Review Article
So You Want to Image Myelin Using MRI: An Overview and Practical Guide for Myelin Water Imaging
Jongho Lee PhD,
Jae-Won Hyun MD, PhD,
Jieun Lee BS,
Eun-Jung Choi MS,
Hyeong-Geol Shin MS,
Kyeongseon Min MS,
Yoonho Nam PhD,
Ho Jin Kim MD, PhD,
Se-Hong Oh PhD,
Jongho Lee PhD
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
The first two authors contributed equally to this work.Search for more papers by this authorJae-Won Hyun MD, PhD
Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Korea
The first two authors contributed equally to this work.Search for more papers by this authorJieun Lee BS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorEun-Jung Choi MS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorHyeong-Geol Shin MS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorKyeongseon Min MS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorYoonho Nam PhD
Department of Radiology, Seoul Saint Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
Search for more papers by this authorCorresponding Author
Ho Jin Kim MD, PhD
Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Korea
Address reprint requests to: H.J.K., Department of Neurology, Research Institute and Hospital of National Cancer Center, 323 Ilsan street, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected], or S.-H.O., Division of Biomedical Engineering, Hankuk University of Foreign Studies, Engineering building 408-2, 81 Oedae-ro, Mohyeon-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected]Search for more papers by this authorCorresponding Author
Se-Hong Oh PhD
Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do, Korea
Imaging Institute, Cleveland Clinic, Cleveland, OH, USA
Address reprint requests to: H.J.K., Department of Neurology, Research Institute and Hospital of National Cancer Center, 323 Ilsan street, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected], or S.-H.O., Division of Biomedical Engineering, Hankuk University of Foreign Studies, Engineering building 408-2, 81 Oedae-ro, Mohyeon-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected]Search for more papers by this authorJongho Lee PhD,
Jae-Won Hyun MD, PhD,
Jieun Lee BS,
Eun-Jung Choi MS,
Hyeong-Geol Shin MS,
Kyeongseon Min MS,
Yoonho Nam PhD,
Ho Jin Kim MD, PhD,
Se-Hong Oh PhD,
Jongho Lee PhD
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
The first two authors contributed equally to this work.Search for more papers by this authorJae-Won Hyun MD, PhD
Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Korea
The first two authors contributed equally to this work.Search for more papers by this authorJieun Lee BS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorEun-Jung Choi MS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorHyeong-Geol Shin MS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorKyeongseon Min MS
Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
Search for more papers by this authorYoonho Nam PhD
Department of Radiology, Seoul Saint Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
Search for more papers by this authorCorresponding Author
Ho Jin Kim MD, PhD
Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Korea
Address reprint requests to: H.J.K., Department of Neurology, Research Institute and Hospital of National Cancer Center, 323 Ilsan street, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected], or S.-H.O., Division of Biomedical Engineering, Hankuk University of Foreign Studies, Engineering building 408-2, 81 Oedae-ro, Mohyeon-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected]Search for more papers by this authorCorresponding Author
Se-Hong Oh PhD
Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do, Korea
Imaging Institute, Cleveland Clinic, Cleveland, OH, USA
Address reprint requests to: H.J.K., Department of Neurology, Research Institute and Hospital of National Cancer Center, 323 Ilsan street, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected], or S.-H.O., Division of Biomedical Engineering, Hankuk University of Foreign Studies, Engineering building 408-2, 81 Oedae-ro, Mohyeon-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do, Republic of Korea. E-mail: [email protected]Search for more papers by this authorContract grant support: This research was supported by National Research Foundation of Korea (NRF-2017M3C7A1047864, NRF-2018R1A4A1025891 and NRF-2017R1C1B1008345) and Institute of Engineering Research at Seoul National University.
Abstract
Myelin water imaging (MWI) is an MRI imaging biomarker for myelin. This method can generate an in vivo whole-brain myelin water fraction map in approximately 10 minutes. It has been applied in various applications including neurodegenerative disease, neurodevelopmental, and neuroplasticity studies. In this review we start with a brief introduction of myelin biology and discuss the contributions of myelin in conventional MRI contrasts. Then the MRI properties of myelin water and four different MWI methods, which are categorized as T2-, T2*-, T1-, and steady-state-based MWI, are summarized. After that, we cover more practical issues such as availability, interpretation, and validation of these methods. To illustrate the utility of MWI as a clinical research tool, MWI studies for two diseases, multiple sclerosis and neuromyelitis optica, are introduced. Additional topics about imaging myelin in gray matter and non-MWI methods for myelin imaging are also included. Although technical and physiological limitations exist, MWI is a potent surrogate biomarker of myelin that carries valuable and useful information of myelin.
Evidence Level: 5
Technical Efficacy: 1
J. MAGN. RESON. IMAGING 2021;53:360-373.
Conflict of Interest
Dr. Kim received consultancy/speaker fees from Celltrion, Eisai, HanAll BioPharma, MedImmune, Merck Serono, Novartis, Sanofi Genzyme, and Teva-Handok and serves on a steering committee for MedImmune/VielaBio.
Supporting Information
| Filename | Description |
|---|---|
| jmri27059-sup-0001-supinfo.docxWord 2007 document , 1.4 MB | Appendix S1. Supporting Information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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