Original Research

Noncontrast-enhanced time-resolved 4D dynamic intracranial MR angiography at 7T: A feasibility study

Fei Cong BS

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

University of Chinese Academy of Sciences, Beijing, China

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Yan Zhuo MS,

Corresponding Author

Yan Zhuo MS

[email protected]

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Address reprint requests to: Y.Z., State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. E-mail: [email protected] or L.Y., Stevens Neuroimaging and Informatics Institute, Department of Neurology, Keck School of Medicine, University of Southern California, 2025 Zonal Ave., Los Angeles, CA 90033, USA. E-mail: [email protected]Search for more papers by this author

Songlin Yu MD,

Songlin Yu MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Xianchang Zhang BS,

Xianchang Zhang BS

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

University of Chinese Academy of Sciences, Beijing, China

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Xinyuan Miao PhD,

Xinyuan Miao PhD

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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Jing An MS,

Jing An MS

Siemens Shenzhen Magnetic Resonance Ltd., Siemens MRI Center, Shenzhen, Guangdong, China

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Shuo Wang MD,

Shuo Wang MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Yong Cao MD,

Yong Cao MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Yan Zhang MD,

Yan Zhang MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Hee Kwon Song PhD,

Hee Kwon Song PhD

Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA

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Danny JJ Wang PhD,

Danny JJ Wang PhD

Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

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Lirong Yan PhD,

Corresponding Author

Lirong Yan PhD

[email protected]

Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Fei Cong BS,

Fei Cong BS

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

University of Chinese Academy of Sciences, Beijing, China

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Yan Zhuo MS,

Corresponding Author

Yan Zhuo MS

[email protected]

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Songlin Yu MD,

Songlin Yu MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Xianchang Zhang BS,

Xianchang Zhang BS

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

University of Chinese Academy of Sciences, Beijing, China

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Xinyuan Miao PhD,

Xinyuan Miao PhD

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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Jing An MS,

Jing An MS

Siemens Shenzhen Magnetic Resonance Ltd., Siemens MRI Center, Shenzhen, Guangdong, China

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Shuo Wang MD,

Shuo Wang MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Yong Cao MD,

Yong Cao MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Yan Zhang MD,

Yan Zhang MD

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Hee Kwon Song PhD,

Hee Kwon Song PhD

Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA

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Danny JJ Wang PhD,

Danny JJ Wang PhD

Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

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Lirong Yan PhD,

Corresponding Author

Lirong Yan PhD

[email protected]

Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

First published: 12 December 2017

https://doi.org/10.1002/jmri.25923

Citations: 22

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Abstract

Background

Arterial spin labeling (ASL) based-noncontrast-enhanced 4D MR angiography (NCE 4D MRA) shows potential in characterizing cerebrovascular hemodynamics in cerebrovascular disorders. Ultrahigh-field theoretically benefits ASL signal with increased inherent signal-to-noise ratio (SNR) and prolonged blood T₁, which may provide improved delineation of vasculature in 4D MRA.

Purpose

To investigate the feasibility of NCE 4D MRA using 3D Cartesian trajectory and stack-of-stars (SOS) golden angle radial trajectory at 7T.

Study Type

A prospective study.

Subjects

Six normal volunteers and eight patients with arteriovenous malformation (AVM).

Field Strength/Sequence

NCE 4D MRA with Cartesian and radial trajectories were performed at 3T and 7T.

Assessment

Subjective image quality of 4D MRA was evaluated using a 4-point scale by two experienced neuroradiologists. The characterization of AVM components with 4D MRA and DSA was also graded using the Spetzler–Martin grading scale.

Statistical Tests

Cohen's kappa coefficient was calculated to evaluate the agreement between two readers within each 4D MRA technique (Cartesian and Radial). A Wilcoxon signed-rank test was performed to compare the subjective image quality scores of 4D MRA between Cartesian and radial trajectories, and between 7T and 3T, respectively.

Results

Good-to-excellent image quality was achieved in 4D MRA with both Cartesian (3.83 ± 0.41) and radial (3.42 ± 0.49) acquisitions in healthy volunteers at 7T. However, markedly reduced scan time was needed with radial acquisition. 4D MRA at 7T (3.31 ± 0.59) shows better delineation of AVM lesion features, especially the vein drainage, compared with that of 3T (2.83 ± 0.75), although no statistical significance was achieved (P = 0.180).

Data Conclusion

The feasibility of ASL based 4D MRA at 7T with Cartesian and SOS golden angle radial acquisition was demonstrated. The clinical evaluation of 4D MRA in AVMs between 3T and 7T suggested 7T 4D MRA images acquired with radial acquisition demonstrate excellent delineation of AVM features, especially the draining veins.

Level of Evidence: 2

Technical Efficacy Stage 2

J. Magn. Reson. Imaging 2017.

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Volume48, Issue1

July 2018

Pages 111-120

Noncontrast-enhanced time-resolved 4D dynamic intracranial MR angiography at 7T: A feasibility study

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Information

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Noncontrast-enhanced time-resolved 4D dynamic intracranial MR angiography at 7T: A feasibility study

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Related

Information