Laryngology

Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta-analysis

Corresponding Author

R. Jun Lin MD, FRCSC, MSc

[email protected]

Department of Otolaryngology–Head and Neck Surgery, University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada

Send correspondence to R. Jun Lin, MD, FRCSC, MSc, Assistant Professor, University of Toronto, Associate Scientist, Li Ka Shing Knowledge Institute, Department of Otolaryngology–Head and Neck Surgery, Laryngology, St. Michael's Hospital, 30 Bond Street, 8-163 CC North, Toronto, Ontario, Canada M5B 1W8. E-mail: [email protected]Search for more papers by this author

Michele Klein-Fedyshin MSLS, BSN, RN, AHIP,

Michele Klein-Fedyshin MSLS, BSN, RN, AHIP

Health Sciences Library System (HSLS), Research, Instruction, and Clinical Information Services Department, University of Pittsburgh, Pittsburgh, Pennsylvania

Search for more papers by this author

Clark A. Rosen MD, FACS,

Clark A. Rosen MD, FACS

UCSF Voice and Swallowing Center, Department of Otolaryngology–Head and Neck Surgery, University of California, San Francisco, San Francisco, California, U.S.A.

Search for more papers by this author

R. Jun Lin MD, FRCSC, MSc,

Corresponding Author

R. Jun Lin MD, FRCSC, MSc

[email protected]

Department of Otolaryngology–Head and Neck Surgery, University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada

Michele Klein-Fedyshin MSLS, BSN, RN, AHIP,

Michele Klein-Fedyshin MSLS, BSN, RN, AHIP

Health Sciences Library System (HSLS), Research, Instruction, and Clinical Information Services Department, University of Pittsburgh, Pittsburgh, Pennsylvania

Search for more papers by this author

Clark A. Rosen MD, FACS,

Clark A. Rosen MD, FACS

UCSF Voice and Swallowing Center, Department of Otolaryngology–Head and Neck Surgery, University of California, San Francisco, San Francisco, California, U.S.A.

Search for more papers by this author

First published: 19 November 2018

https://doi.org/10.1002/lary.27530

Citations: 33

Presented as a podium presentation at the American Laryngological Association Annual Meeting at Combined Otolaryngology Spring Meetings (COSM), National Harbor, Maryland, U.S.A., April 19, 2018.

The authors have no funding, financial relationships, or conflicts of interest to disclose.

Share a link

Email
Wechat
Bluesky

Abstract

Introduction

Nimodipine is a calcium channel blocker that has been used to treat hypertension and vasospasm. Emerging evidence in the literature suggests that it is neuroprotective by reducing cellular apoptosis after neuronal injury and promoting axonal sprouting at the nodes of Ranvier.

Objectives

To conduct a systematic review of the usage of nimodipine in cranial nerve injury and to perform a meta-analysis to estimate the efficacy of nimodipine on functional recovery of the injured cranial nerves.

Methods

Literature search was performed in eight databases using preferred reporting items for systematic reviews and meta analyses (PRISMA) guidelines. Human studies that used nimodipine as a monotherapy for treating cranial nerve injury were included for review. Cranial nerve function recovery was the primary outcome measure.

Results

672 records were screened and 58 full texts in English were assessed. Nine studies were included in the final review. 5 of these, including 110 participants who received nimodipine for either recurrent laryngeal nerve or facial nerve injury and 556 controls, were used for meta-analysis. Nimodipine significantly increased the odds of vocal fold motion recovery (odds ratio [OR] 13.73, 95% confidence interval [CI] 6.21, 30.38, P < .01), and the odds of facial motion recovery (OR 2.78, 95% CI 1.20, 6.44, P = .02). Overall, nimodipine-treated patients had significantly higher odds of recovering vocal fold or facial motion compared with controls (OR 6.09, 95% CI 3.41, 10.87, P < .01).

