The seroprevalence rate of human T-lymphotropic virus (HTLV) among the Korean blood donor population was studied to determine whether screening for HTLV should be implemented. A total of 15,173 serum samples collected from June to July 2006 at five Blood Centers which are located closely to Japan geographically, where the prevalence of HTLV is known to be high, were tested. Serological screening was done by a chemiluminescence method. Samples reactive repeatedly on serological screening were confirmed further by Western blot, line immunoassay, nested polymerase chain reaction and sequencing of proviral DNA. Six samples tested reactive with the serological assay showing a reactive rate of 0.004%. Among the six samples, one sample was confirmed as HTLV-1 positive, giving a confirmed reactive rate of 0.007%. Based on the results of this study, an extended study will be conducted to evaluate whether introduction of HTLV screening is necessary in Korea. J. Med. Virol. 80:1864–1867, 2008. © 2008 Wiley-Liss, Inc.

REFERENCES

Couroucé AM, Pillonel J, Lemaire JM, Maniez M, Brunet JB. 1993. Seroepidemiology of HTLV-I/II in universal screening of blood donations in France. AIDS 7: 841–847.
10.1097/00002030-199306000-00013
CAS PubMed Web of Science® Google Scholar
Donegan E, Lee H, Operskalski EA, Shaw GM, Kleinman SH, Busch MP, Stevens CE, Schiff ER, Nowicki MJ, Hollingsworth CG, Mosley JW, the Transfusion Safety Study Group. 1994. Transfusion transmission of retroviruses: Human T-lymphotropic virus types I and II compared with human immunodeficiency virus type 1. Transfusion 34: 478–483.
10.1046/j.1537-2995.1994.34694295061.x
CAS PubMed Web of Science® Google Scholar
Dow BC, Munro H, Ferguson K, Buchanan I, Jarvis L, Jordan T, Franklin IM, McClelland M. 2001. HTLV antibody screening using minipools. Transfus Med 11: 419–422.
10.1046/j.1365-3148.2001.00339.x
CAS PubMed Web of Science® Google Scholar
Kim TY. 2007. The outbreak of transfusion-transmitted HTLV infection by one blood donor with HTLV in Korea. Vox Sang 93: 116.
Google Scholar
Kim JM, Chang KH, Choi YH, Song YG, Kang SM, Yoon TY, Choi JM, Park SY, Lew DJ. 1999. Seroprevalence of HTLV-I in Cheju island, a Korean island adjacent to the endemic area of Japan. J AIDS 22: 409–412.
CAS PubMed Web of Science® Google Scholar
Kleinman S, Swanson P, Allain JP, Lee H. 1993. Transfusion transmission of human T-lymphotropic virus types I and II: Serologic and polymerase chain reaction results in recipients identified through look-back investigations. Transfusion 31: 14–118.
10.1046/j.1537-2995.1993.33193142303.x
Web of Science® Google Scholar
Lu SC, Kao CL, Chin LT, Chen JW, Yang CM, Chang JH, Hsu SC, Chang ACH, Chen BH. 2001. Seroprevalence and demographic characteristics of HTLV-I among blood donors in Taiwan: 1996–1999. Int J Hematol 74: 333–337.
10.1007/BF02982070
CAS PubMed Web of Science® Google Scholar
Manns A, Wilks RJ, Murphy EL, Haynes G, Figueroa JP, Barnett M, Hanchard B, Blattner WA. 1992. A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion. Int J Cancer 51: 886–891.
10.1002/ijc.2910510609
CAS PubMed Web of Science® Google Scholar
Matsumoto C, Mitsunaga S, Oguchi T, Mitomi Y, Shimada T, Ichikawa A, Watanabe J, Nishioka K. 1990. Detection of human T-cell leukemia virus type I (HTLV-I) provirus in an infected cell line and in peripheral mononuclear cells of blood donors by the nested double polymerase chain reaction method: Comparison with HTLV-I antibody tests. J Virol 64: 5290–5294.
