Volume 127, Issue 5 pp. 882-890
RESEARCH ARTICLE

Non-small cell lung cancer disparities in stage at presentation and treatment for Asian American, Native Hawaiian, and Pacific Islander women

Ji Hyun Hong MD, MPH

Ji Hyun Hong MD, MPH

Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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Nishwant Swami MPH

Nishwant Swami MPH

Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

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Edward Christopher Dee MD

Edward Christopher Dee MD

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Scarlett Lin Gomez PhD

Scarlett Lin Gomez PhD

Department of Epidemiology & Biostatistics and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Miranda B. Lam MD, MBA

Corresponding Author

Miranda B. Lam MD, MBA

Department of Radiation Oncology, Brigham and Women's Hospital/Dana Farber Cancer Institute, Boston, Massachusetts, USA

Harvard Medical School, Boston, Massachusetts, USA

Correspondence Miranda B. Lam, MD MBA, Harvard Medical School, Brigham and Women's Hospital/ Dana Farber Canc Institute, Department of Radiation Oncology, 75 Francis St, Boston, MA 02446, USA.

Email: [email protected]

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First published: 31 January 2023
Citations: 3

Abstract

Background and Objectives

Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPI) represent the fastest-growing group in the United States. While described in aggregate, great variations exist within the community. We aimed to determine whether there were differences in stage at presentation and treatment status among AANHPI women with non-small cell lung cancer (NSCLC).

Methods

Between 2004 and 2016, we identified 522 361 female patients with newly diagnosed NSCLC from the National Cancer Database. Multivariable logistic regression models were used to define adjusted odds ratios (aORs) of presenting with stage IV disease and not receiving treatment.

Results

AANHPI women were more likely to present with stage IV disease compared to White (54.32% vs. 40.28%, p < 0.001). Aside from Hawaiian, Pakistani, and Hmong women, all other ethnic groups had greater odds of presenting with stage IV disease than White women. AANHPI women <65 years were more likely to present with stage IV disease (p = 0.030). Only Vietnamese women showed a significant difference (aOR = 1.30 [1.06–1.58], p = 0.010) for likelihood of receiving treatment compared to White.

Conclusions

Differences in stage at presentation and treatment status in women with NSCLC were observed among AANHPI ethnic groups when populations were disaggregated.

CONFLICT OF INTEREST STATEMENT

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the National Cancer Database Institutional Data Access. Restrictions apply to the availability of these data, which were used under license for this study. Data are available from the author(s) with the permission of the National Cancer Database Institutional Data Access. The authors had full data access and hold final responsibility for manuscript submission.

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