Gait characteristics and functional assessment of children with Type I Osteogenesis Imperfecta
Corresponding Author
Adam Graf
Shriners Hospitals for Children, Chicago, Illinois
Shriners Hospitals for Children, Chicago, Illinois. T: 773-385-5458; F: 773-385-5459.Search for more papers by this authorSahar Hassani
Shriners Hospitals for Children, Chicago, Illinois
Search for more papers by this authorJoseph Krzak
Shriners Hospitals for Children, Chicago, Illinois
Search for more papers by this authorAngela Caudill
Orthopaedic & Rehabilitation Engineering Center (OREC), Marquette University/Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorAnn Flanagan
Orthopaedic & Rehabilitation Engineering Center (OREC), Marquette University/Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorRuta Bajorunaite
Department of Mathematics, Statistics and Computer Science, Marquette University, Milwaukee, Wisconsin
Search for more papers by this authorGerald Harris
Shriners Hospitals for Children, Chicago, Illinois
Orthopaedic & Rehabilitation Engineering Center (OREC), Marquette University/Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorCorresponding Author
Adam Graf
Shriners Hospitals for Children, Chicago, Illinois
Shriners Hospitals for Children, Chicago, Illinois. T: 773-385-5458; F: 773-385-5459.Search for more papers by this authorSahar Hassani
Shriners Hospitals for Children, Chicago, Illinois
Search for more papers by this authorJoseph Krzak
Shriners Hospitals for Children, Chicago, Illinois
Search for more papers by this authorAngela Caudill
Orthopaedic & Rehabilitation Engineering Center (OREC), Marquette University/Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorAnn Flanagan
Orthopaedic & Rehabilitation Engineering Center (OREC), Marquette University/Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorRuta Bajorunaite
Department of Mathematics, Statistics and Computer Science, Marquette University, Milwaukee, Wisconsin
Search for more papers by this authorGerald Harris
Shriners Hospitals for Children, Chicago, Illinois
Orthopaedic & Rehabilitation Engineering Center (OREC), Marquette University/Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorAbstract
The purpose of this study was to improve the evaluation process of children with type I Osteogenesis Imperfecta (OI) by providing a quantitative comparison of gait and selected functional assessments to age-matched controls. A 14-camera Vicon Motion Analysis System was used for gait analysis along with selected functional assessments (Pediatric Outcomes Data Collection Instrument [PODCI], Functional Assessment Questionnaire [FAQ], Faces Pain Scale-Revised [FPS-R]) conducted on 10 subjects with type I OI and 22 age-matched healthy controls. The results of the OI group demonstrated abnormal gait parameters including increased double support, delayed foot off, reduced ankle range of motion and plantarflexion during third rocker, along with greater ankle power absorption during terminal stance and reduced ankle power generation during push off. The functional assessment scores of the OI group were similar to the control group for basic mobility and function, but were lower than their peers in the sports and physical function category. The evaluation of individuals with OI by means of gait analysis and selected functional assessments, along with an accurate biomechanical model of the lower extremities, is proposed to better understand and predict OI disability and improve quality of life. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
REFERENCES
- 1 Byers PH, Steiner RD. 1992. Osteogenesis Imperfecta. Annu Rev Med 43: 269–282.
- 2 Chabot G, Zeitlin L. 2004. Current Classification, Clinical Manifestations and Diagnostic Issues of Osteogenesis Imperfecta. In: RM Chiasson, C Munns, L Zeitlin, et al. editors. Interdisciplinary Treatment Approach for Children with Osteogenesis Imperfecta Canada: Shriners Hospitals for Children; p 1–32.
- 3 Long J, Rhode H, Smith P, et al. 2000. Osteogenesis Imperfecta: Physiology, Manifestations, Mobility, and Treatment, In: Pediatric Gait. In: G Harris, P Smith, editors. A New Millennium in Clinical Care and Motion Analysis Technology, 1st edition. New York: IEEE Press; p 124–133.
- 4 Sillence DO, Senn A, Danks DM, et al. 1979. Genetic heterogeneity in osteogenesis imperfecta. J Med Genet 16: 101–116.
