Research Article

Free-Breathing Compressed Sensing Cine Cardiac MRI for Assessment of Left Ventricular Strain by Feature Tracking in Children

Ke Xu MD

Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China

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Rong Xu MD,

Rong Xu MD

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Hua-yan Xu MD,

Corresponding Author

Hua-yan Xu MD

[email protected]

Address reprint requests to: Y.-k.G., Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# Section 3, South Renmin Road, Chengdu 610041, China. E-mail: [email protected], or H.-y.X., Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# Section 3, South Renmin Road, Chengdu 610041, China. E-mail: [email protected]

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Lin-jun Xie MS,

Lin-jun Xie MS

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Zhi-gang Yang MD, PhD,

Zhi-gang Yang MD, PhD

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

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Hang Fu MD,

Hang Fu MD

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Wei Bai MD,

Wei Bai MD

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Lu Zhang MD,

Lu Zhang MD

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Xiao-yue Zhou PhD,

Xiao-yue Zhou PhD

Siemens Healthineers Digital Technology (Shanghai) Co., Ltd., Shanghai, China

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Ying-kun Guo MD, PhD,

Corresponding Author

Ying-kun Guo MD, PhD

[email protected]

orcid.org/0000-0001-8437-9887

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Ke Xu MD,

Ke Xu MD

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Rong Xu MD,

Rong Xu MD

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Hua-yan Xu MD,

Corresponding Author

Hua-yan Xu MD

[email protected]

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Lin-jun Xie MS,

Lin-jun Xie MS

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Zhi-gang Yang MD, PhD,

Zhi-gang Yang MD, PhD

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

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Hang Fu MD,

Hang Fu MD

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Wei Bai MD,

Wei Bai MD

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Lu Zhang MD,

Lu Zhang MD

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Xiao-yue Zhou PhD,

Xiao-yue Zhou PhD

Siemens Healthineers Digital Technology (Shanghai) Co., Ltd., Shanghai, China

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Ying-kun Guo MD, PhD,

Corresponding Author

Ying-kun Guo MD, PhD

[email protected]

orcid.org/0000-0001-8437-9887

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First published: 08 September 2023

https://doi.org/10.1002/jmri.29003

Citations: 1

The first two authors contributed equally to this work.

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Abstract

Background

Cardiac MRI feature-tracking (FT) with breath-holding (BH) cine balanced steady state free precession (bSSFP) imaging is well established. It is unclear whether FT-strain measurements can be reliably derived from free-breathing (FB) compressed sensing (CS) bSSFP imaging.

Purpose

To compare left ventricular (LV) strain analysis and image quality of an FB CS bSSFP cine sequence with that of a conventional BH bSSFP sequence in children.

Study Type

Prospective.

Subjects

40 children able to perform BHs (cohort 1 [12.1 ± 2.2 years]) and 17 children unable to perform BHs (cohort 2 [5.2 ± 1.8 years]).

Field Strength/Sequence

3T, bSSFP sequence with and without CS.

Assessment

Acquisition times and image quality were assessed. LV myocardial deformation parameters were compared between BH cine and FB CS cine studies in cohort 1. Strain indices and image quality of FB CS cine studies were also assessed in cohort 2. Intraobserver and interobserver variability of strain parameters was determined.

Statistical Tests

Paired t-test, Wilcoxon signed-rank test, intraclass correlation coefficient (ICC), and Bland–Altman analysis. A P-value <0.05 was considered statistically significant.

Results

In cohort 1, the mean acquisition time of the FB CS cine study was significantly lower than for conventional BH cine study (15.6 s vs. 209.4 s). No significant difference were found in global circumferential strain rate (P = 0.089), global longitudinal strain rate (P = 0.366) and EuroCMR image quality scores (P = 0.128) between BH and FB sequences in cohort 1. The overall image quality score of FB CS cine in cohort 2 was 3.5 ± 0.5 with acquisition time of 14.7 ± 2.1 s. Interobserver and intraobserver variabilities were good to excellent (ICC = 0.810 to 0.943).

Data Conclusion

FB CS cine imaging may be a promising alternative technique for strain assessment in pediatric patients with poor BH ability.

Level of Evidence

Technical Efficacy

Stage 1

Supporting Information

References

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Citing Literature

Volume59, Issue5

May 2024

Pages 1832-1840

Free-Breathing Compressed Sensing Cine Cardiac MRI for Assessment of Left Ventricular Strain by Feature Tracking in Children

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Level of Evidence

Technical Efficacy

Supporting Information

References

Citing Literature

References

Information

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