Volume 51, Issue 1 pp. 164-174

Original Research

New parameters of ultrafast dynamic contrast-enhanced breast MRI using compressed sensing

Maya Honda MD,

Maya Honda MD

orcid.org/0000-0002-5337-3455

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Masako Kataoka MD, PhD,

Corresponding Author

Masako Kataoka MD, PhD

[email protected]

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Address reprint requests to: M.K., 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan. E-mail: [email protected]Search for more papers by this author

Natsuko Onishi MD, PhD,

Natsuko Onishi MD, PhD

orcid.org/0000-0003-4495-9187

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York, USA

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Mami Iima MD, PhD,

Mami Iima MD, PhD

orcid.org/0000-0002-1991-2494

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Akane Ohashi MD,

Akane Ohashi MD

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Shotaro Kanao MD, PhD,

Shotaro Kanao MD, PhD

Department of Diagnostic Radiology, Kobe City Medical Center General Hospital, Kobe, Japan

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Marcel Dominik Nickel PhD,

Marcel Dominik Nickel PhD

MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany

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Masakazu Toi MD, PhD,

Masakazu Toi MD, PhD

Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Kaori Togashi MD, PhD,

Kaori Togashi MD, PhD

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Maya Honda MD,

Maya Honda MD

orcid.org/0000-0002-5337-3455

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Masako Kataoka MD, PhD,

Corresponding Author

Masako Kataoka MD, PhD

[email protected]

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Address reprint requests to: M.K., 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan. E-mail: [email protected]Search for more papers by this author

Natsuko Onishi MD, PhD,

Natsuko Onishi MD, PhD

orcid.org/0000-0003-4495-9187

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York, USA

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Mami Iima MD, PhD,

Mami Iima MD, PhD

orcid.org/0000-0002-1991-2494

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Akane Ohashi MD,

Akane Ohashi MD

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Shotaro Kanao MD, PhD,

Shotaro Kanao MD, PhD

Department of Diagnostic Radiology, Kobe City Medical Center General Hospital, Kobe, Japan

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Marcel Dominik Nickel PhD,

Marcel Dominik Nickel PhD

MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany

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Masakazu Toi MD, PhD,

Masakazu Toi MD, PhD

Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Kaori Togashi MD, PhD,

Kaori Togashi MD, PhD

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

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First published: 18 June 2019

https://doi.org/10.1002/jmri.26838

Citations: 51

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Abstract

Background

Ultrafast dynamic contrast-enhanced (UF-DCE) breast MRI is considered a promising method of accelerated breast MRI. However, the value of new kinetic parameters derived from UF-DCE need clinical evaluation.

Purpose

To evaluate the diagnostic performance of the maximum slope (MS), time to enhancement (TTE), and time interval between arterial and venous visualization (AVI) derived from UF-DCE MRI using compressed sensing (CS).

Study Type

Retrospective.

Population

Seventy-five patients with histologically proven breast lesions. The total number of analyzed lesions was 90 (61 malignant and 29 benign).

Field Strength/Sequence

3T MRI with UF-DCE MRI based on the 3D gradient-echo volumetric interpolated breath-hold examination (VIBE) sequence using incoherent k-space sampling combined with a CS reconstruction followed by conventional DCE MRI.

Assessment

The diagnostic performance of the MS, TTE, AVI, and conventional kinetic analysis was analyzed and compared with histology.

Statistical Tests

Wilcoxon rank sum test, receiver operating characteristic analysis.

Results

The MS was larger and the TTE and AVI were smaller for malignant lesions compared with benign lesions: MS: 29.3%/s and 18.4%/s (P < 0.001), TTE: 7.0 and 12.0 seconds (P < 0.001), AVI: 2.7 and 4.4 frames (P = 0.006) for malignant and benign lesions. The discriminating power of the MS (area under the curve [AUC], 0.76) was slightly better than that of conventional kinetic analysis (AUC, 0.69) and comparable to that of the TTE and AVI (AUC, 0.78 and 0.76 for TTE and AVI, respectively). Invasive lobular carcinoma had smaller MS (21.8%/s) among malignant lesions (29.3%/s).

Data Conclusion

The MS, TTE, and AVI can be used to evaluate breast lesions with clinical performance equivalent to that of conventional kinetic analysis. These parameters vary among histologies.

Level of Evidence: 3

Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:164–174.

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Citing Literature

Volume51, Issue1

January 2020

Pages 164-174

New parameters of ultrafast dynamic contrast-enhanced breast MRI using compressed sensing

Abstract

Background

Purpose

Study Type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Information

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New parameters of ultrafast dynamic contrast-enhanced breast MRI using compressed sensing

Abstract

Background

Purpose

Study Type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Related

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