google Scholar
25Goto T, Ueha R, Sato T, Fujimaki Y, Nito T, Yamasoba T. Single, high-dose local injection of bFGF improves thyroarytenoid muscle atrophy after paralysis. Laryngoscope 2020; 130: 159-165.
10.1002/lary.27887
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume130, Issue12

December 2020

Pages 2847-2852

Therapeutic Efficacy of Basic Fibroblast Growth Factor in Patients With Vocal Fold Atrophy

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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Therapeutic Efficacy of Basic Fibroblast Growth Factor in Patients With Vocal Fold Atrophy

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

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