Original Research

Evaluation of Chronic Pancreatitis With T₁ρ MRI: A Preliminary Study

Shuangshuang Sun MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Shuangshuang Sun and Nan Zhou contributed equally to this manuscript.

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Nan Zhou MD,

Nan Zhou MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Shuangshuang Sun and Nan Zhou contributed equally to this manuscript.

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Yongjing Feng MD,

Yongjing Feng MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Ying Lv MD, PhD,

Ying Lv MD, PhD

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Jian He MD, PhD,

Jian He MD, PhD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Song Liu MD,

Song Liu MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Weibo Chen PhD,

Weibo Chen PhD

Philips Healthcare, Shanghai, China

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Wentao Kong MD, PhD,

Corresponding Author

Wentao Kong MD, PhD

Department of Ultrasound, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Address reprint requests to: Wentao Kong, MD, PhD and Zhengyang Zhou, MD, PhD, No. 321 Zhongshan Road, Nanjing 210008, China. E-mail: [email protected] (Kong), [email protected] (Zhou)

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Zhengyang Zhou MD, PhD,

Corresponding Author

Zhengyang Zhou MD, PhD

[email protected]

orcid.org/0000-0002-9555-4617

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Address reprint requests to: Wentao Kong, MD, PhD and Zhengyang Zhou, MD, PhD, No. 321 Zhongshan Road, Nanjing 210008, China. E-mail: [email protected] (Kong), [email protected] (Zhou)

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Shuangshuang Sun MD,

Shuangshuang Sun MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Shuangshuang Sun and Nan Zhou contributed equally to this manuscript.

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Nan Zhou MD,

Nan Zhou MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Shuangshuang Sun and Nan Zhou contributed equally to this manuscript.

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Yongjing Feng MD,

Yongjing Feng MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Ying Lv MD, PhD,

Ying Lv MD, PhD

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Jian He MD, PhD,

Jian He MD, PhD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Song Liu MD,

Song Liu MD

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

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Weibo Chen PhD,

Weibo Chen PhD

Philips Healthcare, Shanghai, China

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Wentao Kong MD, PhD,

Corresponding Author

Wentao Kong MD, PhD

Department of Ultrasound, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Address reprint requests to: Wentao Kong, MD, PhD and Zhengyang Zhou, MD, PhD, No. 321 Zhongshan Road, Nanjing 210008, China. E-mail: [email protected] (Kong), [email protected] (Zhou)

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Zhengyang Zhou MD, PhD,

Corresponding Author

Zhengyang Zhou MD, PhD

[email protected]

orcid.org/0000-0002-9555-4617

Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China

Address reprint requests to: Wentao Kong, MD, PhD and Zhengyang Zhou, MD, PhD, No. 321 Zhongshan Road, Nanjing 210008, China. E-mail: [email protected] (Kong), [email protected] (Zhou)

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First published: 07 August 2020

https://doi.org/10.1002/jmri.27302

Citations: 2

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Abstract

Background

Chronic pancreatitis (CP) can result in persistent damage to the endocrine and exocrine tissues of the pancreas. There is an unmet need for quantitative methods to evaluate CP noninvasively.

Purpose

To investigate the utility of T₁ρ magnetic resonance imaging (MRI) for the assessment of CP.

Study Type

Prospective.

Population

Twenty patients with CP and 24 healthy volunteers.

Field Strength/Sequence

3T MRI including T₁ρ sequence (spin lock time = 0, 1, 10, 20, 40, 60 msec).

Assessment

Pancreatic T₁ρ values and anterior–posterior (AP) diameters in the head, body, and tail were measured in all participants. Regions of interest with circle (ROI_circle) and free-hand (ROI_FH) were drawn for T₁ρ value measurements.

Statistical Tests

Mann–Whitney U-test; Wilcoxon Signed Ranks test; receiver operating characteristic (ROC) curve; and Bland–Altman analysis.

Results

The T₁ρ values of pancreatic tail and the mean T₁ρ values for ROI_circle and the T₁ρ values of pancreatic tail for ROI_FH in patients with CP were significantly higher than those in healthy volunteers (all P < 0.05). Pancreatic head AP diameter significantly increased, while pancreatic tail AP diameter significantly decreased in patients with CP compared with healthy volunteers (both P < 0.05). The areas under the ROC curves (AUCs) of pancreatic tail T₁ρ values with ROI_circle and tail AP diameter in diagnosing CP were 0.744 and 0.798, respectively. A combination of pancreatic tail T₁ρ values with ROI_circle and tail AP diameter achieved good performance for diagnosing CP (AUC = 0.838).

Data Conclusion

T₁ρ MRI might be a potential technique for the noninvasive evaluation of CP.

Level of Evidence 2

Technical Efficacy Stage 2

J. MAGN. RESON. IMAGING 2021;53:577–584.

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Volume53, Issue2

February 2021

Pages 577-584

Evaluation of Chronic Pancreatitis With T₁ρ MRI: A Preliminary Study

Abstract

Background

Purpose

Study Type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Information

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Evaluation of Chronic Pancreatitis With T1ρ MRI: A Preliminary Study

Abstract

Background

Purpose

Study Type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

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Evaluation of Chronic Pancreatitis With T₁ρ MRI: A Preliminary Study