Original Research

Myocardial velocity, intra-, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients

Corresponding Author

Haben Berhane MA

[email protected]

orcid.org/0000-0002-1381-7373

Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

*Address reprint requests to: H.B., Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave., Chicago, IL 60611. E-mail: [email protected]Search for more papers by this author

Alexander Ruh PhD,

Alexander Ruh PhD

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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Nazia Husain MBBS, MPH,

Nazia Husain MBBS, MPH

Department of Pediatrics, Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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Joshua D. Robinson MD,

Joshua D. Robinson MD

orcid.org/0000-0002-2129-5501

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Department of Pediatrics, Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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Cynthia K. Rigsby MD,

Cynthia K. Rigsby MD

orcid.org/0000-0003-1224-2333

Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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Michael Markl PhD,

Michael Markl PhD

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, Illinois, USA

Search for more papers by this author

Haben Berhane MA,

Corresponding Author

Haben Berhane MA

[email protected]

orcid.org/0000-0002-1381-7373

Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

*Address reprint requests to: H.B., Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave., Chicago, IL 60611. E-mail: [email protected]Search for more papers by this author

Alexander Ruh PhD,

Alexander Ruh PhD

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Search for more papers by this author

Nazia Husain MBBS, MPH,

Nazia Husain MBBS, MPH

Department of Pediatrics, Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Search for more papers by this author

Joshua D. Robinson MD,

Joshua D. Robinson MD

orcid.org/0000-0002-2129-5501

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Department of Pediatrics, Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Search for more papers by this author

Cynthia K. Rigsby MD,

Cynthia K. Rigsby MD

orcid.org/0000-0003-1224-2333

Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Search for more papers by this author

Michael Markl PhD,

Michael Markl PhD

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, Illinois, USA

Search for more papers by this author

First published: 12 September 2019

https://doi.org/10.1002/jmri.26916

Citations: 6

Contract grant sponsor: National Institute of Heart, Lung and Blood Disorders (NHLBI); Contract grant number: R01 HL 117888.

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Abstract

Background

Endomyocardial biopsy (EMB) is the standard method for detecting allograft rejection in pediatric heart transplants (Htx). As EMB is invasive and carries a risk of complications, there is a need for a noninvasive alternative for allograft monitoring.

Purpose

To quantify left and right ventricular (LV & RV) peak velocities, velocity twist, and intra-/interventricular dyssynchrony using tissue phase mapping (TPM) in pediatric Htx compared with controls, and to explore the relationship between global cardiac function parameters and the number of rejection episodes to these velocities and intra-/interventricular dyssynchrony.

Study Type

Prospective.

Subjects

Twenty Htx patients (age: 16.0 ± 3.1 years, 11 males) and 18 age- and sex-matched controls (age: 15.5 ± 4.3 years, nine males).

Field Strength/Sequence

5T; 2D balanced cine steady-state free-precession (bSSFP), TPM (2D cine phase contrast with three-directional velocity encoding).

Assessment

LV and RV circumferential, radial, and long-axis velocity–time curves, global and segmental peak velocities were measured using TPM. Short-axis bSSFP images were used to measure global LV and RV function parameters.

Statistical Tests

A normality test (Lilliefors test) was performed on all data. For comparisons, a t-test was used for normally distributed data or a Wilcoxon rank-sum test otherwise. Correlations were determined by a Pearson correlation.

Results

Htx patients had significantly reduced LV (P < 0.05–0.001) and RV (P < 0.05–0.001) systolic and diastolic global and segmental long-axis velocities, reduced RV diastolic peak twist (P < 0.01), and presented with higher interventricular dyssynchrony for long-axis and circumferential motions (P < 0.05–0.001). LV diastolic long-axis dyssynchrony (r = 0.48, P = 0.03) and RV diastolic peak twist (r = –0.64, P = 0.004) significantly correlated with the total number of rejection episodes.

Data Conclusion

TPM detected differences in biventricular myocardial velocities in pediatric Htx patients compared with controls and indicated a relationship between Htx myocardial velocities and rejection history.

Level of Evidence: 2

Technical Efficacy Stage: 3

J. Magn. Reson. Imaging 2020;51:1212–1222.

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Citing Literature

Volume51, Issue4

April 2020

Pages 1212-1222

Myocardial velocity, intra-, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Information

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Myocardial velocity, intra-, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Related

Information