10.1128/jvi.64.11.5290-5294.1990
CAS PubMed Web of Science® Google Scholar
Matsuoka M, Watanabe T, Kannagi M, Bangham C, Grassmann R, Marriott SJ, Green P, Jeang KT. 2007. Meeting report on the 13th international conference on human retrovirology: Human T-cell leukemia virus research 30 years after adult T-cell leukemia. Cancer Res 67: 10638–10641.
10.1158/0008-5472.CAN-07-2587
CAS PubMed Google Scholar
Okochi K, Sato H, Hinuma Y. 1984. A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: Seroconversion in recipients. Vox Sang 46: 245–253.
10.1111/j.1423-0410.1984.tb00083.x
CAS PubMed Web of Science® Google Scholar
Pawson R, Mufti GJ, Pagliuca A. 1998. Management of adult T-cell leukaemia/lymphoma. Br J Haematol 100: 453–458.
10.1046/j.1365-2141.1998.00582.x
CAS PubMed Web of Science® Google Scholar
Proietti FA, Carneiro-Proietti ABF, Catalan-Soares BC, Murphy EL. 2005. Global epidemiology of HTLV-I infection and associated diseases. Oncogene 24: 6058–6068.
10.1038/sj.onc.1208968
CAS PubMed Web of Science® Google Scholar
Saito M, Moritoyo T, Park JH, Lee BI, Kim JS, Fujisawa J, Osame M, Yoshida M. 1993. Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP. Yonsei Med J 34: 321–327.
10.3349/ymj.1993.34.4.321
CAS PubMed Google Scholar
Seiki M, Hattori S, Hirayama Y, Yoshida M. 1983. Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci 80: 3618–3622.
10.1073/pnas.80.12.3618
CAS PubMed Google Scholar
Stigum H, Magnus P, Samdal HH, Nord E. 2000. Human T-cell lymphotropic virus testing of blood donors in Norway: A cost-effect model. Int J Epidemiol 29: 1076–1084.
10.1093/ije/29.6.1076
CAS PubMed Web of Science® Google Scholar
Stramer SL, Foster GA, Dodd RY. 2006. Effectiveness of human T-lymphotropic virus (HTLV) recipient tracing (lookback) and the current HTLV-I and -II confirmatory algorithm, 1999 to 2004. Transfusion 46: 703–707.
10.1111/j.1537-2995.2006.00788.x
CAS PubMed Web of Science® Google Scholar
Tynell E, Andersson S, Lithander E, Arneborn M, Blomberg J, Hansson HB, Krook A, Nomberg M, Ramstedt K, Shanwell A, Bjorkman A. 1998. Screening for human T cell leukemia/lymphoma virus among blood donors in Sweden: Cost effectiveness analysis. Br Med J 316: 1417–1422.
10.1136/bmj.316.7142.1417
CAS PubMed Web of Science® Google Scholar
Vandamme AM, Van Laethem K, Liu HF, Van Brussel M, Delaporte E, de Castro Costa CM, Fleischer C, Taylor G, Bertazzoni U, Desmyter J, Goubau P. 1997. Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology. J Med Virol 52: 1–7.
10.1002/(SICI)1096-9071(199705)52:1<1::AID-JMV1>3.0.CO;2-8
CAS PubMed Web of Science® Google Scholar
Vrielink H, Van der Poel CL, Reesink HW. 1995. Efficacy of selected versus random blood donor screening for anti-HTLV-I antibodies. Vox Sang 68: 251–252.
10.1111/j.1423-0410.1995.tb02584.x
CAS PubMed Web of Science® Google Scholar
Yamaguchi K. 1994. HTLV-I in Japan. Lancet 343: 213–215.
10.1016/S0140-6736(94)90994-6
PubMed Web of Science® Google Scholar

Citing Literature

Volume80, Issue10

October 2008

Pages 1864-1867

Seroprevalence of human T-lymphotropic virus type 1 and 2 in Korean blood donors

Abstract

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Seroprevalence of human T-lymphotropic virus type 1 and 2 in Korean blood donors

Abstract

REFERENCES

Citing Literature

References

Related

Information