Abnormal Fetal Findings Associated With a Global Sphericity Index of the 4-Chamber View Below the 5th Centile
Corresponding Author
Greggory R. DeVore MD
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Fetal Diagnostic Centers, Pasadena, Tarzana, and Lancaster, California, USA
Address correspondence to Greggory R. DeVore, MD, Fetal Diagnostic Center, 625 S Fair Oaks Ave, Suite 220, Pasadena, CA 91105 USA. E-mail: [email protected]Search for more papers by this authorGary Satou MD
Division of Pediatric Cardiology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Search for more papers by this authorMark Sklansky MD
Division of Pediatric Cardiology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Search for more papers by this authorCorresponding Author
Greggory R. DeVore MD
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Fetal Diagnostic Centers, Pasadena, Tarzana, and Lancaster, California, USA
Address correspondence to Greggory R. DeVore, MD, Fetal Diagnostic Center, 625 S Fair Oaks Ave, Suite 220, Pasadena, CA 91105 USA. E-mail: [email protected]Search for more papers by this authorGary Satou MD
Division of Pediatric Cardiology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Search for more papers by this authorMark Sklansky MD
Division of Pediatric Cardiology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Search for more papers by this authorAbstract
Objectives
The purpose of this study was to evaluate the global sphericity index (GSI) of the 4-chamber view and correlate the results with abnormal ultrasound findings.
Methods
The epicardial end-diastolic basal-apical length (BAL) and transverse length (TL) of the 4-chamber view were measured to compute the GSI (BAL/TL) in 200 control fetuses between 20 and 40 weeks' gestation. Three hundred study fetuses were prospectively examined between 17 and 39 weeks' gestation. The GSI, Z score, and centile were computed for each of the fetuses.
Results
The GSI (1.233; SD, 0.0953) in the control fetuses was independent of gestational age. Eighteen percent of the study fetuses (55 of 300) had a GSI below the 5th centile (<1.08), of whom 96% (53 of 55) had additional abnormal ultrasound findings. Fetuses with an estimated fetal weight below the 10th centile had a significantly (P < .05) higher rate of an umbilical artery Doppler pulsatility index above the 95th centile (27% versus 17.7%), a middle cerebral artery Doppler pulsatility index below the 5th centile (27% versus 0%), an abnormal cerebroplacental ratio (27% versus 4.5%), and an amniotic fluid index of less than 5 cm (36% versus 9%). The TL was significantly increased compared with the BAL in fetuses with cardiac dysfunction, irrespective of the estimated fetal weight.
Conclusions
An abnormal GSI below the 5th centile is associated with abnormal fetal ultrasound findings.
Supporting Information
Supplemental material online at wileyonlinelibrary.com/journal/jum
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