- 5 Engelbert RH, Uiterwaal CS, Gulmans VA, et al. 2000. Osteogenesis imperfecta in childhood: prognosis for walking. J Peds Sept. 2000: 397–402.
- 6 Takken T, Terlingen H, Helders P, et al. 2004. Cardiopulmonary fitness and muscle strength in subjects with osteogenesis imperfecta type 1. J Peds Dec. 2004: 813–818.
- 7 Fassier F. 2004. Surgical management of osteogenesis imperfecta. In: RM Chiasson, C Munns, L Zeitlin, et al., editors. Interdisciplinary Treatment Approach for Children with Osteogenesis Imperfecta. Canada: Shriners Hospitals for Children.
- 8 Albright JA. 1981. Systemic treatment of osteogenesis imperfecta. Clin Orthop 159: 88–96.
- 9 Glorieux FH, Bishop NJ, Plotkin H, et al. 1998. Cyclic administration of pamidronate in children with severe osteogenesis imperfecta. N Engl J Med 339: 947–952.
- 10 Rauch F, Travers R, Plotkin H, et al. 2002. The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta. J Clin Invest 110: 1293–1299.
- 11 DiMeglio LA, Peacock M. 2006. Two-year clinical trial of oral alendronate versus intravenous pamidronate in children with osteogenesis imperfecta. J Bone Miner Res 21: 132–140.
- 12 Land C, Rouch F, Montpetit K, et al. 2006. Effect of intravenous pamidronate therapy on functional abilities and level of ambulation in children with osteogenesis imperfecta. J Peds April 2006: 456–460.
- 13 Antoniazzi F, Zamboni G, Lauriola S, et al. 2006. Early bisphosphonate treatment in infants with severe osteogenesis imperfecta. J Peds August 2006: 174–179.
- 14 Engelbert RH, Custers JW, van der Net J, et al. 1997. Functional outcome in osteogenesis imperfecta: disability profiles using the PEDI. Ped PT 9: 18–22.
- 15 Engelbert R, Beemer F, van der Graf Y, et al. 1999. Osteogenesis imperfecta in childhood: Impairment and disability – a follow-up study. Arch Phys Med Rehabil 80: 896–903.
- 16 Engelbert R, Uiterwaal C, Gerver W, et al. 2004. Osteogenesis imperfecta in childhood: impairment and disability. A prospective study with 4-year follow-up. Arch Phys Med Rehabil 85: 772–778.
- 17 Ruck-Gibis J, Plotkin H, Hanley J, et al. 2001. Reliability of the gross motor function measure for children with osteogenesis imperfecta. Ped PT 13: 10–17.
- 18 Widmann R, Laplaza F, Bitan F. 2002. Quality of life in osteogenesis imperfecta. Int Ortho (SCIOT) 26: 3–6.
- 19 Huang RP, Ambrose CG, Sullivan E, et al. 2006. Functional significance of bone density measurements in children with osteogenesis imperfecta. J Bone Joint Sur 88A: 1324–1330.
- 20 Cintas H, Furst G, Lohmann Siegel K, et al. 2003. The brief assessment of motor function (BAMF): reliability and concurrent validity of the gross motor scale. Am J Phys Med Rehabil 82: 33–41.
- 21 Gerber L, Binder H, Weintrob J. 1990. Rehabilitation of children and infants with osteogenesis imperfecta: a program for walking. Clin Ortho Rel Res 251: 254–262.
- 22 Kadaba MP, Ramakrishnan HK, Wooten ME. 1990. Measurement of lower extremity kinematics during level walking. J Res Orthop 8: 383–392.
- 23 Gutierrez EM, Saraste H. 2002. Measuring center of mass displacement during gait: whole-body kinematic model vs. ground reaction force calculation [Abstract]. Conference Proceedings, 4th World Congress of Biomechanics.
- 24 Davis RB, Ounpuu S, Tyburski D, et al. 1991. A gait analysis data collection and reduction technique. Hum Mov Sci 10: 575–587.
- 25 Myers KA, Wang M, Marks RM, et al. 2004. Validation of a multisegment foot and ankle kinematic model for pediatric gait. Neural Systems and Rehabilitation Engineering. IEEE Trans 12: 122–130.