Conclusion

Existing evidence supports the positive effect of nimodipine on vocal fold and facial motion recovery after injury. Future research should focus on randomized clinical trials comparing recovery rates between nimodipine- and placebo-treated groups. Laryngoscope, 129:943–951, 2019

BIBLIOGRAPHY

1Agnoli A. The classification of calcium antagonists by the WHO expert committee: relevance in neurology. Cephalalalgia 1988; 8(suppl 8): 7–10.
10.1177/03331024880080S802
PubMed Web of Science® Google Scholar
2Yu FH, Catterall WA. The VFL-chanome: a protein super-family specialized for electrical signaling and ionic homeostasis. Sci STKE 2004; 2004: re15.
10.1126/stke.2532004re15
PubMed Google Scholar
3Monzani D, Genovese E, Pini LA, et al. Nimodipine in otolaryngology: from past evidence to clinical perspectives. Acta Otorhinolaryngol Ital 2015; 35: 135–145.
CAS PubMed Web of Science® Google Scholar
4Hydman J, Bjorck G, Persson E, Zedenius J, Mattsson P. Diagnosis and prognosis of iatrogenic injury of the recurrent laryngeal nerve. Ann Otol Rhinol Laryngol 2009; 118: 506–511.
10.1177/000348940911800709
PubMed Web of Science® Google Scholar
5Gomez TM, Spitzer NC. In vivo regulation of axon extension and pathfinding by growth-cone calcium transients. Nature 1999; 397: 350–355.
10.1038/16927
CAS PubMed Web of Science® Google Scholar
6Rosen CA, Smith L, Young V, Krishna P, Muldoon MF, Munin MC. Prospective investigation of nimodipine for acute vocal fold paralysis. Muscle Nerve 2014; 50: 114–118.
10.1002/mus.24111
CAS PubMed Web of Science® Google Scholar
7Guntinas-Lichius O, Martinez-Portillo F, Lebek J, et al. Nimodipine maintains in vivo the increase in GFAP and enhances the astroglial ensheathment of surviving motoneurons in the rat following permanent target deprivation. J Neurocytol 1997; 26: 241–248.
10.1023/A:1018592215557
CAS PubMed Google Scholar
8Angelov DN, Neiss WF, Streppel M, et al. Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve. J Neurosci 1996; 16: 1041–1048.
10.1523/JNEUROSCI.16-03-01041.1996
CAS PubMed Web of Science® Google Scholar
9Strauss C, Bischoff B, Neu M, et al. Vasocactive treatment for hearing preservation in acoustic neuroma surgery. J Neurosurg 2001; 95: 771–777.
10.3171/jns.2001.95.5.0771
CAS PubMed Web of Science® Google Scholar
10Scheller C, Strauss C, Fahlbusch R, et al. Delayed facial nerve paresis following acoustic neuroma resection and postoperative vasoactive treatment. Zentralbl Neurochir 2004; 65: 103–107.
10.1055/s-2004-816268
CAS PubMed Web of Science® Google Scholar
11Davies E, Knox E, Donaldson I. The usefulness of nimodipine, an L-calcium channel antagonists, in the treatment of tinnitus. Br J Audiol 1994; 24: 125–129.
10.3109/03005369409086559
Google Scholar
12Pianese CP, Hidalgo LO, Gonzalez RH, et al. New approaches to the management of peripheral vertigo; efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study. Otol Neurotol 2002; 23: 357–363.
10.1097/00129492-200205000-00023
PubMed Web of Science® Google Scholar
13 University of York, Center for Reviews and Dissemination. PROSPERO International Prospective Register of Systematic Reviews. Available at: http://www.crd.york.ac.uk/PROSPERO/. Accessed October 11, 2018.
Google Scholar
14Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analysis: the PRISMA statement. J Clin Epi 2009; 62: 1006–1012.
10.1016/j.jclinepi.2009.06.005
PubMed Web of Science® Google Scholar
15Rosen CA, Mau T, Remacle M, et al. Nomenclature proposal to describe vocal fold motion impairment. Eur Arch Otorhinolaryngol 2016; 273: 1995–1999.
10.1007/s00405-015-3663-0
PubMed Web of Science® Google Scholar
16Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomized trials. BMJ 2011; 343: d5928.
10.1136/bmj.d5928
PubMed Web of Science® Google Scholar
