Molecular interaction of nonsteroidal anti-inflammatory prodrug nepafenac with ionic surfactants
Arshi Abbas
Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
Search for more papers by this authorCorresponding Author
Syed Salman Shafqat
Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
Correspondence
Syed Salman Shafqat, Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
Email: [email protected]
Muhammad Nadeem Zafar, Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Muhammad Faizan Nazar
Department of Chemistry, University of Education, Lahore, Multan Campus, Multan, Pakistan
Correspondence
Syed Salman Shafqat, Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
Email: [email protected]
Muhammad Nadeem Zafar, Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Email: [email protected] and [email protected]
Search for more papers by this authorHafeez Ullah Khan
Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha, Pakistan
Search for more papers by this authorAsma Mukhtar
School of Chemistry, University of the Punjab, Lahore, Pakistan
Search for more papers by this authorMuhammad Tayyab
Key Laboratory for Advanced Materials, Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai, China
Search for more papers by this authorAsad Syed
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
Search for more papers by this authorCorresponding Author
Muhammad Nadeem Zafar
Department of Chemistry, University of Gujrat, Gujrat, Pakistan
Correspondence
Syed Salman Shafqat, Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
Email: [email protected]
Muhammad Nadeem Zafar, Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Email: [email protected] and [email protected]
Search for more papers by this authorSyeda Amna Masood
Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha, Pakistan
Search for more papers by this authorKashif Kamran
Department of Physics, University of Agriculture, Faisalabad, Pakistan
Search for more papers by this authorArshi Abbas
Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
Search for more papers by this authorCorresponding Author
Syed Salman Shafqat
Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
Correspondence
Syed Salman Shafqat, Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
Email: [email protected]
Muhammad Nadeem Zafar, Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Muhammad Faizan Nazar
Department of Chemistry, University of Education, Lahore, Multan Campus, Multan, Pakistan
Correspondence
Syed Salman Shafqat, Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
Email: [email protected]
Muhammad Nadeem Zafar, Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Email: [email protected] and [email protected]
Search for more papers by this authorHafeez Ullah Khan
Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha, Pakistan
Search for more papers by this authorAsma Mukhtar
School of Chemistry, University of the Punjab, Lahore, Pakistan
Search for more papers by this authorMuhammad Tayyab
Key Laboratory for Advanced Materials, Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai, China
Search for more papers by this authorAsad Syed
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
Search for more papers by this authorCorresponding Author
Muhammad Nadeem Zafar
Department of Chemistry, University of Gujrat, Gujrat, Pakistan
Correspondence
Syed Salman Shafqat, Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
Email: [email protected]
Muhammad Nadeem Zafar, Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan.
Email: [email protected] and [email protected]
Search for more papers by this authorSyeda Amna Masood
Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha, Pakistan
Search for more papers by this authorKashif Kamran
Department of Physics, University of Agriculture, Faisalabad, Pakistan
Search for more papers by this authorAbstract
Drug-surfactant interaction increases the solubility of poorly water-soluble drugs and design better pharmaceutical formulations. The degree of interaction of nepafenac (NP), a nonsteroidal anti-inflammatory prodrug was studied with ionic surfactant molecules such as cationic surfactant cetrytrimethyl ammonium bromide (CTAB) and anionic surfactant sodium dodecyl sulphate (SDS) in an aqueous medium at room temperature. NP made mixed micelles with CTAB and SDS. To investigate the influence of interactions, conductivity measurements, UV–visible spectroscopy, and fluorescence measurements were recorded. The quantification of NP–surfactant interactions was investigated using various mathematical models. The CMC values determined from conductivity measurements of pure surfactants were 0.96 mM for CTAB and 8.14 mM for SDS near to their literature values. At different mole fractions of NP in UV measurements, binding constants from lnKb were found 0.025 and 0.123 and number of NP molecules per micelles (n) 67, 46 for CTAB and SDS, respectively. The mixed micelles of NP–CTAB and NP–SDS revealed that CTAB has a strong interaction with NP than SDS. The Benesi–Hildebrand relationship, Stern–Volmer and Kawamura replica for the partition coefficient were used to confirm the findings. We are confident that the host–guest interaction mechanism can contribute to a better understanding of molecular recognition in the phospholipid membrane model.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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