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Analysis of mepivacaine, bupivacaine, etidocaine, lidocaine, and tetracaine
Abstract
A GLC method, employing a nitrogen–phosphorus-sensitive detector, is described for the analysis of mepivacaine, bupivacaine, etidocaine, lidocaine, and tetracaine in biological fluids. The method is simple, reliable, and sensitive, with a practical limit of sensitivity of ∼2.5 ng/ml, well below therapeutic plasma levels. Extensive start-up procedures and sample preparation are not required.
