Volume 49, Issue 3 pp. 668-677

Original Research

Histogram Analysis of Native T₁ Mapping and Its Relationship to Left Ventricular Late Gadolinium Enhancement, Hypertrophy, and Segmental Myocardial Mechanics in Patients With Hypertrophic Cardiomyopathy

Chong-Wen Wu MD,

Chong-Wen Wu MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

The first two authors contributed equally to this work.

Search for more papers by this author

Rui Wu MD,

Rui Wu MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

The first two authors contributed equally to this work.

Search for more papers by this author

Ruo-Yang Shi MD,

Ruo-Yang Shi MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Dong-Aolei An MD,

Dong-Aolei An MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Bing-Hua Chen MD,

Bing-Hua Chen MD

orcid.org/0000-0002-2718-8416

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Meng Jiang MD, PhD,

Meng Jiang MD, PhD

Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Andrew Bacyinski DPT,

Andrew Bacyinski DPT

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

Ali Rahim MS,

Ali Rahim MS

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

James M. Deen MS,

James M. Deen MS

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

Jiani Hu PhD,

Jiani Hu PhD

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

Tong-Tong Han MS,

Tong-Tong Han MS

Circle Cardiovascular Imaging, Calgary, Alberta, Canada

Search for more papers by this author

Jian-Rong Xu MD, PhD,

Corresponding Author

Jian-Rong Xu MD, PhD

[email protected]

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Address reprint requests to: L.-M.W. or J.-R.X., Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 PuJian Road, Shanghai 200127, P.R. China. E-mail: [email protected] or [email protected]Search for more papers by this author

Lian-Ming Wu MD, PhD,

Corresponding Author

Lian-Ming Wu MD, PhD

[email protected]

orcid.org/0000-0001-7381-5436

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Chong-Wen Wu MD,

Chong-Wen Wu MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

The first two authors contributed equally to this work.

Search for more papers by this author

Rui Wu MD,

Rui Wu MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

The first two authors contributed equally to this work.

Search for more papers by this author

Ruo-Yang Shi MD,

Ruo-Yang Shi MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Dong-Aolei An MD,

Dong-Aolei An MD

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Bing-Hua Chen MD,

Bing-Hua Chen MD

orcid.org/0000-0002-2718-8416

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Meng Jiang MD, PhD,

Meng Jiang MD, PhD

Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Search for more papers by this author

Andrew Bacyinski DPT,

Andrew Bacyinski DPT

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

Ali Rahim MS,

Ali Rahim MS

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

James M. Deen MS,

James M. Deen MS

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

Jiani Hu PhD,

Jiani Hu PhD

Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA

Search for more papers by this author

Tong-Tong Han MS,

Tong-Tong Han MS

Circle Cardiovascular Imaging, Calgary, Alberta, Canada

Search for more papers by this author

Jian-Rong Xu MD, PhD,

Corresponding Author

Jian-Rong Xu MD, PhD

[email protected]

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

Lian-Ming Wu MD, PhD,

Corresponding Author

Lian-Ming Wu MD, PhD

[email protected]

orcid.org/0000-0001-7381-5436

Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

First published: 24 August 2018

https://doi.org/10.1002/jmri.26272

Citations: 7

Share a link

Email
Wechat
Bluesky

Abstract

Background

The use of native T₁ mapping for evaluation of hypertrophic cardiomyopathy (HCM) is being explored, and its combination with histogram analysis may benefit the accuracy of such assessments.

Purpose

To investigate the relationship of segmental left ventricular wall thickness (LVWT), myocardial fibrosis, and strain parameters with segmental histogram parameters of native T₁ mapping in HCM patients.

Study Type

Retrospective.

Subjects

Ninety-three HCM patients without previous cardiovascular diseases were included.

Field Strength/Sequence

3.0T cardiac MR. Steady-state free precession cine imaging, modified Look–Locker inversion recovery, phase-sensitive inversion recovery.

Assessment

Images were assessed by three experienced radiologists.

Statistical Tests

Mann–Whitney U-tests, area under the curve (AUC), Spearman's rank correlation, intraclass correlation coefficient, and Bland–Altman test were used for statistical analysis.

