Research Article
Selection of a reference partitioning system for drug design work
R. Nelson Smith,
Copwin Hansch,
Matthew M. Ames,
Corresponding Author
R. Nelson Smith
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711Search for more papers by this authorCopwin Hansch
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711
Search for more papers by this authorMatthew M. Ames
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711
Search for more papers by this authorR. Nelson Smith,
Copwin Hansch,
Matthew M. Ames,
Corresponding Author
R. Nelson Smith
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711Search for more papers by this authorCopwin Hansch
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711
Search for more papers by this authorMatthew M. Ames
Seaver Chemistry Laboratory, Pomona College, Claremont, CA 91711
Search for more papers by this authorAbstract
Consideration of the structural, polar, and transport properties of water-saturated solvent and solvent-saturated water phases of three general and eight specific binary systems leads to the conclusion that the n-octanol—water system is a very good allround compromise for use as a reference system for biological partitioning in drug design work.
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