Case Report: Human herpesvirus 6 reactivation associated with colitis in a lung transplant recipient
Corresponding Author
F. Lamoth
Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Infectious Diseases Service and Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 44, 1011 Lausanne, Switzerland.===Search for more papers by this authorP.Y. Jayet
Service of Pneumology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorJ.D. Aubert
Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Service of Pneumology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorS. Rotman
Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorC. Mottet
Service of Gastroenterology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorR. Sahli
Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorI. Lautenschlager
Department of Virology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Transplant Unit Research Laboratory, Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Search for more papers by this authorM. Pascual
Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorP. Meylan
Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorCorresponding Author
F. Lamoth
Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Infectious Diseases Service and Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 44, 1011 Lausanne, Switzerland.===Search for more papers by this authorP.Y. Jayet
Service of Pneumology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorJ.D. Aubert
Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Service of Pneumology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorS. Rotman
Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorC. Mottet
Service of Gastroenterology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorR. Sahli
Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorI. Lautenschlager
Department of Virology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Transplant Unit Research Laboratory, Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Search for more papers by this authorM. Pascual
Transplantation Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorP. Meylan
Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Search for more papers by this authorAbstract
Whereas human herpesvirus 6 (HHV-6) reactivation is frequent in solid organ transplant recipients, symptomatic disease is rare. A case of colitis associated with HHV-6B reactivation was observed in a lung transplant recipient. This case report suggests that symptomatic HHV-6 infection may occur in the absence of detectable viremia. J. Med. Virol. 80:1804–1807, 2008. © 2008 Wiley-Liss, Inc.
REFERENCES
- Amo K, Tanaka-Taya K, Inagi R, Miyagawa H, Miyoshi H, Okusu I, Sashihara J, Hara J, Nakayama M, Yamanishi K, Okada S. 2003. Human herpesvirus 6B infection of the large intestine of patients with diarrhea. Clin Infect Dis 36: 120–123.
- Boutolleau D, Fernandez C, André E, Imbert-Marcille BM, Milpied N, Agut H, Gautheret-Dejean A. 2003. Human herpesvirus (HHV)-6 and HHV-7: Two closely related viruses with different infection profiles in stem cell transplantation recipients. J Infect Dis 187: 179–186.
- Boutolleau D, Duros C, Bonnafous P, Caïola D, Karras A, De Castro N, Ouachée M, Narcy P, Gueudin M, Agut H, Gautheret-Dejean A. 2006. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol 35: 257–263.
- Delbridge MS, Karim MS, Shrestha BM, McKane W. 2006. Colitis in a renal transplant patient with human herpesvirus-6 infection. Transpl Infect Dis 8: 226–228.
-
Griffiths PD,
Ait-Khaled M,
Bearcroft CP,
Clark DA,
Quaglia A,
Davies SE,
Burroughs AK,
Rolles K,
Kidd IM,
Knight SN,
Noibi SM,
Cope AV,
Phillips AN,
Emery VC.
1999.
Human herpesvirus 6 and 7 as potential pathogens after liver transplant: Prospective comparison with the effect of cytomegalovirus.
J Med Virol
59:
496–501.
10.1002/(SICI)1096-9071(199912)59:4<496::AID-JMV12>3.0.CO;2-U CAS PubMed Web of Science® Google Scholar
- Halme L, Arola J, Höckerstedt K, Lautenschlager I. 2008. Human herpesvirus 6 infection of the gastroduodenal mucosa. Clin Infect Dis 46: 434–439.
- Hentrich M, Oruzio D, Jäger G, Schlemmer M, Schleuning M, Schiel X, Hiddemann W, Kolb HJ. 2005. Impact of human herpesvirus-6 after haematopoietic stem cell transplantation. Br J Haematol 128: 66–72.
- Jacobs F, Knoop C, Brancart F, Gilot P, Mélot C, Byl B, Delforge ML, Estenne M, Liesnard C, Brussels Heart and Lung Transplantation Group. 2003. Human herpesvirus-6 infection after lung and heart-lung transplantation: A prospective longitudinal study. Transplantation 75: 1996–2001.
- Lautenschlager I, Höckerstedt K, Linnavuori K, Taskinen E. 1998. Human Herpesvirus-6 infection after liver transplantation. Clin Infect Dis 26: 702–707.
- Lautenschlager I, Linnavuori K, Höckerstedt K. 2000. Human herpesvirus-6 antigenemia after liver transplantation. Transplantation 27: 2561–2566.
- Lehto JT, Halme M, Tukiainen P, Harjula A, Sipponen J, Lautenschlager I. 2007. Human herpesvirus-6 and -7 after lung and heart-lung transplantation. J Heart Lung Transplant 26: 41–47.
- Ljungman P, Singh N. 2006. Human herpesvirus-6 infection in solid organ and stem cell transplant recipients. J Clin Virol 37: S87–S91.
- Muheim C, Vogel G, Seydoux C, Gillet M, Mosimann F, Von Segesser L, Sahli R, Estrade C, van Melle G, Meylan PRA. 2002. Determinants of protracted cytomegalovirus infection in solid-organ transplant patients. Transplantation 74: 226–236.
- Rogers J, Rohal S, Carrigan DR, Kusne S, Knox KK, Gayowski T, Wagener MM, Fung JJ, Singh N. 2000. Human herpesvirus-6 in liver transplant recipients: Role in pathogenesis of fungal infections, neurologic complications, and outcome. Transplantation 69: 2566–2573.
- Ruell J, Barnes C, Mutton K, Foulkes B, Chang J, Cavet J, Guiver M, Menasce L, Dougal M, Chopra R. 2007. Active CMV disease does not always correlate with viral load detection. Bone Marrow Transplant 40: 55–61.
- Storch GA. 2007. Piagnostic virology. In: DM Knipe, PM Howley, DE Griffin, et al., editors. Fields virology, 5th edition, Vol. 1. Philadelphia: Lippincott Williams & Wilkins. pp 565–604.
- Ward KN, Leong HN, Thiruchelvam AD, Atkinson CE, Clark DA. 2007. Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. J Clin Microbiol 45: 1298–1304.
- Yoshikawa T, Ihira M, Suzuki K, Suga S, Iida K, Saito Y, Asonuma K, Tanaka K, Asano Y. 2000. Human herpesvirus 6 infection after living related liver transplantation. J Med Virol 62: 52–59.
Citing Literature
