Association of JC virus with tubulointerstitial nephritis in a renal allograft recipient
Mei-Chin Wen
Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorChia-Liang Wang
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorMeilin Wang
Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan
Search for more papers by this authorChi-Hung Cheng
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorMing-Ju Wu
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorCheng-Hsu Chen
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorCorresponding Author
Kuo-Hsiung Shu
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Department of Medicine, Chung Shan Medical University, Taichung, Taiwan
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 160, Sec 3, Chung-Kang Road, Taichung, Taiwan.===Search for more papers by this authorDeching Chang
Institute of Molecular Biology, National Chung Cheng University, Chia-Yi, Taiwan
Search for more papers by this authorMei-Chin Wen
Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorChia-Liang Wang
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorMeilin Wang
Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan
Search for more papers by this authorChi-Hung Cheng
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorMing-Ju Wu
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorCheng-Hsu Chen
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Search for more papers by this authorCorresponding Author
Kuo-Hsiung Shu
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Department of Medicine, Chung Shan Medical University, Taichung, Taiwan
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 160, Sec 3, Chung-Kang Road, Taichung, Taiwan.===Search for more papers by this authorDeching Chang
Institute of Molecular Biology, National Chung Cheng University, Chia-Yi, Taiwan
Search for more papers by this authorAbstract
A renal allograft transplant patient with tubulointerstitial nephritis was examined for possible involvement of human polyomaviruses. Biopsy of the allograft kidney revealed inflammatory interstitial infiltration with tubulitis and typical inclusion bodies in the nucleus of the tubulo-epithelium. Glomeruli showed duplication and lamination of Bowman's capsule with enlargement of the parietal and visceral epithelia. Immunohistochemical analysis on the graft section using a JC virus (JCV) VP1 peptide-specific antibody showed positive staining. Paracrystalline arrays of naked viral particles with diameters of 40 nm were visualized in the nuclear inclusions under an electron microscope. Molecular examination using the polymerase chain reaction (PCR) and DNA sequencing revealed that the JCV was involved in the nephritis. The results indicated that JCV may be associated with tubulointerstitial nephritis. J. Med. Virol. 72:675–678, 2004. © 2004 Wiley-Liss, Inc.
REFERENCES
- Aoki N, Mori M, Kato K, Sakamoto Y, Noda K, Tajima M, Shimada H. 1996. Antibody against synthetic multiple antigen peptides (MAP) of JC virus capsid protein (VP1) without cross reaction to BK virus: A diagnostic tool for progressive multifocal leukoencephalopathy. Neurosci Lett 205: 111–114.
- Arthur RR, Shah KV, Baust SJ, Santos GW, Saral R. 1986. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med 315: 230–234.
- Bedi A, Miller CB, Hanson JL, Goodman S, Ambinder RF, Charache P, Arthur RR, Jones RJ. 1995. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 13: 1103–1109.
- Binet I, Nickeleit V, Hirsch HH, Prince O, Dalquen P, Gudat F, Mihatsch MJ, Thiel G. 1999. Polyomavirus disease under new immunosuppressive drugs. A cause of renal graft dysfunction and graft loss. Transplantation 67: 918–922.
-
Chang D,
Tsai RT,
Wang ML,
Ou WC.
1996.
Different genotypes of human polyomaviruses found in patients with autoimmune diseases in Taiwan.
J Med Virol
48:
204–209.
10.1002/(SICI)1096-9071(199602)48:2<204::AID-JMV14>3.0.CO;2-E CAS PubMed Web of Science® Google Scholar
- Chen CH, Wen MC, Wang ML, Lian DJ, Wu MJ, Cheng CH, Shu KH, Chang D. 2001. A regulatory region rearranged BKV is associated with tubulointerstitial nephritis in a rejected kidney allograft. J Med Virol 64: 82–88.
- Coleman DV, Gardner SD, Field AM. 1973. Human polyomavirus infection in renal allograft recipients. Br Med J 3: 371–375.
- Coleman DV, Mackenzie EFD, Gardner SD, Poulding JM, Amer B, Russell WJI. 1978. Human polyomavirus (BK) infection and ureteric stenosis in renal allograft recipients. J Clin Pathol 31: 338–347.
- Fishman JA. 2002. BK virus nephropathy—Polyomavirus adding insult to injury. N Engl J Med 347: 527–530.
- Gardner SD, Field AM, Coleman DV, Hulme B. 1971. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1: 1253–1257.
- Hair LS, Nuovo G, Powers JM, Sisti MB, Britton B, Miller JR. 1992. Progressive multifocal leucoenphalopathy in patients with HIV. Hum Pathol 23: 663–667.
- Holt DA, Sinnott JT IV, Oehler RL, Bradley EA. 1992. BK virus. Infect Control Hosp Epidemiol 13: 738–741.
- Kahan AV, Coleman DV, Koss LG. 1980. Activation of human polyomavirus infection-detection by cytologic technics. Am J Clin Pathol 74: 326–332.
- Mathur VS, Olson JL, Darragh TM, Yen TSB. 1997. Polyomavirus induced interstitial nephritis in two renal transplant recipients: Case reports and review of the literature. Am J Kidney Dis 29: 754–758.
- Padgett BL, Walker DL, Zurhein GM, Eckroade RJ. 1971. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1: 1257–1260.
- Pahari A, Rees L. 2003. BK virus-associated renal problems—Clinical implications. Pediatr Nephrol 18: 743–748.
- Pappo O, Demetris AJ, Raikow RB, Randhawa PS. 1996. Human polyoma virus infection of renal allografts: Histopathologic diagnosis, clinical significance, and literature review. Modern Pathol 9: 105–109.
- Purighalla R, Shapiro R, McCauley J, Randhawa P. 1995. BK virus infection in a kidney allograft diagnosed by needle biopsy. Am J Kidney Dis 4: 671–673.
- Randhawa PS, Finkelstein S, Scantlebury V, Shapiro R, Vivas C, Jordan M, Picken MM, Demetris AJ. 1999. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 67: 103–109.
- Randhawa PS, Baksh F, Aoki N, Swalsky PA, Scantlebury V, Shapiro R, Vats A, Vivas C, Jordan M, Finkelstein S. 2001. Polyomavirus type JC infection in native and allograft kidneys. Am J Transplant 1: 270.
- Smith RD, Galla JH, Skahan K, Anderson P, Linnemann CC, Jr. 1998. Tubulointerstitial nephritis due to a mutant polyomavirus BK virus strain, BKV(Cin), causing end-stage renal disease. J Clin Microbiol 36: 1660–1665.
- White FA III, Ishaq M, Stoner GL, Frisque RJ. 1992. JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathy. J Virol 66: 5726–5734.
- Yogo Y, Kitamura T, Sugimoto C, Ueki T, Aso Y, Hara K, Taguchi F. 1990. Isolation of a possible archetypal JC virus DNA sequence from non-immunocompromised individuals. J Virol 64: 3139–3143.
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