Results

A higher LVWT value correlated with higher means, minimums, 10^th/25^th/50^th/75^th/90^th percentiles, maximums, kurtosis, entropy, and lower SD and energy of T₁ mapping (P < 0.05 for all), with the correlation being stronger for entropy and energy (Spearman's rho = 0.439 and –0.413, respectively) than other parameters. Late gadolinium enhancement positive (LGE+) segments exhibited higher mean, minimum, 10^th/25^th/50^th/75^th/90^th percentiles, maximum, entropy, and lower energy of T₁ times than late gadolinium enhancement negative (LGE–) segments (P < 0.001 for all). Impaired strain function parameters (peak thickening and thickening rate in radial, circumferential, and longitudinal directions) demonstrated a weak correlation with higher entropy (P < 0.001 for all) and lower energy (P < 0.001 for all).

Data Conclusion

Histogram parameters of native T₁ mapping provide more information than mean T₁ times alone. Among these parameters, entropy and energy may correlate better with LVWT, myocardial late gadolinium enhancement, and strain parameters than mean T₁ times in HCM patients.

Level of Evidence: 2

Technical Efficacy Stage: 2

J. Magn. Reson. Imaging 2019;49:668–677.

References

1Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation 1995; 92: 785.
10.1161/01.CIR.92.4.785
CAS PubMed Web of Science® Google Scholar
2Thierfelder L, Watkins H, MacRae C, et al. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere. Cell 1994; 77: 701.
10.1016/0092-8674(94)90054-X
PubMed Web of Science® Google Scholar
3Enriquez AD, Goldman ME. Management of hypertrophic cardiomyopathy. Ann Glob Health 2014; 80: 35–45.
10.1016/j.aogh.2013.12.004
PubMed Web of Science® Google Scholar
4Parekh K, Markl M, Deng J, de Freitas RA, Rigsby CK. T1 mapping in children and young adults with hypertrophic cardiomyopathy. Int J Cardiovasc Imaging 2017; 33: 109–117.
10.1007/s10554-016-0979-9
PubMed Web of Science® Google Scholar
5Wu LM, An DL, Yao QY, et al. Hypertrophic cardiomyopathy and left ventricular hypertrophy in hypertensive heart disease with mildly reduced or preserved ejection fraction: insight from altered mechanics and native T1 mapping. Clin Radiol 2017; 72: 835–843.
10.1016/j.crad.2017.04.019
PubMed Web of Science® Google Scholar
6Iles LM, Ellims AH, Llewellyn H, et al. Histological validation of cardiac magnetic resonance analysis of regional and diffuse interstitial myocardial fibrosis. Eur Heart J Cardiovasc Imaging 2015; 16: 14–22.
10.1093/ehjci/jeu182
PubMed Web of Science® Google Scholar
7Swoboda PP, Mcdiarmid AK, Erhayiem B, et al. Effect of cellular and extracellular pathology assessed by T1 mapping on regional contractile function in hypertrophic cardiomyopathy. J Cardiovasc Magn Reson 2017; 19: 16.
10.1186/s12968-017-0334-x
PubMed Web of Science® Google Scholar
8Suo S, Zhang K, Cao M, et al. Characterization of breast masses as benign or malignant at 3.0T MRI with whole-lesion histogram analysis of the apparent diffusion coefficient. J Magn Reson Imaging 2015; 43: 894–902.
10.1002/jmri.25043
PubMed Web of Science® Google Scholar
9Li A, Xing W, Li H, et al. Subtype differentiation of small (≤ 4 cm) solid renal mass using volumetric histogram analysis of DWI at 3-T MRI. AJR Am J Roentgenol 2018; 29: W1–W10.
10.2214/AJR.17.19278
Web of Science® Google Scholar
10Surov A, Hamerla G, Meyer HJ, et al. Whole lesion histogram analysis of meningiomas derived from ADC values. Correlation with several cellularity parameters, proliferation index KI 67, nucleic content, and membrane permeability. Magn Reson Imaging 2018 [Epub ahead of print].
10.1016/j.mri.2018.05.009
