Research Article

Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC-MRS on 3.0 T Study

Jianfeng Bao PhD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Zongye Li MD,

Zongye Li MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yue Zhang MD,

Yue Zhang MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yuchuan Zhuang PhD,

Yuchuan Zhuang PhD

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, USA

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Ying Li MD,

Ying Li MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Xiao Wang PhD, MD,

Xiao Wang PhD, MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yanan Ren MS,

Yanan Ren MS

orcid.org/0000-0001-6801-2719

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Peipei Wang MS,

Peipei Wang MS

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yong Zhang PhD, MD,

Corresponding Author

Yong Zhang PhD, MD

[email protected]

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

Address reprint requests to: Y.Z., Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China. E-mail: [email protected], or J.C., Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China. E-mail: [email protected]

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Jingliang Cheng PhD, MD,

Corresponding Author

Jingliang Cheng PhD, MD

[email protected]

orcid.org/0000-0002-2867-3237

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Jianfeng Bao PhD,

Jianfeng Bao PhD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Zongye Li MD,

Zongye Li MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yue Zhang MD,

Yue Zhang MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yuchuan Zhuang PhD,

Yuchuan Zhuang PhD

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, USA

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Ying Li MD,

Ying Li MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Xiao Wang PhD, MD,

Xiao Wang PhD, MD

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yanan Ren MS,

Yanan Ren MS

orcid.org/0000-0001-6801-2719

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Peipei Wang MS,

Peipei Wang MS

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Yong Zhang PhD, MD,

Corresponding Author

Yong Zhang PhD, MD

[email protected]

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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Jingliang Cheng PhD, MD,

Corresponding Author

Jingliang Cheng PhD, MD

[email protected]

orcid.org/0000-0002-2867-3237

Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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First published: 12 September 2022

https://doi.org/10.1002/jmri.28383

Citations: 1

Jianfeng Bao and Zongye Li have contributed equally to this work.

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Abstract

Background

Unsaturated fatty acids (UFAs) of bone marrow play a critical role in osteoporosis. However, it is difficult to resolve the UFA, especially in the presence of trabecular bone, using conventional magnetic resonance spectroscopy (MRS) methods.

Purpose

To preliminarily compare the bone marrow fatty acids (FAs) composition in the presence of trabecular bone of postmenopausal osteoporosis (PMOP) and healthy controls (HC).

Study Type

Prospective.

Subjects

Total thirty-six postmenopausal women were recruited with CT-confirmed PMOP (n = 19) and HC (n = 17).

Field Strength/Sequences

A 3 T scanner. Localized 2D intermolecular double-quantum coherence-based MRS (iDQC-MRS).

Assessment

In addition to the conventional water and fat peaks, another four crossing peaks of the FAs were well resolved from the L4 vertebral bone marrow using iDQC-MRS technique: allylic methylene (2.0 ppm), terminal methylene (2.2 ppm), diallylic methylene (2.7 ppm), and olefinic (5.3 ppm). The monounsaturated fatty acids (MOFA) and polyunsaturated fatty acids (PUFAs) were then calculated.

Statistical Tests

Differences between PMOP and HC were investigated using the analysis of a t-test, and the relationships were investigated using regression analysis.

Results

MOFAs and PUFAs fractions were significantly lower in the PMOP group compared to the HC group. In contrast, the saturated FAs fraction is significantly higher in the PMOP group. Additionally, decreased PUFAs, MOFAs were moderately negatively correlated with the volumetric bone mineral density (vBMD) in the PMOP group. Furthermore, increased SFAs in PMOP were strongly associated with vBMD.

Data Conclusion

Using spectra resolution enhanced 2D iDQC-MRS technique, we observed low unsaturated FAs levels in the vertebral bone marrow of the PMOP patients. The reduced unsaturated FAs levels in PMOP may be associated with dysfunction of the balance between osteoblastogenesis and osteoclastogenesis.

Level of Evidence

Technical Efficacy Stage

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Citing Literature

Volume57, Issue5

May 2023

Pages 1423-1430

Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC-MRS on 3.0 T Study

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequences

Assessment

Statistical Tests

Results

Data Conclusion

Level of Evidence

Technical Efficacy Stage

References

Citing Literature

References

Information

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Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC-MRS on 3.0 T Study

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequences

Assessment

Statistical Tests

Results

Data Conclusion

Level of Evidence

Technical Efficacy Stage

References

Citing Literature

References

Related

Information