- 26 Kidder SM, Abuzzahab FS, Harris GF, et al. 1996. A system for the analysis of foot and ankle kinematics during gait. Rehabilitation Engineering. IEEE Trans 4: 25–32.
- 27 SMALnet http://www.shrinershq.org/.
- 28 Hislop HJ, Montgomery JD. 1995. Worthingham: Muscle testing: techniques of manual examination, 6th edition. Philadelphia: W.B. Saunders Company.
- 29 Lunsford BR, Perry J. 1995. The standing heel-rise test for ankle plantar flexion: criterion for normal. Phys Ther 75: 694–698.
- 30 Sullivan E, Barnes D, Lindon JL, et al. 2007. Relationships among functional outcome measures used for assessing children with ambulatory CP. Dev Med Child Neurol 49: 338–344.
- 31 Hicks CL, von Baeyer CL, Spafford P, et al. 2001. The Faces Pain Scale—Revised: Toward a common metric in a pediatric pain measurement. Pain 93: 173–183. Scale adapted from: Bieri D, Reeve R, Champion GD, et al. 1990. The Faces Pain Scale for the self-assessment of the severity of pain experienced by children: Development, initial validation and preliminary investigation for ratio scale properties. Pain 41: 139–150.
- 32 Novacheck TF, Stout J, Tervo R. 2000. Reliability and validity of the Gillette Functional Assessment Questionnaire as an outcome measure in children with walking disabilities. J Pediatr Orthop 20: 75–81.
- 33
Abu-Faraj Z,
Harris G,
Smith P.
2007.
Plantar pressure-based quantitative assessment of subtalar arthrodesis in the rehabilitation of the planovalgus foot deformity. In:
G Harris,
P Smith,
R Marks, editors.
Foot and Ankle Motion Analysis Clinical Treatment and Technology.
Boca Raton, FL: CRC Press; p
105–130.
10.1201/9781420005745.ch7 Google Scholar
- 34
Frea A,
Long J,
Khazzam M, et al.
2007.
Hallux Rigidus: A pre- and postoperative analysis of gait. In:
G Harris,
P Smith,
R Marks, editors.
Foot and Ankle Motion Analysis Clinical Treatment and Technology.
Boca Raton, FL: CRC Press; p
215–230.
10.1201/9781420005745.ch13 Google Scholar
- 35 Tachdijan MO. 1990. Flexible pes planovalgus (flatfoot). In: MO Tachdijain, editor. Pediatric Orthopedics, Vol. 4, 2nd edition. Philadelphia: WB Saunders; p 2717–2755.
- 36 Lin CJ, Lai KA, Kuan TS, et al. 2001. Correlating factors and clinical significance of flexible flatfoot in preschool children. J Pediatr Orthop 21: 378–382.
- 37 Agnew PS, Raducanu Y. 2000. Issue An algorithmic approach to evaluation of the flatfoot. Avoidance of pitfalls. Clin Podiatr Med Surg 3: 383–396.
- 38 Coleman S. 1983. Complex Foot Deformities in Children. Philadelphia: Lea and Febiger; p 267–272.
- 39 Ounpuu S, Gage JR, Davis RB. 1991. Three-dimensional lower extremity joint kinetics in normal pediatric gait. J Pediatr Orthop 11: 341–349.
- 40 Gage JR. 2004. The treatment of gait problems in cerebral palsy. London: Mac Keith Press.
- 41 Binder H, Conway A, Gerber L. 1993. Rehabilitation approaches to children with osteogenesis imperfecta: a ten-year experience. Arch Phys Med Rehabil 74: 386–390.
- 42 Engelbert R, Gulmans V, Uiterwaal C, et al. 2001. Osteogenesis imperfecta in childhood: perceived competence in relation to impairment and disability. Arch Phys Med Rehabil 82: 943–948.
- 43 Haynes R, Sullivan E. 2001. The Pediatric Orthopaedic Society of North America's Pediatric Orthopaedic functional health questionnaire: an analysis of normals. J Pediatr Orthop 21: 619–621.