Web of Science® Google Scholar
11Kozumi M, Ota H, Yamamoto T, et al. Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy. Eur Radiol 2018 [Epub ahead of print].
10.1007/s00330-018-5439-6
PubMed Web of Science® Google Scholar
12Elliott PM, Anastasakis A, Borger MA,, et al. ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J 2014; 35: 2733–2779.
10.1093/eurheartj/ehu284
PubMed Web of Science® Google Scholar
13Westfall PH. Kurtosis as peakedness 1905–2014. R.I.P. Am Stat 2014; 68: 191.
10.1080/00031305.2014.917055
PubMed Web of Science® Google Scholar
14Ogawa R, Kido T, Nakamura M, et al. T1 mapping using saturation recovery single-shot acquisition at 3-Tesla magnetic resonance imaging in hypertrophic cardiomyopathy: comparison to late gadolinium enhancement. Jpn J Radiol 2017; 35: 116–125.
10.1007/s11604-017-0611-5
CAS PubMed Web of Science® Google Scholar
15Wu LM, Chen BH, Yao QY, et al. Quantitative diffusion-weighted magnetic resonance imaging in the assessment of myocardial fibrosis in hypertrophic cardiomyopathy compared with T1 mapping. Int J Cardiovasc Imaging 2016; 32: 1–9.
10.1007/s10554-016-0909-x
Web of Science® Google Scholar
16Małek łA, Werys K, Kłopotowski M, et al. Native T1-mapping for non-contrast assessment of myocardial fibrosis in patients with hypertrophic cardiomyopathy — comparison with late enhancement quantification. Magn Reson Imaging 2015; 33: 718–724.
10.1016/j.mri.2015.04.001
PubMed Web of Science® Google Scholar
17Kato S, Nakamori S, Bellm S, et al. Myocardial native T1 time in patients with hypertrophic cardiomyopathy. Am J Cardiol 2016; 118: 1057–1062.
10.1016/j.amjcard.2016.07.010
PubMed Web of Science® Google Scholar
18Wang YJ, Xu XQ, Hu H, et al. Histogram analysis of apparent diffusion coefficient maps for the differentiation between lymphoma and metastatic lymph nodes of squamous cell carcinoma in head and neck region. Acta Radiol 2017; 1: 284185117730688.
Google Scholar
19Hughes SE. The pathology of hypertrophic cardiomyopathy. Histopathology 2004; 44: 412.
10.1111/j.1365-2559.2004.01835.x
CAS PubMed Web of Science® Google Scholar
20Garg P, Saunders LC, Swift AJ, et al. Role of cardiac T1 mapping and extracellular volume in the assessment of myocardial infarction. Anatol J Cardiol 2018; 19: 404.
PubMed Web of Science® Google Scholar
21Amano Y, Yanagisawa F, Kitamura M, Tachi M, Kumita S. Relationship of nonseptal late gadolinium enhancement to ventricular tachyarrhythmia in hypertrophic cardiomyopathy. J Comput Assist Tomogr 2017; 41: 768–771.
10.1097/RCT.0000000000000599
PubMed Web of Science® Google Scholar
22Puntmann VO, Peker E, Chandrashekhar Y, Nagel E. T1 mapping in characterizing myocardial disease: a comprehensive review. Circ Res 2016; 119: 277.
10.1161/CIRCRESAHA.116.307974
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume49, Issue3

March 2019

Pages 668-677

Histogram Analysis of Native T₁ Mapping and Its Relationship to Left Ventricular Late Gadolinium Enhancement, Hypertrophy, and Segmental Myocardial Mechanics in Patients With Hypertrophic Cardiomyopathy

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Histogram Analysis of Native T1 Mapping and Its Relationship to Left Ventricular Late Gadolinium Enhancement, Hypertrophy, and Segmental Myocardial Mechanics in Patients With Hypertrophic Cardiomyopathy

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Related

Information

Histogram Analysis of Native T₁ Mapping and Its Relationship to Left Ventricular Late Gadolinium Enhancement, Hypertrophy, and Segmental Myocardial Mechanics in Patients With Hypertrophic Cardiomyopathy