Send correspondence to Yenlin Huang, MD, PhD, Department of Anatomic Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan, No. 5, Fu-Hsing Street, Kwei-Shan, Taoyuan, Taiwan 33305. E-mail: [email protected]Search for more papers by this author

Dante De Paz MD,

Dante De Paz MD

Department of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Department of Head and Neck Surgery , San Pedro University, Chimbote, Peru

d.d. and k.-p.c. contributed equally to this work.

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Kai-Ping Chang MD, PhD,

Kai-Ping Chang MD, PhD

orcid.org/0000-0003-1777-9578

College of Medicine , Chang Gung University, Taoyuan, Taiwan

d.d. and k.-p.c. contributed equally to this work.

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Huang-Kai Kao MD,

Huang-Kai Kao MD

orcid.org/0000-0001-5083-3834

Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

College of Medicine , Chang Gung University, Taoyuan, Taiwan

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William Wei-Kai Lao MD,

William Wei-Kai Lao MD

College of Medicine , Chang Gung University, Taoyuan, Taiwan

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Yu-Chen Huang DDS,

Yu-Chen Huang DDS

Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Yu-Liang Chang DDS, PhD,

Yu-Liang Chang DDS, PhD

Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Yenlin Huang MD, PhD,

Corresponding Author

Yenlin Huang MD, PhD

[email protected]

Department of Anatomic Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

College of Medicine , Chang Gung University, Taoyuan, Taiwan

First published: 10 August 2018

https://doi.org/10.1002/lary.27413

Citations: 17

Editor's Note: This Manuscript was accepted for publication on june 4, 2018

This study was supported by grants from Chang Gung Memorial Hospital, Taiwan (CORPG3G0171 and CIRPG3B0013).

The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives/Hypothesis

The role of tumor-associated tissue eosinophilia (TATE) in oral cavity cancer remains quite controversial. This study investigated the potential role of TATE in tongue squamous cell carcinoma (TSCC).

Study Design

Retrospective case series.

Methods

This study retrospectively enrolled 259 consecutive TSCC patients who underwent surgery between July 2004 and December 2015. Histopathological examinations for TATE in TSCC tumors were reviewed, and the association of TATE with different clinicopathological factors was evaluated. A nomogram was generated based on several major clinicopathological factors and TATE to improve the accuracy of prognostic prediction.

Results

Higher levels of TATE were significantly associated with male sex, alcohol consumption, cigarette smoking, higher pT classification, advanced disease stage, and tumor depth (P = .006, .003, .024, .041, .013 and .006, respectively). Our results indicated that extranodal extension, cell differentiation, and TATE were independent predictors of overall survival (P < .001, .004, and .032, respectively) and disease-free survival (P < .001, .012, and .013, respectively). TATE levels significantly correlated with circulating eosinophils (r = 0.139, P = .040), and the c-index of our nomogram foroverall survival was 0.786, which demonstrates better accuracy in prognosis prediction than the TNM stage only (c-index = 0.738).

Conclusions

Higher levels of TATE were associated with several clinicopathological factors and poorer survival rates, and a nomogram incorporating TATE levels may strengthen the prediction accuracy of prognosis in TSCC patients.

Level of Evidence

4 Laryngoscope, 129:1123–1129, 2019

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Volume129, Issue5

May 2019

Pages 1123-1129

Clinical Implications of Tumor-Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

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BIBLIOGRAPHY

Citing Literature

References

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Clinical Implications of Tumor-Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

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