17Wells G, Shea B, O'connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Published 2000. Available at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
Google Scholar
18Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557–560.
10.1002/sim.1186
PubMed Google Scholar
19Lisbeth M, Consuelo P, Glenda C, et al. Evaluation of the effect of nimodipine o.d. (extended release) vs nimodipine t.i.d. in the treatment of peripheral vertigo. Curr Drug Deliv 2013; 10: 343–347.
10.2174/1567201811310030011
CAS PubMed Web of Science® Google Scholar
20Sridharan SS, Rosen CA, Smith LJ, Young VN, et al. Timing of nimodipine therapy for the treatment of vocal fold paralysis. Laryngoscope 2015; 125: 186–190.
10.1002/lary.24903
CAS PubMed Web of Science® Google Scholar
21Kunert P, Dziedzic T, Podgorska A, et al. Surgery for sporadic vestibular schwannoma. Part IV. Predictive factors influencing facial nerve function after surgery. Neurol Neurochir Pol 2016; 50: 36–44.
10.1016/j.pjnns.2015.11.006
PubMed Web of Science® Google Scholar
22Scheller K, Scheller C. Nimodipine promotes regeneration of peripheral facial nerve function after traumatic injury following maxillofacial surgery: an off-label pilot study. J Craniomaxillofac Surg 2012; 40: 427–434.
10.1016/j.jcms.2011.07.016
CAS PubMed Web of Science® Google Scholar
23Scheller C, Wienke A, Wurm F, et al. Neuroprotective efficacy of prophylactic enteral and parenteral nimodipine treatment in vestibular schwannoma surgery: a comparative study. J Neurol Surg A 2014; 75: 251–258.
Google Scholar
24Munin MC, Rosen CA, Zullo T. Utility of laryngeal electromyography in predicting recovery after vocal fold paralysis. Arch Phys Med Rehabil 2003; 84: 1150–1153.
10.1016/S0003-9993(03)00146-1
PubMed Web of Science® Google Scholar
25Rickert SM, Childs LF, Carey BT, et al. Laryngeal electromyography for prognosis of vocal fold palsy: a meta-analysis. Laryngoscope 2012; 122: 158–161.
10.1002/lary.22354
PubMed Web of Science® Google Scholar
26Rinaldi V, Casale M, Bressi F, et al. Facial nerve outcome after vestibular schwannoma surgery: our experience. J Neurol Surg B 2012; 73: 21–27.
10.1055/s-0032-1304559
PubMed Web of Science® Google Scholar
27Hydman J, Remahl S, Bjorck G, et al. Nimodipine improves reinnervation and neuromuscular function after injury to the recurrent laryngeal nerve in the rat. Ann Otol Rhinol Laryngol 2007; 116: 623–630.
10.1177/000348940711600811
PubMed Web of Science® Google Scholar
28Angelov DN, Neiss WF, Streppel M, et al. Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve. J Neurosci 1996; 16: 1041–1048.
10.1523/JNEUROSCI.16-03-01041.1996
CAS PubMed Web of Science® Google Scholar
29Lindsay RW, Heaton J, Edwards C, et al. Nimodipine accelerates functional recovery of the facial nerve after crush injury. Arch Facial Plast Surg 2010; 12: 49–52.
10.1001/archfacial.2009.95
PubMed Web of Science® Google Scholar
30Mattsson P, Aldskogius H, Svensson M. Nimodipine-induced improved survival rate of facial motor neurons following intracranial transection of the facial nerve in the adult rat. J Neurosurg 1999; 90: 760–765.
10.3171/jns.1999.90.4.0760
CAS PubMed Web of Science® Google Scholar
31Zorzela L, Golder S, Liu Y, et al. Quality of reporting in systematic reviews of adverse events: systematic review. BMJ 2014; 348: f7668.
10.1136/bmj.f7668
PubMed Web of Science® Google Scholar

Citing Literature

Volume129, Issue4

April 2019

Pages 943-951

Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta-analysis

Abstract

Introduction

Objectives

Methods

Results

Conclusion

BIBLIOGRAPHY

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta-analysis

Abstract

Introduction

Objectives

Methods

Results

Conclusion

BIBLIOGRAPHY

Citing Literature

References

Related

Information