Volume 19, Issue 2 pp. 161-166
Article
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Immunogenicity of a single dose of trivalent influenza vaccine including A/Philippines (H3N2): Results of a field trial

Dr. Manfred S. Green

Corresponding Author

Dr. Manfred S. Green

Israel Defence Forces Medical Corps, Ministry of Health Central Virology Laboratory, Chaim Sheba Medical Center, Tel Hashomer, Israel

Military Post 02149, Israel Defence Forces, Israel===Search for more papers by this author
Colin Block

Colin Block

Israel Defence Forces Medical Corps, Ministry of Health Central Virology Laboratory, Chaim Sheba Medical Center, Tel Hashomer, Israel

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Lotte Rannon

Lotte Rannon

WHO National Influenza Center, Ministry of Health Central Virology Laboratory, Chaim Sheba Medical Center, Tel Hashomer, Israel

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First published: June 1986
Citations: 3

Abstract

During 1982, a new A(H3N2) influenza ViNS subtype, A/Philippines/2/82, was identified, and this strain was combined with previous A(HlN1) and B influenza virus strains in the trivalent inactivated vaccine recommended for the 1983-1984 influenza season. Prior to the widescale use of this vaccine in Israel, a group of 106 young male soldiers was vaccinated under controlled conditions. Before vaccination, antibody titers greater than or equal to 1:40 were found in 14.1% against A/Philippines (H3N2), 18.1 % against A/England/333/80 (HlNl), and 13.3 % against B/Singapore/222/79. Two weeks following vaccination, 78.9% of the vaccinees for whom repeated blood samples were available, had antibody titers in this range for A/Philippines (H3N2), 92.9% for A/England (HlNl), and 80.0% for B/Singapore. The vaccine was only mildly reactogenic, and there were no cases of absence from work following vaccination. Thus the antibody response of young subjects to a single dose of a vaccine containing a new A(H3N2) subtype was found to be satisfactory, and the side effects experienced were minimal.

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