Volume 129, Issue 8 pp. 1940-1944

Sleep Medicine

Clinical Trials in Obstructive Sleep Apnea: Recognizing Trends and Future Opportunities

Sameer K. Singh BA

orcid.org/0000-0002-6476-3969

Department of Otolaryngology–Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

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David Gu BA,

David Gu BA

Department of Otolaryngology–Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

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Robson Capasso MD,

Robson Capasso MD

Department of Otolaryngology–Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A

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Stanley Liu MD,

Stanley Liu MD

Department of Otolaryngology–Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A

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Christopher J. Gouveia MD,

Corresponding Author

Christopher J. Gouveia MD

[email protected]

Department of Otolaryngology–Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Department of Otolaryngology–Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A

Send correspondence to Christopher Gouveia, Department of Otolaryngology–Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305. E-mail: [email protected]Search for more papers by this author

Sameer K. Singh BA,

Sameer K. Singh BA

orcid.org/0000-0002-6476-3969

Department of Otolaryngology–Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Search for more papers by this author

David Gu BA,

David Gu BA

Department of Otolaryngology–Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

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Robson Capasso MD,

Robson Capasso MD

Department of Otolaryngology–Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A

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Stanley Liu MD,

Stanley Liu MD

Department of Otolaryngology–Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A

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Christopher J. Gouveia MD,

Corresponding Author

Christopher J. Gouveia MD

[email protected]

Department of Otolaryngology–Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Department of Otolaryngology–Head and Neck Surgery, Stanford University Medical Center, Stanford, California, U.S.A

First published: 03 October 2018

https://doi.org/10.1002/lary.27453

Citations: 1

Presented at the 2018 Triological Society Combined Sections Meeting, Scottsdale, Arizona, U.S.A., January 18–20, 2018.

The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives/Hypothesis

Examine US and international clinical trials in obstructive sleep apnea (OSA) to characterize researchers involved, interventions being studied, and opportunities for future investigation.

Study Design

Retrospective database review.

Methods

The information from ClinicalTrials.gov was used to assess OSA clinical trials between 1999 and 2017. Information was gathered on principle investigator (PI) demographics, interventions studied, study funding source, and regional distribution of research institutions.

Results

There were 813 clinical trials studied. The majority of trials examined continuous positive airway pressure interventions (43.7%), with pharmacotherapies being the second most commonly investigated treatment (19.2%). Surgical interventions made up 10.7% (n = 87) of clinical trials for OSA. Most studies were based internationally (59.9%). PIs were predominantly male (72.0%); 72.7% had an MD and 28.6% had a PhD. There were no significant differences in funding source (National Institutes of Health vs. industry, P = .14) or institutional geography (international vs. US, P = .73) between surgical and nonsurgical studies. Surgical trials were significantly more likely to have a male PI and involve pediatric patients compared to nonsurgical trials (P < .001). Otolaryngologists represented 9.2% of all PIs and had similar rates of NIH funding compared to other medical specialists (P = .22).

Conclusions

This study provides a broad overview of past, current, and future treatment paradigms for OSA. Sleep surgery, specifically otolaryngology, is a small voice in the overall landscape of clinical trials for OSA. This information can help guide future research efforts and direct our specialty when setting priorities regarding research funding while encouraging a broad and interdisciplinary pursuit.

Level of Evidence

Laryngoscope, 129:1940–1944, 2019

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Volume129, Issue8

August 2019

Pages 1940-1944

Clinical Trials in Obstructive Sleep Apnea: Recognizing Trends and Future Opportunities

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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Clinical Trials in Obstructive Sleep Apnea: Recognizing Trends and Future Opportunities

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

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