Facial Plastics and Reconstructive Surgery

Selectin blockade decreases postischemic recruitment of bone marrow stromal cells

Correction(s) for this article

Brian Lawton MD

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

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Jennings R. Boyette MD,

Jennings R. Boyette MD

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

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Melissa Hu MD,

Melissa Hu MD

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

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Timothy S. Lian MD, FACS,

Corresponding Author

Timothy S. Lian MD, FACS

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

Send correspondence to Timothy Lian, MD, Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130-3932. E-mail: [email protected]Search for more papers by this author

Brian Lawton MD,

Brian Lawton MD

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

Search for more papers by this author

Jennings R. Boyette MD,

Jennings R. Boyette MD

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

Search for more papers by this author

Melissa Hu MD,

Melissa Hu MD

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

Search for more papers by this author

Timothy S. Lian MD, FACS,

Corresponding Author

Timothy S. Lian MD, FACS

Department of Otolaryngology–Head and Neck Surgery, Louisiana State University–Shreveport Health Sciences Center, Shreveport, Louisiana, U.S.A.

First published: 27 May 2013

https://doi.org/10.1002/lary.24217

Citations: 1

The authors have no funding, financial relationships, or conflicts of interest to disclose.

Presented at the Triological Society Annual Meeting, Orlando, Florida, U.S.A., April 13, 2013.

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Abstract

Objectives/Hypothesis

Investigate the localization mechanisms of bone marrow stromal cells following transient ischemia-reperfusion injury in a murine flap model.

Study Design

Controlled laboratory study.

Methods

A cutaneous flap based on the inferior epigastric artery was elevated, and transient ischemia of 3.5 hours using a microvascular clamp was achieved. Fucoidan was injected intravenously 24 hours before the ischemic period. Following the period of ischemia, radiolabeled bone marrow stromal cells were injected intravenously, and radioactivity was determined postoperatively.

Results

Attenuation of the uptake of bone marrow stromal cells into postischemic tissue was observed in those mice treated with fucoidan as indicated by gamma counts measured in the flaps when compared with controls (P < . 001).

Conclusions

Decreased uptake of radiolabeled bone marrow stromal cells into postischemic tissues pretreated with fucoidan indicates selectin-mediated bone-marrow stromal cell recruitment in a murine cutaneous flap model.

Level of Evidence

N/A. Laryngoscope, 123:2993–2995, 2013

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Citing Literature

Volume123, Issue12

December 2013

Pages 2993-2995

Selectin blockade decreases postischemic recruitment of bone marrow stromal cells

Correction(s) for this article

Erratum to Selectin blockade decreases postischemic recruitment of bone marrow stromal cells

Abstract

Objectives/Hypothesis

Study Design

Methods

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BIBLIOGRAPHY

Citing Literature

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Selectin blockade decreases postischemic recruitment of bone marrow stromal cells

Correction(s) for this article

Erratum to Selectin blockade decreases postischemic recruitment of bone marrow stromal cells

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

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